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Toll-like receptor 5
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| Identifiers | ||
| Symbol(s) | TLR5; FLJ10052; MGC126430; MGC126431; SLEB1; TIL3 | |
| External IDs | OMIM: 603031 HomoloGene: 20698 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 7100 | n/a |
| Ensembl | ENSG00000187554 | n/a |
| Uniprot | O60602 | n/a |
| Refseq | NM_003268 (mRNA) NP_003259 (protein) |
n/a (mRNA) n/a (protein) |
| Location | Chr 1: 221.35 - 221.38 Mb | n/a |
| Pubmed search | [1] | n/a |
Toll-like receptor 5, also known as TLR5, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene product is expressed in myelomonocytic cells, and recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha production. [1]
TLR5 recognizes flagellin. Flagellin is a Protein that arranges itself in a hollow cylinder to form the filament in Bacterial Flagellum. [2] Flagellin is the protein monomer that makes up the filament of bacterial flagella, found on nearly all motile bacteria. Flagellin is a Protein that arranges itself in a hollow cylinder to form the filament in Bacterial Flagellum. There are highly conserved regions in the flagellin protein among all bacteria, facilitating the recognition of flagellin by a germ-line encoded receptor such as TLR5. [3]
References
Further reading
- Hayashi F, et al. (2001). "The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. ". Nature 410 (6832): 1099–1103. PMID 11323673.
- Lien E, Ingalls RR (2002). "Toll-like receptors. ". Crit. Care Med. 30 (1 Suppl): S1–11. PMID 11782555.
External links
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