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Vardenafil
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| Systematic (IUPAC) name | |
| 4-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-phenyl]- 9-methyl-7-propyl- 3,5,6,8-tetrazabicyclo[4. IUPAC Nomenclature is a system of naming Chemical compounds and of describing the science of Chemistry in general 3. 0] nona-3,7,9-trien-2-one |
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| Identifiers | |
| CAS number | |
| ATC code | G04 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C23H32N6O4S |
| Mol. mass | 488. CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs It is controlled by the WHO Collaborating Centre for Drug A section of the Anatomical Therapeutic Chemical Classification System. PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component The DrugBank database available at the University of Alberta is a unique Bioinformatics and Cheminformatics resource that combines detailed drug (i A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Carbon (kɑɹbən is a Chemical element with the symbol C and its Atomic number is 6 Hydrogen (ˈhaɪdrədʒən is the Chemical element with Atomic number 1 Nitrogen (ˈnaɪtɹəʤɪn is a Chemical element that has the symbol N and Atomic number 7 and Atomic weight 14 Oxygen (from the Greek roots ὀξύς (oxys (acid literally "sharp" from the taste of acids and -γενής (-genēs (producer literally begetteris the Sulfur or sulphur (ˈsʌlfɚ see spelling below) is the Chemical element that has the Atomic number 16 The molecular mass (abbreviated m of a substance, more commonly referred to as molecular weight and abbreviated as MW, is the Mass of one 604 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 15% |
| Protein binding | 95% |
| Metabolism | Hepatic (CYP3A4) |
| Half life | 4–5 hours |
| Excretion | Biliary |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status | |
| Routes | Oral |
Vardenafil (INN) is a PDE5 inhibitor used in the treatment of erectile dysfunction. In Pharmacology, bioavailability is used to describe the fraction of an administered Dose of unchanged drug that reaches the Systemic circulation, one of A drug's efficiency may be affected by the degree to which it binds to the proteins within Blood plasma. Drug metabolism is the Metabolism of drugs, their Biochemical modification or degradation usually through specialized enzymatic systems Cytochrome P450 3A4 (abbreviated CYP3A4) ( a member of the Cytochrome P450 mixed-function oxidase system is one of the most important enzymes involved in the metabolism The biological half-life of a substance is the time it takes for a substance (drug radioactive nuclide or other to lose half of its pharmacologic physiologic or radiologic activity Excretion is the process of eliminating waste products of Metabolism and other non-useful materials The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical if it is used as directed by the mother during For a topic outline on this subject see List of basic Australia topics. The United States of America —commonly referred to as the The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction The Standard for the Uniform Scheduling of Drugs and Poisons, abbreviated SUSDP, is a document used in the regulation of drugs and poisons in Australia. For a topic outline on this subject see List of basic Australia topics. A prescription drug is a licensed medicine that is regulated by legislation to require a prescription before it can be obtained The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom, the UK or Britain,is a Sovereign state located A prescription drug is a licensed medicine that is regulated by legislation to require a prescription before it can be obtained The United States of America —commonly referred to as the In Pharmacology and Toxicology, a route An International Nonproprietary Name ( INN; also known as rINN, for recommended International Nonproprietary Name or pINN for proposed A phosphodiesterase type 5 inhibitor, often shortened to PDE5 inhibitor, is a drug used to block the degradative action of Phosphodiesterase type 5 on It can assist men with this disorder in achieving and maintaining an erection during sexual activity. The erection of the Penis, Clitoris or a Nipple is its enlarged and firm state Human sexual behavior or different human sexual practices encompass a wide range of activities such as strategies to find or attract partners ( Mating and display It is commonly marketed under the trade name Levitra (Bayer AG). For other uses see Bayer (disambiguation or Beyer or Buyer. Bayer AG (German ˈbaɪə () is a German
Contents |
History
Vardenafil was co-marketed by Bayer Pharmaceuticals and GSK under the trade name Levitra. For other uses see Bayer (disambiguation or Beyer or Buyer. Bayer AG (German ˈbaɪə () is a German GlaxoSmithKline plc () is a United Kingdom -based pharmaceutical, biological and Healthcare Company. As of 2005, the co-promotion rights of GSK on Levitra have been "transferred back" to Bayer in many markets outside of the United States. Year 2005 ( MMV) was a Common year starting on Saturday (link displays full calendar of the Gregorian calendar. GlaxoSmithKline plc () is a United Kingdom -based pharmaceutical, biological and Healthcare Company. The United States of America —commonly referred to as the In Italy, Bayer markets the product as Levitra and GSK markets the product as Vivanza. Italy (Italia officially the Italian Republic, (Repubblica Italiana is located on the Italian Peninsula in Southern Europe, and on the two largest Due to European Union trade rules, parallel imports may result in the Vivanza branded packs being seen alongside Levitra packs in pharmacies in other EU member states. The European Union ( EU) is a political and economic union of twenty-seven member states, located primarily in A parallel import is a non- Counterfeit product imported from another country without the permission of the Intellectual property owner
Clinical use
Indications and contraindications are as for other PDE5 inhibitors. A phosphodiesterase type 5 inhibitor, often shortened to PDE5 inhibitor, is a drug used to block the degradative action of Phosphodiesterase type 5 on cGMP-specific phosphodiesterase type 5 is an Enzyme ( from the Phosphodiesterase class As a PDE5 inhibitor, vardenafil is closely related in both function and marketing to sildenafil (Viagra) and tadalafil (Cialis). Sildenafil citrate, sold as Viagra, Revatio and under various other trade names is a drug used to treat Erectile dysfunction (male impotence Tadalafil is an orally administered drug for treating impotence ( Erectile dysfunction) that initially was developed by the Biotechnology company ICOS Structurally, the vardenafil molecule differs from sildenafil by only a methyl group and the position of one nitrogen atom in its structure. In Chemistry, a methyl group is a Hydrophobic Alkyl Functional group named after Methane (4 Nitrogen (ˈnaɪtɹəʤɪn is a Chemical element that has the symbol N and Atomic number 7 and Atomic weight 14 It has a relatively short effective time, comparable to sildenafil.
