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Tetrachlorodecaoxide
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| Systematic (IUPAC) name | |
| Molecular oxygen tetrachlorite hydrate | |
| Identifiers | |
| CAS number | |
| ATC code | ? |
| PubChem | |
| Chemical data | |
| Formula | H2Cl4O11-4 |
| Mol. mass | 319. IUPAC Nomenclature is a system of naming Chemical compounds and of describing the science of Chemistry in general CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs It is controlled by the WHO Collaborating Centre for Drug PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Hydrogen (ˈhaɪdrədʒən is the Chemical element with Atomic number 1 Chlorine (ˈklɔriːn from the Greek word 'χλωρóς' ( khlôros, meaning 'pale green' is the Chemical element with Atomic number 17 and Oxygen (from the Greek roots ὀξύς (oxys (acid literally "sharp" from the taste of acids and -γενής (-genēs (producer literally begetteris the The molecular mass (abbreviated m of a substance, more commonly referred to as molecular weight and abbreviated as MW, is the Mass of one 82 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | Topical, intravenous |
Tetrachlorodecaoxide (TCDO) is a chlorite containing drug used for the dressing of wounds,immunomodulation and as radiation protective agent. In Pharmacology, bioavailability is used to describe the fraction of an administered Dose of unchanged drug that reaches the Systemic circulation, one of Drug metabolism is the Metabolism of drugs, their Biochemical modification or degradation usually through specialized enzymatic systems The biological half-life of a substance is the time it takes for a substance (drug radioactive nuclide or other to lose half of its pharmacologic physiologic or radiologic activity Excretion is the process of eliminating waste products of Metabolism and other non-useful materials The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical if it is used as directed by the mother during The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction In Pharmacology and Toxicology, a route This discusses some chlorine compounds Chlorite is also a type of mineral see Chlorite group. In Medicine, a wound is a type of Injury in which the Skin is torn cut or punctured (an open wound or where blunt force trauma An immunomodulator is a drug used for its effect on the Immune system. Radiation, as in Physics, is Energy in the form of waves or moving Subatomic particles emitted by an atom or other body as it changes from a higher energy It is the active principle of the drug Oxoferin made by Brookes Pharmaceutical Laboratories (Pakistan) Ltd under license from Oxo Chemie GmbH. In May 2002, Oxo Chemie was acquired by Dimethaid Research Inc. ( now Nuvo Research Inc).
Contents |
Mode of action
Several chlorooxygen compounds, hydrogen peroxide and reducing molecules in the presence of chelated iron (Fenton systems) are oxidants of biological relevance. Hydrogen peroxide (H2O2 is a very pale blue liquid which appears colorless in a dilute solution slightly more Viscous than water Chelation is the binding or complexation of a bi- or multidentate Ligand. Fenton's reagent is a solution of Hydrogen peroxide and an Iron Catalyst that is used to Oxidize Contaminants or Waste waters Hemoglobin of the red cells has such iron and activates TCDO. Hemoglobin ( also spelled haemoglobin and abbreviated Hb or Hgb) is the Iron -containing Oxygen -transport Metalloprotein Red blood cells are the most common type of Blood cell and the Vertebrate body's principal means of delivering Oxygen to the body tissues via the Blood It is available as sterile solution for topical use in 1:55 dilution. Due to its oxidizing properties, TCDO can destroy most pathogens although it is not regarded as antibiotic. A pathogen (from Greek πάθος pathos "suffering passion" and γἰγνομαι (γεν- gignomai (gen- "I give birth to" infectious In modern usage an antibiotic is a Chemotherapeutic agent with activity against Microorganisms such as Bacteria, fungi or