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Terbinafine
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| Systematic (IUPAC) name | |
| (E)-N,6,6-trimethyl-N-(naphthalen- 1-ylmethyl)hept-2-en-4-yn-1-amine | |
| Identifiers | |
| CAS number | |
| ATC code | D01 D01BA02 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C21H25N |
| Mol. mass | 291. IUPAC Nomenclature is a system of naming Chemical compounds and of describing the science of Chemistry in general CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs It is controlled by the WHO Collaborating Centre for Drug A section of the Anatomical Therapeutic Chemical Classification System. A section of the Anatomical Therapeutic Chemical Classification System. PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component The DrugBank database available at the University of Alberta is a unique Bioinformatics and Cheminformatics resource that combines detailed drug (i A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Carbon (kɑɹbən is a Chemical element with the symbol C and its Atomic number is 6 Hydrogen (ˈhaɪdrədʒən is the Chemical element with Atomic number 1 Nitrogen (ˈnaɪtɹəʤɪn is a Chemical element that has the symbol N and Atomic number 7 and Atomic weight 14 The molecular mass (abbreviated m of a substance, more commonly referred to as molecular weight and abbreviated as MW, is the Mass of one 43 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | Readily absorbed |
| Protein binding | >99% |
| Metabolism | Hepatic |
| Half life | 36 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
B |
| Legal status | |
| Routes | Oral, topical |
Terbinafine hydrochloride (Lamisil in Australia, Belgium, Brazil, Canada, France, Germany, Hungary, Romania, United Kingdom, and United States, also sold under the name Terbisil) is a synthetic allylamine antifungal. In Pharmacology, bioavailability is used to describe the fraction of an administered Dose of unchanged drug that reaches the Systemic circulation, one of A drug's efficiency may be affected by the degree to which it binds to the proteins within Blood plasma. Drug metabolism is the Metabolism of drugs, their Biochemical modification or degradation usually through specialized enzymatic systems The liver is a vital organ in the human body and is present in Vertebrates and some other animals The biological half-life of a substance is the time it takes for a substance (drug radioactive nuclide or other to lose half of its pharmacologic physiologic or radiologic activity Excretion is the process of eliminating waste products of Metabolism and other non-useful materials The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical if it is used as directed by the mother during The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction In Pharmacology and Toxicology, a route In Medicine, a topical Medication is applied to body surfaces such as the Skin or Mucous membranes for example the Vagina Allylamine is an Organic compound with the formula C3H5NH2 This colourless liquid is the simplest stable unsaturated Amine An antifungal drug is Medication used to treat fungal Infections such as Athlete's foot, Ringworm, Candidiasis (thrush It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Lipophilicity, fat-liking, refers to the ability of a Chemical compound to dissolve in fats oils lipids and non-polar solvents such as Hexane or A nail is a horn -like structure at the end of an animal's Finger or Toe. As a generic it is sold under the name Zabel in Australia. It is now also available as a generic in the United States.
