Sudafed is a brand name and registered trademark for a family of over-the-counter (OTC) decongestants manufactured by Pfizer Inc. for sale in the United States, the United Kingdom, Australia and Canada. A brand is a collection of Images and ideas representing an economic producer more specifically it refers to the descriptive verbal attributes and concrete symbols such as a A trademark or trade mark, represented by the symbols ™ and ®, or mark is a distinctive sign or indicator used by an individual Over-the-counter (OTC drugs are medicines that may be sold without a prescription, in contrast to Prescription drugs The name "over-the-counter" A decongestant is a broad class of Medications used to relieve Nasal congestion. Pfizer Incorporated ( is a major Pharmaceutical company, which ranks number one in the world in sales The United States of America —commonly referred to as the The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom, the UK or Britain,is a Sovereign state located For a topic outline on this subject see List of basic Australia topics. Country to "Dominion of Canada" or "Canadian Federation" or anything else please read the Talk Page The name is a reference to the active ingredient, pseudoephedrine hydrochloride, traditionally associated with the product. An active ingredient ( AI) also active pharmaceutical ingredient ( API) or bulk active, is the substance in a drug that is Pharmaceutically Pseudoephedrine (commonly abbreviated as PSE is a sympathomimetic Amine commonly used as a Decongestant. In chemistry hydrochlorides are salts resulting or regarded as resulting from the reaction of Hydrochloric acid with an organic base (mostly Amines However, because of legal restrictions on the sale of pseudoephedrine recently imposed in many markets, some products sold under the Sudafed brand name do not contain any form of pseudoephedrine. Pseudoephedrine (commonly abbreviated as PSE is a sympathomimetic Amine commonly used as a Decongestant.
Switch to phenylephrine
In late 2004, Pfizer started publicly disclosing its plans to make available a new OTC product, Sudafed PE, which does not include pseudoephedrine. "MMIV" redirects here For the Modest Mouse album see " Baron von Bullshit Rides Again " Pseudoephedrine (commonly abbreviated as PSE is a sympathomimetic Amine commonly used as a Decongestant. Sudafed PE contains a different decongestant called phenylephrine, in a formulation sold for years. Phenylephrine or Neo-Synephrine is an α1-adrenergic receptor Agonist used primarily as a Decongestant, as an agent to dilate the Decongestants with other ingredients were completely converted to phenylephrine later in 2005, though original Sudafed is still offered. Year 2005 ( MMV) was a Common year starting on Saturday (link displays full calendar of the Gregorian calendar.
The new product was prompted by existing and proposed restrictions on the availability of pseudoephedrine-based products. State laws imposing such restrictions were in response to pseudoephedrine's role as an ingredient used to produce the illegal and highly addictive stimulant methamphetamine, also known as crystal meth. Drug addiction is widely considered a pathological state. The disorder of addiction involves the progression of acute Drug use to the development of drug-seeking Stimulant drugs are Drugs that temporarily increase alertness and awareness
Pfizer and its predecessor Warner-Lambert had studied at least two alternatives to its current formula in anticipation of pressure from state regulators and the Food and Drug Administration:
- In 1996, the company began testing a patented decongestant ingredient known as "minus" pseudoephedrine. Pfizer Incorporated ( is a major Pharmaceutical company, which ranks number one in the world in sales Year 1996 ( MCMXCVI) was a Leap year starting on Monday (link will display full 1996 Gregorian calendar) The company claimed animal tests showed this altered version offered sinus relief comparable to the current "plus" pseudoephedrine. The difference was that it couldn't be converted to methamphetamine, an illegal drug used recreationally. Pfizer did not bring the new ingredient to market because of the cost and time involved in gaining regulatory approval.
- Pfizer spent $12 million trying to develop additives for Sudafed that might make it harder to remove the pseudoephedrine it contains. They abandoned the project in 2003, seven years after announcing its existence. Year 2003 ( MMIII) was a Common year starting on Wednesday of the Gregorian calendar.
According to L. Hendeles of the University of Florida, "Phenylpropanolamine, pseudoephedrine, and phenylephrine are the most common decongestants. Phenylpropanolamine (PPA is a drug ingredient of the Phenethylamine family used as a Decongestant in prescription and nonprescription (over the counter Although all are sympathomimetic amines, their efficacy varies. Sympathomimetic drugs are substances that mimic the effects of the Catecholamines Epinephrine (adrenaline Norepinephrine (noradrenaline and/or In particular, phenylephrine is subject to first-pass metabolism and therefore is not bioavailable in currently recommended doses. The first-pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of Drug metabolism whereby the Concentration In Pharmacology, bioavailability is used to describe the fraction of an administered Dose of unchanged drug that reaches the Systemic circulation, one of "[1], although 20mg doses do appear to be safe, and anecdotal evidence suggests greater decongestant action at this dose.
In Australia, Sudafed with up to 60mg of pseudoephedrine is available by prescription or subject to a pharmacist matching the purchaser's driver's license to a database and determining if the purchase history is consistent with personal use. If a driver's license is not provided, the pharmacist can, at his or her discretion, still provide the medication.
References
- ^ Hendeles L. (1993 Nov-Dec). "Selecting a decongestant". Pharmacotherapy 13: 129S–134S. Medication, also referred to as medicine, can be loosely defined as any substance intended for use in the diagnosis cure mitigation treatment or prevention of disease PMID 7507590.
External links
- http://www.sudafed.com/
- Sudafed Nasal Decongestant, a summary from the manufacturer
- Was the West's methamphetamine epidemic allowed to happen?, a five-part series published in The Oregonian in October 2004
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