Protozoa But the main reason for its use for dressing of wounds is not its bactericidal activity. A bactericide or bacteriocide is a substance that kills bacteria and preferably nothing else This drug is regarded as immunomodulating, that is, it acts by stimulating the immune system of the body. An immunomodulator is a drug used for its effect on the Immune system. Tetrachlorodecaoxide combines with the haem part of hemoglobin, myoglobin and peroxidase, forming a TCDO-haemo complex. A heme ( American English) or haem ( British English) is a Prosthetic group that consists of an Iron atom contained in the center of Hemoglobin ( also spelled haemoglobin and abbreviated Hb or Hgb) is the Iron -containing Oxygen -transport Metalloprotein Myoglobin is a single-chain globular Protein of 153 Amino acids containing a Heme ( Iron -containing Porphyrin) Prosthetic Peroxidases ( EC number 1111x are a large family of Enzymes A majority of peroxidase protein sequences can be found in the PeroxiBase database This in turn activates the macrophages and accelerates the process of phagocytosis which engulfs most of the pathogens and cell debris present on the surface of the wound, thus cleaning the wound surface and helping in the regenerative process. Macrophages ( Greek: "big eaters" from makros "large" + phagein "eat" ( Mø) are cells within the tissues that Phagocytosis is the cellular process of engulfing solid particles by the Cell membrane to form an internal Phagosome, or "food vacuole A pathogen (from Greek πάθος pathos "suffering passion" and γἰγνομαι (γεν- gignomai (gen- "I give birth to" infectious Tetrachlorodecaoxide is also mitogenic and chemotactic. A mitogen is a Chemical substance, usually some form of a Protein, that encourages a cell to commence Cell division, triggering Mitosis. Chemotaxis, a kind of Taxis, is the phenomenon in which bodily cells bacteria, and other single-cell or Multicellular organisms direct their movements The mitogenic impulse gives rise to two factors, MDGF(Macrophage derived growth factor) and WAF (Wound angiogenesis factor). The MDGF deposits fibroblasts and synthesizes collagen fibers which fills the gap in the wounds, the WAF helps in the formation of new capillaries which further enhances the healing process. A fibroblast is a type of cell that synthesizes and maintains the Extracellular matrix of many Animal tissues Collagen is the main Protein of Connective tissue in Animals and the most abundant protein in Mammals making up about 50% of the whole-body protein Healing, assessed physically is the process by which the cells in the Body regenerate and repair to reduce the size of a damaged or necrotic area The chemotactic impulse acts on the myocyte (muscle cell) and causes it to contract, thereby bringing the wound edges closer and reducing the wound surface. A myocyte (also known as a myocardial cell is the type of cell found in heart muscles. Simultaneous influence of all these factors accelerate the wound healing with minimal scarring. [1]
WF 10 [Immunokine, Macrokine] is a 1 : 10 dilution of tetrachlorodecaoxide (TCDO) formulated for intravenous injection. In Pharmacology and Toxicology, a route It was developed by Oxo Chemie in Switzerland as an adjunctive therapy to combination antiretroviral and opportunistic infection prophylaxis regimens in AIDS patients. Switzerland (English pronunciation; Schweiz Swiss German: Schwyz or Schwiiz Suisse Svizzera Svizra officially the Swiss Confederation An opportunistic infection is an infection caused by Pathogens that usually do not cause disease in a healthy Immune system. WF 10 specifically targets macrophages. Macrophages ( Greek: "big eaters" from makros "large" + phagein "eat" ( Mø) are cells within the tissues that WF10 potentially modulates disease-related up-regulation of immune responses both in vitro and in vivo. Thus immune response is influenced in a way that inappropriate inflammatory reactions are downregulated. [2]. WF10 is currently being studied in the US, Europe and Asia for treatment of late-stage HIV disease, as well as recurrent prostate cancer, late post-radiation cystitis, autoimmune disease and chronic active hepatitis C disease. The United States of America —commonly referred to as the Human immunodeficiency virus ( HIV) is a Lentivirus (a member of the Retrovirus family that can lead to acquired immunodeficiency syndrome Autoimmune diseases arise from an overactive Immune response of the body against substances and tissues normally present in the body Hepatitis C is a blood-borne infectious disease that is caused by the Hepatitis C virus ( HCV) affecting the Liver. [3]
