"All-nighter" redirects here. For other uses, see The Allnighter.

Sleep deprivation is a general lack of the necessary amount of sleep. Sleep is a Natural state of bodily rest observed throughout the animal kingdom This may occur as a result of sleep disorders, active choice or deliberate inducement such as in interrogation or for torture. A sleep disorder (somnipathy is a medical disorder of the Sleep patterns of a person or animal Interrogation or questioning is Interviewing as commonly employed by officers of the Police and Military. Torture, according to the United Nations Convention Against Torture, is "any act by which severe pain or suffering, whether physical or mental is intentionally ^[1]

Contents 1 Physiological effects 1.1 Diabetes 1.2 Effects on the brain 1.3 Effects on growth 1.4 Effects on the healing process 1.5 Impairment of ability 1.6 Obesity 2 Uses 2.1 Scientific study 2.2 Torture 2.3 Treatment for depression 2.4 Voluntary 3 Causes and treatments 3.1 School 3.2 Prevention of effects in soldiers 4 See also 5 References 6 External links

Physiological effects

Generally, lack of sleep may result in^{[2][3][4][5][6][7][8][9]}:

Diabetes

A 1996 study by the University of Chicago Medical Center showed that sleep deprivation severely affects the human body's ability to metabolize glucose, which can lead to early-stage Diabetes Type 2. In Psychology, visual perception is the ability to interpret information from Visible light reaching the Eyes The resulting Perception is also Major depressive disorder, also known as major depression, unipolar depression, unipolar disorder, clinical depression, or simply depression Color blindness, a Color vision deficiency is the inability to perceive differences between some of the Colors that others can distinguish Excessive daytime sleepiness (EDS is characterized by persistent sleepiness and often a general lack of energy even after adequate night time sleep In Chemistry, concentration is the measure of how much of a given substance there is mixed with another substance Depersonalization (or depersonalisation) is an 'alteration' in the perception or experience of the self so that one feels 'detached' from and as if one is an 'outside' observer Derealization ( DR) is an alteration in the perception or experience of the external world so that it seems strange or unreal An immune system is a collection of mechanisms within an Organism that protects against Disease by identifying and killing Pathogens and Tumor Many different terms are often used to describe what is collectively known as dizziness. Dark circles or Eye circles are dark blemishes around the Eyes Also known as "bags under the eyes" there are many etiologies to cause this symptom Eyes are organs that detect Light, and send signals along the Optic nerve to the visual areas of the brain Confusion, of a Pathological degree usually refers to loss of orientation (ability to place oneself correctly in the world by time location and personal identity and A hallucination, in the broadest sense is a Perception in the absence of a stimulus. Tremor is an unintentional somewhat rhythmic muscle movement involving to-and-from movements (oscillations of one or more parts of the body A headache ( cephalalgia in medical terminology is a condition of pain in the Head; sometimes Neck or upper back pain may also be interpreted Hyperactivity can be described as a physical state in which a person is abnormally and easily excitable or exuberant Hypertension, also referred to as high blood pressure, HTN or HPN, is a medical condition in which the Blood pressure is chronically elevated Patience (ˈpā-shənz is the state of endurance under difficult circumstances Irritability is an excessive response to stimuli. Irritability takes many forms from the Contraction of a Unicellular organism when touched to complex In Psychology, memory is an organism's ability to store retain and subsequently retrieve information Nausea ( Latin: Nausea, Greek:, " Sea-sickness " also called wamble) is the sensation of unease and discomfort Nystagmus is a type of eye movement characterized by alternating slow phase movements in one direction and Saccade -like quick phases in the other direction Psychosis (from the Greek ψυχή "psyche" for mind or soul and -οσις "-osis" for abnormal condition with adjective psychotic Pallor (also called pastiness or wanness) is a reduced amount of oxy Hemoglobin in Skin or Mucous membrane, a pale color which can In Linguistics ( Articulatory phonetics) manner of articulation describes how the tongue lips and other speech organs are involved in making a sound make Weight loss, in the context of Medicine or Health or Physical fitness, is a reduction of the total Body weight, due to a mean loss of fluid Weight gain is an increase in Body weight. This can be either an increase in Muscle mass, fat deposits or excess fluids such as Water. A yawn (from the Middle English yanen, an alteration of yonen or yenen, which in turn comes from the Old English geonian Attention-Deficit Hyperactivity Disorder (ADHD is a neurobehavioral developmental disorder affecting about 3-5% of the world's population Drunkenness or inebriation is the state of being intoxicated by consumption of Alcoholic beverages to a degree that mental and physical faculties are noticeably The University of Chicago is a Private university located principally in the Hyde Park neighborhood of Chicago. Glucose (Glc a Monosaccharide (or simple Sugar) also known as grape sugar, is an important Carbohydrate in Biology. Diabetes mellitus (ˌdaɪəˈbiːtiːz or /ˌdaɪəˈbiːtəs/ /məˈlaɪtəs/ or /ˈmɛlətəs/ often referred to simply as diabetes ( Ancient Greek: grc ^[10]