Contents |
Pharmacology
Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol and dichloromethane, soluble in ethanol, and slightly soluble in water. In chemistry hydrochlorides are salts resulting or regarded as resulting from the reaction of Hydrochloric acid with an organic base (mostly Amines Methanol, also known as methyl alcohol, carbinol, wood alcohol, wood naphtha or wood spirits, is a Chemical compound Dichloromethane ( DCM) or methylene chloride is the Chemical compound with the formula CH2Cl2
Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is part of the fungal cell membrane synthesis pathway. Ergosterol (ergosta-5722-trien-3β-ol a Sterol, is a biological precursor (a Provitamin) to Vitamin D2. Squalene monooxygenase (or squalene epoxidase) is an enzyme which uses NADPH to reduce Squalene to 23-oxidosqualene (squalene epoxide The cell membrane (also called the plasma membrane, plasmalemma, or "phospholipid bilayer" is a Selectively permeable Lipid bilayer
Indications
Terbinafine is mainly effective on the dermatophytes group of fungi. A dermatophyte is a parasitic fungus ( Mycosis) that infects the skin
As a 1% cream or powder it is used for superficial skin infections such as jock itch (Tinea cruris), athlete's foot (Tinea pedis) and other types of ringworm. Tinea cruris, also known as jock itch (American English Dhobi itch or scrot rot (British English is a fungal infection of the Athlete's foot, also called Tinea Pedis, is a Parasitic fungal infection of the epidermis of the human foot Ringworm (also called serpigo) is an infection of the skin characterized by a reddish to brownish raised or bumpy patch of skin that may be lighter in the center
Oral 250mg tablets are often prescribed for the treatment of onychomycosis of the toenail or fingernail due to the dermatophyte Tinea unguium. Onychomycosis means fungal infection of the nail. It is the most common disease of the nails and constitutes about a half of all nail abnormalities A nail is a horn -like structure at the end of an animal's Finger or Toe. Onychomycosis means fungal infection of the nail. It is the most common disease of the nails and constitutes about a half of all nail abnormalities Fungal nail infections are located deep under the nail in the cuticle to which topically applied treatments are unable to penetrate in sufficient amounts. In Biology, the term cuticle or cuticula is given to a variety of tough but flexible non-mineral outer coverings of an organism or part of an organism that The tablets may, rarely, cause hepatotoxicity, so patients are warned of this and may be monitored with liver function tests. Drug metabolism in liver The human body identifies almost all drugs as foreign substances (i Liver function tests (LFTs or LFs which include liver enzymes, are groups of Clinical biochemistry laboratory blood assays designed to give information about the
It has been found that terbinafine hydrochloride may induce or exacerbate Subacute Cutaneous Lupus Erythematosus. Persons with Lupus Erythematosus should first discuss possible risks with their doctor before initiation of therapy. Systemic lupus erythematosus ( SLE or lupus,) is a chronic autoimmune disease that can be fatal though with recent medical advances fatalities are becoming [1]
Specific U. S. issues
Many health insurance companies consider these infections to be a cosmetic problem, and either do not cover the cost of the months-long course of Lamisil, which can run into the thousands of dollars, or recommend use of less expensive alternatives like fluconazole. Fluconazole ( INN) (fluːˈkɒnəzoʊl is a Triazole Antifungal drug used in the treatment and prevention of superficial and systemic fungal infections
FDA approval
The U.S. Food and Drug Administration has approved the first generic versions of prescription Lamisil (terbinafine hydrochloride) tablets. The United States of America —commonly referred to as the The remaining patent or exclusivity for Lamisil expired on June 30, 2007. Events 350 - Roman usurper Nepotianus, of the Constantinian dynasty, is defeated and killed by troops of the Usurper Year 2007 ( MMVII) was a Common year starting on Monday of the Gregorian calendar in the 21st century.
On September 28, 2007, the FDA stated that Lamisil (terbinafine hydrochloride, by Novartis AG) is a new treatment approved for use by children aged 4 up. Events 48 BC - Pompey the Great is assassinated on orders of King Ptolemy of Egypt after landing in Egypt. Year 2007 ( MMVII) was a Common year starting on Monday of the Gregorian calendar in the 21st century. Novartis International AG is a multinational Pharmaceutical company based in Basel Switzerland that manufactures drugs such as Clozapine CHILD syndrome (or congenital hemidysplasia with ichthyosiform erythroderma and limb defects) is a genetic disorder The antifungal granules can be sprinkled on a child's food to treat ringworm of the scalp, Tinea capitis. An antifungal drug is Medication used to treat fungal Infections such as Athlete's foot, Ringworm, Candidiasis (thrush Ringworm (also called serpigo) is an infection of the skin characterized by a reddish to brownish raised or bumpy patch of skin that may be lighter in the center Tinea capitis is a superficial fungal infection ( Dermatophytosis) of the Scalp. [2]
References
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