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Signal transducer and activator of transcription 6, interleukin-4 induced
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| Identifiers | ||
| Symbol(s) | STAT6; D12S1644; IL-4-STAT; STAT6B; STAT6C | |
| External IDs | OMIM: 601512 MGI: 103034 HomoloGene: 2373 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 6778 | 20852 |
| Ensembl | ENSG00000166888 | ENSMUSG00000002147 |
| Uniprot | P42226 | P70383 |
| Refseq | NM_003153 (mRNA) NP_003144 (protein) |
NM_009284 (mRNA) NP_033310 (protein) |
| Location | Chr 12: 55.78 - 55.79 Mb | Chr 10: 127.05 - 127.06 Mb |
| Pubmed search | [1] | [2] |
STAT6 is a STAT protein. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles The Signal Transducers and Activator of Transcription (STAT also called signal transduction and transcription protein s regulate many aspects of Cell growth, survival and
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. [1]
Contents |
See also
References
- ^ Entrez Gene: STAT6 signal transducer and activator of transcription 6, interleukin-4 induced. Interleukin-4, abbreviated IL-4, is a Cytokine that induces differentiation of naive helper T cells ( Th0 cells to Th2 cells Upon activation by
Further reading
- Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT. ". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. PMID 10856136.
- Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges. ". Gene 285 (1-2): 1–24. PMID 12039028.
- Hou J, Schindler U, Henzel WJ, et al. (1994). "An interleukin-4-induced transcription factor: IL-4 Stat. ". Science 265 (5179): 1701–6. PMID 8085155.
- Takeda K, Tanaka T, Shi W, et al. (1996). "Essential role of Stat6 in IL-4 signalling. ". Nature 380 (6575): 627–30. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 8602263.
- Shimoda K, van Deursen J, Sangster MY, et al. (1996). "Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. ". Nature 380 (6575): 630–3. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 8602264.
- Kotanides H, Reich NC (1996). "Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene. ". J. Biol. Chem. 271 (41): 25555–61. PMID 8810328.
- Mikita T, Campbell D, Wu P, et al. (1996). "Requirements for interleukin-4-induced gene expression and functional characterization of Stat6. ". Mol. Cell. Biol. 16 (10): 5811–20. PMID 8816495.
- Shen CH, Stavnezer J (1998). "Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription. ". Mol. Cell. Biol. 18 (6): 3395–404. PMID 9584180.
- Leek JP, Hamlin PJ, Bell SM, Lench NJ (1998). "Assignment of the STAT6 gene (STAT6) to human chromosome band 12q13 by in situ hybridization. ". Cytogenet. Cell Genet. 79 (3-4): 208–9. PMID 9605853.
- Mikita T, Kurama M, Schindler U (1998). "Synergistic activation of the germline epsilon promoter mediated by Stat6 and C/EBP beta. ". J. Immunol. 161 (4): 1822–8. PMID 9712049.
- Patel BK, Keck CL, O'Leary RS, et al. (1998). "Localization of the human stat6 gene to chromosome 12q13. 3-q14. 1, a region implicated in multiple solid tumors. ". Genomics 52 (2): 192–200. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9782085.
- Zhu M, John S, Berg M, Leonard WJ (1999). "Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. ". Cell 96 (1): 121–30. PMID 9989503.
- McDonald C, Reich NC (1999). "Cooperation of the transcriptional coactivators CBP and p300 with Stat6. ". J. Interferon Cytokine Res. 19 (7): 711–22. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10454341.
- Harris MB, Chang CC, Berton MT, et al. (2000). "Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching. ". Mol. Cell. Biol. 19 (10): 7264–75. PMID 10490661.
- Gupta S, Jiang M, Pernis AB (1999). "IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells. ". J. Immunol. 163 (7): 3834–41. PMID 10490982.
- Gupta S, Jiang M, Anthony A, Pernis AB (2000). "Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. ". J. Exp. Med. 190 (12): 1837–48. PMID 10601358.
- Daniel C, Salvekar A, Schindler U (2000). "A gain-of-function mutation in STAT6. ". J. Biol. Chem. 275 (19): 14255–9. PMID 10747856.
- Arinobu Y, Sugimoto R, Akaiwa M, et al. (2000). "Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells. ". Biochem. Biophys. Res. Commun. 277 (2): 317–24. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11032724.
- Masuda A, Matsuguchi T, Yamaki K, et al. (2001). "Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression. ". J. Biol. Chem. 276 (28): 26107–13. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11369758.
External links
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