Effects on the brain

Sleep deprivation can adversely affect brain function. ^[9] A 2000 study, by the UCSD School of Medicine and the Veterans Affairs Healthcare System in San Diego, used functional magnetic resonance imaging technology to monitor activity in the brains of sleep-deprived subjects performing simple verbal learning tasks. The University of California San Diego (popularly known as UC San Diego or UCSD) is a public Research university in San Diego, California Functional MRI or functional Magnetic Resonance Imaging (fMRI is a type of specialized MRI scan ^[11] The study showed that regions of the brain's prefrontal cortex displayed more activity in sleepier subjects. Depending on the task at hand, the brain would sometimes attempt to compensate for the adverse effects caused by lack of sleep. The temporal lobe, which is a brain region involved in language processing, was activated during verbal learning in rested subjects but not in sleep deprived subjects. The temporal lobes are parts of the cerebrum that are involved in speech, Memory, and Hearing. The parietal lobe, not activated in rested subjects during the verbal exercise, was more active when the subjects were deprived of sleep. The parietal lobe is a lobe in the Brain. It is positioned above (superior to the Occipital lobe and behind (posterior to the Frontal lobe. Although memory performance was less efficient with sleep deprivation, greater activity in the parietal region was associated with better memory.

A 2001 study at Chicago Medical Institute suggested that sleep deprivation may be linked to more serious diseases, such as heart disease and mental illnesses, such as psychosis and bipolar disorder. A 2003 Universtity of California study found that REM sleep deprivation alleviates clinical depression. Major depressive disorder, also known as major depression, unipolar depression, unipolar disorder, clinical depression, or simply depression Although the mechanism is unclear it is suggested that the deprivation mimics the effects of selective serotonin reuptake inhibitors (SSRI) however the study also indicated that REM sleep was essential for blocking neurotransmitters and allowing the neurotransmitter receptors to "rest" and regain sensitivity which in turn leads to improved regulation of mood and increased learning ability. Selective serotonin reuptake inhibitors ( SSRIs) are a class of Antidepressants used in the treatment of depression, Anxiety disorders See Chemical synapse for an introduction to concepts and terminology used in this article Non REM sleep may allow enzymes to repair brain cell damage caused by free radicals. In Chemistry, radicals (often referred to as free radicals) are atoms molecules or ions with Unpaired electrons on an otherwise Open shell High metabolic activity while awake damages the enzymes themselves preventing efficient repair. The study observed the first evidence of brain damage in Rats as a direct result of sleep deprivation. ^[12]

Animal studies suggest that sleep deprivation increases stress hormones, which may reduce new cell production in adult brains. ^[13]

Effects on growth

A 1999 study^[14] found that sleep deprivation resulted in reduced cortisol secretion the next day, driven by increased subsequent slow-wave sleep. Year 1999 ( MCMXCIX) was a Common year starting on Friday (link will display full 1999 Gregorian calendar) Sleep deprivation was found to enhance activity on the Hypothalamic-pituitary-adrenal axis (which controls reactions to stress and regulates body functions such as digestion, the immune system, mood, sex, or energy usage) while suppressing growth hormones. The results supported previous studies, which observed adrenal insufficiency in idiopathic hypersomnia.