Adverse drug reactions
More common adverse drug reactions (ADRs) are as per other PDE5 inhibitors and are listed on that page. A phosphodiesterase type 5 inhibitor, often shortened to PDE5 inhibitor, is a drug used to block the degradative action of Phosphodiesterase type 5 on
Common vardenafil-specific ADRs include: nausea. Infrequent ADRs include: abdominal pain, back pain, photosensitivity, abnormal vision, eye pain, facial oedema, hypertension, palpitation, tachycardia, arthralgia, myalgia, rash, itch, priapism. Photosensitivity is the amount to which an object reacts upon receiving Photons especially Visible light. Oedema (or Edema in American English formerly known as dropsy or hydropsy, is the increase of Interstitial fluid in any organ &mdash swelling Hypertension, also referred to as high blood pressure, HTN or HPN, is a medical condition in which the Blood pressure is chronically elevated Arthralgia (from Greek arthro-, joint + -algos, pain literally means joint pain; it is a symptom of injury infection illnesses -- in particular Myalgia means " Muscle Pain " and is a symptom of many diseases and disorders Priapism (πριαπισμός is a potentially harmful and painful medical condition in which the erect Penis does not return to its flaccid state despite (Rossi, 2004)
The use of products containing vardenafil has also been associated with serious side-effects which include serious cardiac events such as heart attacks. In rare cases, the use of vardenafil may result in penile tissue damage and permanent loss of potency. Health Canada (2006)
On October 18, 2007, the FDA announced that a warning about possible sudden hearing loss would be added to the drug labels of vardenafil and other PDE5 inhibitors. Events 1009 - The Church of the Holy Sepulchre, a Christian church in Jerusalem, is completely destroyed by the Fatimid Year 2007 ( MMVII) was a Common year starting on Monday of the Gregorian calendar in the 21st century. [1]
Drug interactions
Products containing vardenafil should not be used by individuals who are taking any nitrate medication because combining these products could result in the development of potentially life-threatening low blood pressure.
Dose forms
It is available in 2. 5 mg, 5 mg, 10 mg, and 20 mg doses in round orange tablets. The normal starting dose is 10 mg (roughly equivalent to 50 mg of sildenafil). Sildenafil citrate, sold as Viagra, Revatio and under various other trade names is a drug used to treat Erectile dysfunction (male impotence Vardenafil should be taken 1 to 2 hours prior to sexual activity, with a maximum dose frequency of once per day. In some territories, such as the UK, only certain doses may be available, i. e. 5 mg, 10 mg, and 20 mg.
Market structure
In 2000, Viagra sales acccounted for 92 per cent of the global market for prescribed Erectile Dysfunction pills. (pdf)
See also
- PDE5 inhibitor
- Sildenafil (Viagra)
- Tadalafil (Cialis)
Notes
- ^ FDA Announces Revisions to Labels for Cialis, Levitra and Viagra. A phosphodiesterase type 5 inhibitor, often shortened to PDE5 inhibitor, is a drug used to block the degradative action of Phosphodiesterase type 5 on Sildenafil citrate, sold as Viagra, Revatio and under various other trade names is a drug used to treat Erectile dysfunction (male impotence Tadalafil is an orally administered drug for treating impotence ( Erectile dysfunction) that initially was developed by the Biotechnology company ICOS Food and Drug Administration (2007-10-18). Year 2007 ( MMVII) was a Common year starting on Monday of the Gregorian calendar in the 21st century. Events 1009 - The Church of the Holy Sepulchre, a Christian church in Jerusalem, is completely destroyed by the Fatimid Retrieved on 2007-12-08. Year 2007 ( MMVII) was a Common year starting on Monday of the Gregorian calendar in the 21st century. Events 1609 - Biblioteca Ambrosiana opens its reading room the second public library of Europe.
External links
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