Swiss-Prot is a manually curated biological database of protein sequences. Biological databases are libraries of life sciences information collected from scientific experiments published literature high throughput experiment technology and computational analyses Proteins are large Organic compounds made of Amino acids arranged in a linear chain and joined together by Peptide bonds between the Carboxyl Swiss-Prot was created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. Amos Bairoch is a Swiss bioinformatician born 22 November 1957. The The European Bioinformatics Institute (EBI is a centre for research and services in Bioinformatics, and is part of European Molecular Biology Laboratory (EMBL [1] Swiss-Prot strives to provide reliable protein sequences associated with a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc. ), a minimal level of redundancy and high level of integration with other databases.
In 2002, the UniProt consortium was created: it is a collaboration between the Swiss Institute of Bioinformatics, the European Bioinfomatics Institute and the Protein Information Resource (PIR), funded by the National Institutes of Health. "NIH" redirects here For other meanings of NIH see NIH (disambiguation. Swiss-Prot and its automatically curated supplement TrEMBL, have joined with the Protein Information Resource protein database to produce the UniProt Knowledgebase, the world's most comprehensive catalogue of information on proteins. TrEMBL, Tr anslated EMBL is a very large protein database in Swiss-Prot format generated by computer translation of the The Protein Information Resource (PIR located at Georgetown University Medical Center (GUMC is an integrated public Bioinformatics resource to support genomic UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL [2] As of 3 April 2007, UniProtKB/Swiss-Prot release 52. Events 1043 - Edward the Confessor is crowned King of England. Year 2007 ( MMVII) was a Common year starting on Monday of the Gregorian calendar in the 21st century. 2 contains 263,525 entries. As of 3 April 2007, the UniProtKB/TrEMBL release 35. Events 1043 - Edward the Confessor is crowned King of England. Year 2007 ( MMVII) was a Common year starting on Monday of the Gregorian calendar in the 21st century. 2 contains 4,232,122 entries.
The UniProt consortium produced 3 database components, each optimised for different uses. The UniProt Knowledgebase (UniProtKB (Swiss-Prot + TrEMBL)), the UniProt Non-redundant Reference (UniRef) databases, which combine closely related sequences into a single record to speed similarity searches and the UniProt Archive (UniParc), which is a comprehensive repository of protein sequences, reflecting the history of all protein sequences. UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL TrEMBL, Tr anslated EMBL is a very large protein database in Swiss-Prot format generated by computer translation of the
References
- ^ Bairoch Amos (2000). "Serendipity in bioinformatics, the tribulations of a Swiss bioinformatician through exciting times!". Bioinformatics 16: 48-64. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10812477. — a historical account by Bairoch.
- ^ Wu, C. H. et al. (January 2006) "The Universal Protein Resource (UniProt): an expanding universe of protein information. ". Nucleic Acids Research, 1;34 (Database issue): D187–91. Nucleic Acids Research or NAR is a Peer reviewed Scientific journal published by Oxford University Press.
- Séverine Altairac, "Naissance d’une banque de données: Interview du prof. Amos Bairoch". Protéines à la Une, August 2006. ISSN 1660-9824.
External links
- Swiss-Prot Protein Database (Swiss Institute of Bioinformatics)
- UniProt (Swiss Institute of Bioinformatics)
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