Effects on the healing process

A study conducted in 2005 showed that a group of rats who were deprived of five days of sleep had no significant effect on their ability to heal wounds, compared to a group of rats not deprived of sleep. ^[15]

Impairment of ability

According to a 2000 study published in the British Medical Journal, researchers in Australia and New Zealand reported that sleep deprivation can have some of the same hazardous effects as being drunk. ^[16] People who drove after being awake for 17–19 hours performed worse than those with a blood alcohol level of . 05 percent, which is the legal limit for drunk driving in most western European countries (the U. S. and UK set their blood alcohol limits at . Blood alcohol content or blood alcohol concentration (abbreviated BAC) is the concentration of alcohol in a person's Blood. 08 percent). In addition, as a result of continuous muscular activity without proper rest time, effects such as cramping are much more frequent in sleep-deprived individuals. Extreme cases of sleep deprivation have been reported to be associated with hernias, muscle fascia tears, and other such problems commonly associated with physical overexertion. Beyond impaired motor skills, people who get too little sleep may have higher levels of stress, anxiety and depression, and may take unnecessary risks. According to the National Highway Traffic Safety Administration, over 100,000 traffic accidents each year in the USA alone are caused by fatigue and drowsiness. ^[17][18] A new study has shown that while total sleep deprivation for one night caused many errors, the errors were not significant until after the second night of total sleep deprivation. ^[19]

The response latency seem to be higher when it comes to actions regarding personal morality rather than in situations when morality is not in question. The willingness to violate a personal belief has been shown to be moderated by EQ, so people with high EQ are affected less by sleep deprivation in such situations. Emotional Intelligence ( EI) often measured as an Emotional Intelligence Quotient ( EQ) describes an Ability, capacity Skill or (in ^[20]

Sleep deprivation due to long shifts has been implicated in a significant increase in medical errors over well-rested doctors. Medical Error is an inaccurate or incomplete diagnosis and/or Treatment of a Disease; Injury; Syndrome;

Obesity

Several large studies using nationally representative samples suggest that the obesity problem in Europe and the United States might have as one of its causes a corresponding decrease in the average number of hours that people are sleeping. Obesity is a condition in which excess Body fat has accumulated to such an extent that health may be negatively affected ^[21][22][23] The findings suggest that this might be happening because sleep deprivation could be disrupting hormones that regulate glucose metabolism and appetite. ^[24] The association between sleep deprivation and obesity appears to be strongest in young and middle-age adults. Other scientists hold that the physical discomfort of obesity and related problems, such as sleep apnea, reduce an individual's chances of getting a good night's sleep. Sleep apnea is a sleep disorder characterized by pauses in Breathing during Sleep.

Uses

Scientific study

In science, sleep deprivation (of rodents, e. g. ) is used in order to study the function(s) of sleep and the biological mechanisms underlying the effects of sleep deprivation. Sleep is a Natural state of bodily rest observed throughout the animal kingdom

Some sleep deprivation techniques are as follows:

• gentle handling (often require polysomnography): during the sleep deprivation period, the animal and its polygraph record are continuously observed; when the animal displays sleep electrophysiological signals or assumes a sleep posture, it is given objects to play with and activated by acoustic and if necessary tactile stimuli. See also Polysomnogram Polysomnography or PSG is a multi-parametric test used in the study of Sleep; the test result is called a ^[25] Although subjective,^[26] this technique is used for total sleep deprivation as well as REM or NREM sleep deprivation. The Sleep stages 1 through 4 are collectively referred to as NREM (non-rapid eye movement sleep

• single platform: probably one of the first scientific methods (see Jouvet, 1964 for cats^[27] and for rodents). During the sleep deprivation period, the animal is placed on an inverted flower pot whose bottom diameter is small relative to the animal size (usually 7 cm for adult rats); the pot is placed in a large tub filled with water to within 1 cm of the flower pot bottom. The animal is able to rest on the pot and is even able to get NREM sleep. But at the onset of REM sleep, with its ensuing muscular relaxation, it would either fall into the water and clamber back to its pot or would get its nose wet enough to waken it. So this technique is used only for REM sleep deprivation.
• multiple platform: in order to reduce the elevated stress response induced by the single platform method,^[28] developed this technique in which the animal is placed into a large tank containing multiple platforms, thus eliminating the movement restriction experienced in the single platform. This technique is also used only for REM sleep deprivation.
• modified multiple platform: modification of the multiple platform method where several animals together get the sleep deprivation (Nunes and Tufik, 1994).
• pendulum: animals are prevented from entering into PS by allowing them to sleep for only brief periods of time. This is accomplished by an apparatus which moves the animals' cages backwards and forwards like a pendulum. At the extremes of the motion postural imbalance is produced in the animals forcing them to walk downwards to the other side of their cages. ^[29]

