Samuel Weiss is a Canadian neurobiologist. Country to "Dominion of Canada" or "Canadian Federation" or anything else please read the Talk Page Neuroscience is a field devoted to the scientific study of the nervous system
Weiss was an undergraduate at McGill University, where he received a B.Sc. in Biochemistry. A Bachelor of Science ( BS, BSc or BSc in the UK; less commonly S Biochemistry is the study of the chemical processes in living Organisms It deals with the Structure and function of cellular components such as He then went on to take his Ph.D. in Neurobiology at the University of Calgary. "PhD" redirects here for other uses see PhD (disambiguation. The University of Calgary is a research-intensive Public university in Calgary Alberta, Canada. From 1983 to 1988 he held two postdoctoral fellowships funded by the AHFMR and the Medical Research Council of Canada (now the Canadian Institutes of Health Research), the first at the Centre de Pharmacologie-Endocologie, Montpellier, France, and the second at the University of Vermont College of Medicine. Year 1983 ( MCMLXXXIII) was a Common year starting on Saturday (link displays the 1983 Gregorian calendar) Year 1988 ( MCMLXXXVIII) was a Leap year starting on Friday (link displays 1988 Gregorian calendar) Canadian Institutes of Health Research (CIHR is the major federal agency responsible for funding health research in Canada. Montpellier ( Occitan Montpelhièr) is a City in the south of France. This article is about the country For a topic outline on this subject see List of basic France topics. The University of Vermont is a national public research university and the state of Vermont's land-grant university
In 1985 Dr. Weiss and Dr Fritz Sladeczek discovered the metabotropic glutamate receptor, currently an extremely important area of research for neurological disorders. The metabotropic glutamate receptors, or mGluR s are a type of Glutamate receptor which are active through an indirect metabotropic process Dr. Weiss was appointed Assistant Professor and MRC Scholar at The University of Calgary in 1988. In 1992, while working at the University of Calgary, Dr. Weiss and graduate student Brent Reynolds found cells in the brains of mice that divided to produce new cells. They claimed that they successfully isolated stem cells and got them to divide and multiply in a lab dish. Stem cells are cells found in most if not all multi-cellular Organisms. The success of this experiment suggested that stem cells could be coaxed into producing new cells to replace damaged or destroyed brain cells. Currently Dr. Weiss is a Professor in the Department of Cell Biology & Anatomy/Pharmacology & Therapeutics and a member of the Genes and Development Research Group Faculty of Medicine University of Calgary. He is also the director of the Hotchkiss Brain Institute, sits on numerous national and international peer review committees, has authored many publications, holds key patents in the neural stem cell field and has founded two biotechnology companies. The second company, Stem Cell Therapeutics, is currently developing his discoveries for the treatment of various CNS disorders, including stroke.
His discovery of the metabotropic glutamate receptors opened a major new research area and currently the G-protein coupled metabotropic glutamate receptors (GRMs/mGluRs) have been implicated in the aetiology of schizophrenia, in amyloid beta-peptide toxicity, Creitzfeldt-Jakob disease and Fragile X syndrome. Schizophrenia ( from the Greek roots schizein (σχίζειν "to split" and phrēn Fragile X syndrome, or Martin-Bell syndrome, is a genetic Syndrome which results in a spectrum (from none to severe of characteristic physical intellectual emotional His discovery of adult mammalian central nervous system stem cells has generated two new and important perspectives. First, neural development continues throughout the lifetime of adult mammals. Second, insights into ongoing adult cell production will allow for the use of stem cells to repair neural tissue and allow for functional recovery from brain and spinal cord injury or disease. Nervous tissue is the fourth major class of Vertebrate tissue. Dr. Weiss has shown how prolactin increases the production of new brain cells and that new stem cell-generated brain cells can be redirected to part of the rodent brain that are damaged after stroke which results in partial improvement of the animals ability to move its limbs. Prolactin ( PRL) or Luteotropic hormone ( LTH) is a Peptide hormone primarily associated with Lactation. A stroke is the rapidly developing loss of brain functions due to a disturbance in the blood vessels supplying blood to the brain Currently he is trying to link the two to aid stroke recovery.
Bibliography
- Reynolds, B. A. and Weiss, S. (1992) “Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system” (Science 255, pp 1707–1710)
- Weiss, S. , Reynolds, B. A. , Vescovi, A. , Morshead, C. , Craig, C. G. , and van der Kooy, D. (1996) “Is there a stem cell in the mammalian forebrain?” (Trends in Neurosciences 19, pp 387–93)
- van der Kooy, D. and Weiss, S. (2000) “Why stem cells?” (Science 287, pp 1439–1441)
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