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Sevoflurane
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| Systematic (IUPAC) name | |
| 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane | |
| Identifiers | |
| CAS number | |
| ATC code | N01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C4H3F7O |
| Mol. mass | 200. IUPAC Nomenclature is a system of naming Chemical compounds and of describing the science of Chemistry in general CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs It is controlled by the WHO Collaborating Centre for Drug A section of the Anatomical Therapeutic Chemical Classification System. PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component The DrugBank database available at the University of Alberta is a unique Bioinformatics and Cheminformatics resource that combines detailed drug (i A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Carbon (kɑɹbən is a Chemical element with the symbol C and its Atomic number is 6 Hydrogen (ˈhaɪdrədʒən is the Chemical element with Atomic number 1 Fluorine, fluorum meaning "to flow" is the Chemical element with the symbol F and Atomic number 9 Oxygen (from the Greek roots ὀξύς (oxys (acid literally "sharp" from the taste of acids and -γενής (-genēs (producer literally begetteris the The molecular mass (abbreviated m of a substance, more commonly referred to as molecular weight and abbreviated as MW, is the Mass of one 055 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Sevoflurane (2,2,2-trifluoro-1-[trifluoromethyl]ethyl fluoromethyl ether), also called fluoromethyl hexafluoroisopropyl ether, is a sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. In Pharmacology, bioavailability is used to describe the fraction of an administered Dose of unchanged drug that reaches the Systemic circulation, one of Drug metabolism is the Metabolism of drugs, their Biochemical modification or degradation usually through specialized enzymatic systems The biological half-life of a substance is the time it takes for a substance (drug radioactive nuclide or other to lose half of its pharmacologic physiologic or radiologic activity Excretion is the process of eliminating waste products of Metabolism and other non-useful materials The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical if it is used as directed by the mother during The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction A prescription drug is a licensed medicine that is regulated by legislation to require a prescription before it can be obtained The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom, the UK or Britain,is a Sovereign state located A prescription drug is a licensed medicine that is regulated by legislation to require a prescription before it can be obtained The United States of America —commonly referred to as the In Pharmacology and Toxicology, a route In modern medical practice general anaesthesia ( AmE: anesthesia) is a state of total unconsciousness resulting from General anaesthetic drugs Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. Desflurane (222-trifluoro-1-fluoroethyl-difluoromethyl ether is a highly fluorinated methyl ethyl ether used for maintenance of General anaesthesia. Isoflurane (2-chloro-2-(difluoromethoxy-111-trifluoro-ethane is a Halogenated ether used for inhalational Anesthesia. Halothane vapour (or Fluothane) is an inhalational General anaesthetic. Anesthesia, or anaesthesia (see spelling differences; from Greek grc αν- an-, "without" and grc αἲσθησις It is often administered in a mixture of nitrous oxide and oxygen. Nitrous oxide, commonly known as " laughing gas," is a Chemical compound with the Chemical formula N 2 O. After desflurane it is the volatile anesthetic with the fastest onset and offset. Desflurane (222-trifluoro-1-fluoroethyl-difluoromethyl ether is a highly fluorinated methyl ethyl ether used for maintenance of General anaesthesia. The volatile anaesthetics are a class of General anaesthetic drugs Though desflurane has the lowest blood/gas coefficient of the currently used volatile anesthetics, sevoflurane is the preferred agent for mask induction due to its lesser irritation to mucous membranes.
Though it vaporizes readily, it is a liquid at room temperature and is administered via an anesthetic vaporizer attached to an anesthetic machine. An anaesthetic vaporiser is a device generally attached to an Anaesthetic machine which delivers a given concentration of a Volatile anaesthetic agent The anaesthetic machine (or anesthesia machine in America is used by Anaesthesiologists to support the administration of Anaesthesia.
It was introduced into clinical practice initially in Japan in 1990. The rights for sevoflurane in the US and other countries are held by Abbott Laboratories. Abbott Laboratories ( is a diversified pharmaceuticals Health care company
Sevoflurane forms at least two degradation products, Compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] and Compound B [1,1,1,3,3-pentafluoro-2-(fluoromethoxy)-3-methoxypropane], on contact with the soda lime in a rebreathing apparatus, which absorbs exhaled carbon dioxide, especially at higher temperatures and when the soda lime is desiccated. Soda lime is a mixture of Chemicals used in granular form in closed breathing environments such as General anaesthesia, Submarines Rebreathers A rebreather is a type of Breathing set that provides a Breathing gas containing Oxygen and recycled exhaled gas Carbon dioxide ( Chemical formula:) is a Chemical compound composed of two Oxygen Atoms covalently bonded to a single Compound A has been shown to cause renal necrosis in rats. In humans, direct histological evidence of renal toxicity has not been demonstrated, although there is dose-related proteinuria, glycosuria and enzymuria. Proteinuria (from protein and urine) means the presence of anexcess of serum Proteins in the Urine. Glycosuria or glucosuria is an abnormal condition of Osmotic Diuresis due to excretion of Glucose by the kidneys During low-flow anaesthesia, when the lower fresh gas flow leads to decreased flushing of the circuit and increased temperature of the soda lime, Compound A may build up to clinically significant levels. As a result, sevoflurane is sometimes administered with a minimum fresh gas flow of 2 liters per minute, making it a relatively expensive choice for maintaining general anesthesia.
Physical properties
| Boiling point: | 58. The boiling point of a liquid is the temperature at which the Vapor pressure of the liquid equals the environmental pressure surrounding the liquid 6 °C | (at 101. 325 kPa) | |
| Density: | 1. The density of a material is defined as its Mass per unit Volume: \rho = \frac{m}{V} Different materials usually have different 517–1. 522 g/cm³ | (at 20 °C) | |
| MAC : | 2 vol % | ||
| Molecular Weight: | 200 u | ||
| Vapor pressure: | 157 mmHg (20. Minimum alveolar concentration or MAC is a concept used to compare the strengths of anaesthetic vapours; in simple terms it is defined as the concentration of The molecular mass (abbreviated m of a substance, more commonly referred to as molecular weight and abbreviated as MW, is the Mass of one The unified atomic mass unit ( u) or Dalton ( Da) or sometimes universal mass unit, is an unit of Mass used to express Vapor pressure (also known as equilibrium vapor pressure or saturation vapor pressure) is the Pressure of a Vapor in equilibrium 9 kPa) | (at 20 °C) | |
| 197 mmHg (26. 3 kPa) | (at 25 °C) | ||
| 317 mmHg (42. 3 kPa) | (at 36 °C) | ||
| Blood:Gas Partition Coefficient: | 0. 68 | ||
| Oil:Gas Partition Coefficient: | 47 |
External links
Dictionary
sevoflurane
-noun
- A sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia.
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