Torture

Sleep deprivation is used as an interrogation technique (for example, in Pinochet-era Chile, the Soviet Union, and by coalition forces in Afghanistan and Iraq). Augusto José Ramón Pinochet Ugarte (November Chile, officially the Republic of Chile ( Spanish:) is a country in South America occupying a long and narrow Coastal strip wedged between the Multi-National Force - Iraq (MNF-I, is a military command, led by the United States that is fighting the Iraq War against Iraqi insurgents or resistants ^[30] Interrogation victims are kept awake for several days; when they are finally allowed to fall asleep, they are suddenly awakened and questioned. Menachem Begin, the Israeli prime minister from 1977-83 described his experience of sleep deprivation when a prisoner of the KGB in Russia as follows:

In the head of the interrogated prisoner, a haze begins to form. (מְנַחֵם בְּגִין Mieczysław Biegun Менахем Вольфович Бегин 16 August 1913 – 9 March 1992 was the sixth prime minister of the State of Israel His spirit is wearied to death, his legs are unsteady, and he has one sole desire: to sleep. . . Anyone who has experienced this desire knows that not even hunger and thirst are comparable with it.

In 2006, Australian Federal Attorney-General Philip Ruddock argued that sleep deprivation does not constitute torture. Philip Maxwell Ruddock (born March 12, 1943) is an Australian politician who served in various ministries in the Coalition Government of former Australian ^[31][32] In rats, prolonged, complete sleep deprivation increases both food intake and energy expenditure, leading to weight loss and, ultimately, death. ^[33] Nicole Bieske, a spokeswoman for Amnesty International Australia, has stated, "At the very least, [sleep deprivation] is cruel, inhumane and degrading. If used for prolonged periods of time it is torture. "^[30]

Treatment for depression

Recent studies show sleep deprivation has some potential in the treatment of depression. About 60% of patients, when sleep-deprived, show immediate recovery, with most relapsing the following night. The incidence of relapse can be decreased by combining sleep deprivation with medication ^[34]. Incidentally, many tricyclic antidepressants happen to suppress REM sleep, providing additional evidence for a link between mood and sleep ^[35]. Tricyclic antidepressants (abbreviation TCAs) are a class of Antidepressant drugs first used in the 1950s Similarly, tranylcypromine has been shown to completely suppress REM sleep at adequate doses. Tranylcypromine (sold under the brand name Parnate) is a Monoamine oxidase inhibitor (MAOI used as an Antidepressant drug.

Voluntary

Sleep deprivation may sometimes be intentionally induced for various reasons. For example, it may be induced as a form of recreation, entertainment or to provide a legal "high" without using drugs. Vivid hallucinations, heightened senses and a feeling of incredible creativity (common effects of illicit drugs) may occur after 48 hours (or less) of being in a state of sleeplessness. There is even a history of sleep deprivation being used by different schools of religious mystics as a form of asceticism or to heighten spiritual awareness. In particular, the early desert monks of the Christian Church during the fourth and fifth centuries were known to deny themselves sleep. Coffee owes much of its spread in popularity through use by Muslim mystics in all-night devotions. CoFFEE is an Open source Software for computer supported collaborative learning (CSCL in a digital classroom

Sleep deprivation has sometimes been self-imposed to achieve personal notoriety in the context of record-breaking stunts. A world record is the best performance in a certain discipline usually a Sports event One such record belonged to Randy Gardner, who stayed awake for 264 hours (eleven days even). Randy Gardner once held the scientifically documented record for the longest period of time a human being has intentionally gone without Sleep not using stimulants of any kind Lt. Cmdr. John J. Ross of the US Navy Medical Neuropsychiatric Research Unit later published an account of this event, which became well known among sleep-deprivation researchers.