Oxo Chemie has worldwide patent rights to WF 10 and Dimethaid Research has an exclusive license for marketing and distribution in Canada. A patent is a set of Exclusive rights granted by a State to an inventor or his assignee for a fixed period of time in exchange for a disclosure of an Country to "Dominion of Canada" or "Canadian Federation" or anything else please read the Talk Page WF 10 is approved for use in Thailand under the name IMMUNOKINE in patients with postradiation chronic inflammatory disease including cystitis, proctitis and mucositis. The Kingdom of Thailand (ˈtaɪlænd ราชอาณาจักรไทย, râːtɕʰa-ʔaːnaːtɕɑ̀k-tʰɑj Cystitis is Inflammation of the Urinary bladder. The condition more often affects women but can affect either sex and all age groups Proctitis is an Inflammation of the Anus and the lining of the Rectum, affecting only the last 6 inches of the rectum Mucositis is the painful Inflammation and Ulceration of the Mucous membranes lining the Digestive tract, usually as an adverse effect of [4]
Tetrachlorodecaoxide produces methaemoglobin even if diluted 500 fold, and leads to additional alterations if added in high concentrations to red cells. Methemoglobin (British English Methaemoglobin (pronounced "MET-hemoglobin" is a form of the Oxygen -carrying Protein Hemoglobin (British English Red blood cells are the most common type of Blood cell and the Vertebrate body's principal means of delivering Oxygen to the body tissues via the Blood [5]
Synonym
Ancloximex, Animexan, Balneozoon, Dermazoon, DesoPur, HydroXan, LegioCid, Oxilium, Oxocebron, Oxoferin, Oxomexan, Oxovasin, Oxovir, Oxoviron, Ryoxon , WF10. [6]
See also
- Immunologic adjuvant
- Wounds
- Dressing (medical)
- Ulcer
- Diabetic foot
- HAART or Highly active antiretroviral therapy
References
- ^ Welcome to | Brookes Pharmaceutical Laboratories (Pakistan) Limited |
- ^ Arzneimittelforschung. In Immunology, an adjuvant is an agent that may stimulate the Immune system and increase the response to a Vaccine, without having any specific Antigenic In Medicine, a wound is a type of Injury in which the Skin is torn cut or punctured (an open wound or where blunt force trauma A dressing is an adjunct used by a person for application to a Wound in order to promote healing and/or prevent further harm Ulcers are healing wounds that develop on the skin mucous membranes or eye Diabetic foot is an umbrella term for foot problems in patients with Diabetes mellitus. 2001;51(7):554-62. Chlorite-hemoprotein interaction as key role for the pharmacological activity of the chlorite-based drug WF10. Schempp H, Reim M, Dornisch K, Elstner EF. Institute of Phytopathology, Technical University Munich, Freising, Germany. h. schempp@flg. tum. de. PMID: 11505786
- ^ McGrath MS, Kahn JO, Herndier BG. Development of WF10, a novel macrophage-regulating agent. Curr Opin Investig Drugs. 2002 Mar;3(3):365-73. PMID: 12054081
- ^ WF 10: Macrokine, TCDO, Tetrachlorodecaoxide. Author: Adis International Limited. Source: Drugs in R&D, Volume 5, Number 4, 2004 , pp. 242–244(3). Publisher: Adis International. PMID: 15230635
- ^ Klin Wochenschr. 1989 Jan 4;67(1):20-5. Oxoferin and sodium chlorite--a comparison. Habermann E, Müller B. Rudolf-Buchheim-Institut für Pharmakologie, Justus-Liebig-Universität, Giessen. PMID: 2921839
- ^ Untersuchungen zur Struktur und Stabilität des Tetrachlordecaoxid-Anions (TCDO)
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