Causes and treatments

School

In the United States, and in many other countries, sleep deprivation is common among students. The United States of America —commonly referred to as the ^[36]. School aged children should be getting between 8. 5 and 9. 25 hours of sleep^[37] but many do not. A National Sleep Foundation survey found that college/university-aged students get an average of 6. The National Sleep Foundation (NSF is an independent nonprofit organization dedicated to improving public health and safety by achieving understanding of Sleep and Sleep disorders 8 hours of sleep each night. ^[38] Partying, working, and a full class load are main contributing factors to sleep deprivation among college students. ^[39] Sleep deprivation is common in college freshmen especially, as they adjust to the stress and social activities of college life. A study performed by the Department of Psychology at the National Chung-Cheng University in Taiwan concluded that freshmen received the shortest amount of sleep during the week. ^[40]. Sleep deprivation has also been linked to the feared "freshman fifteen," as staying up later often leads to an increased food intake which ultimately causes weight gain. ^[39]. Students get more sleep each night in the summer than during the school year,^[41] and one in four US high school students admit to falling asleep in class at least once a week. ^[42]. Research has indicated that teenage children have a variation in their circadian cycle that delays sleep past the normal time for adults. Since school schedules are based around the adult workday, it is not surprising that students have difficulty obtaining adequate sleep. In 1997 the University of Minnesota did research that compared students who went to school at 7:15 and those who went to school at 8:40. The University of Minnesota Twin Cities ( U of M or The U) is the oldest and largest part of the University of Minnesota system. They found that students who went to school at 8:40 got higher grades and more sleep on the weekdays. ^[17]

Prevention of effects in soldiers

Since sleep deprivation is a fact of modern combat, the U.S. Army, through DARPA, has a "Preventing Sleep Deprivation Program", which has the goal to prevent the harmful effects of sleep deprivation and provide methods for recovery of function with particular emphasis on cognitive and psychomotor impairments. The United States Army is a military organization whose primary mission is to "provide necessary forces and capabilities. The Defense Advanced Research Projects Agency (DARPA is an agency of the United States Department of Defense responsible for the development of new Technology Their efforts include new pharmaceuticals that enhance neural transmission, nutraceuticals that promote neurogenesis, cognitive training, and devices such as transcranial magnetic stimulation. Nutraceutical, a Portmanteau of Nutrition and Pharmaceutical, refers to extracts of foods claimed to have a medicinal effect on human health Neurogenesis ( birth of Neurons ' is the process by which neurons are created Transcranial magnetic stimulation ( TMS) is a noninvasive method to excite neurons in the Brain: weak Electric currents are induced in the tissue by rapidly

Militaries of several countries, including the US, the UK, Pakistan and France, have been exploring the use of a drug called modafinil (sold as the brand Provigil in the United States), which has prevented negative effects of sleep deprivation. Modafinil ( Provigil) is a stimulant-like drug manufactured by Cephalon, and is approved by the FDA for the treatment of Narcolepsy Although modafinil is not a typical stimulant, it eliminates fatigue, promotes wakefulness, and improves alertness; it was initially developed for sufferers of narcolepsy. Narcolepsy is a Neurological condition most characterized by Excessive Daytime Sleepiness (EDS in which a person falls asleep during the day at inappropriate

See also

• Microsleep
• Insomnia
• Narcolepsy
• Fatigue
• Sleep debt
• Polyphasic sleep
• Sleep onset latency

References

External links

• National Sleep Foundation 2005 Sleep in America Poll (from the National Sleep Foundation)
• Brain activity is visibly altered following sleep deprivation
• Sleep deprivation effects on the activity of the hypothalamic spituitary adrenal and growth axes: potential clinical implications, by Alexandros N. Vgontzas, George Mastorakos, Edward O. Bixler, Anthony Kales, Philip W. Gold & George P. Chrousos
• How Much Sleep Do You Really Need?
• Calculate your Sleep Debt with this Sleep Debt Calculator
• Sleep deprivation & all-nighters on Google Groups
• World record attempt
• Live webcam of world record attempt

© 2009 citizendia.org; parts available under the terms of GNU Free Documentation License, from http://en.wikipedia.org
Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic