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SMAD specific E3 ubiquitin protein ligase 2
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| PDB rendering based on 1zvd. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1zvd, 2djy | ||
| Identifiers | ||
| Symbol(s) | SMURF2; DKFZp686F0270; MGC138150 | |
| External IDs | OMIM: 605532 MGI: 1913563 HomoloGene: 41490 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 64750 | 66313 |
| Ensembl | ENSG00000108854 | ENSMUSG00000018363 |
| Uniprot | Q9HAU4 | n/a |
| Refseq | NM_022739 (mRNA) NP_073576 (protein) |
XM_001001801 (mRNA) XP_001001801 (protein) |
| Location | Chr 17: 59.97 - 60.09 Mb | Chr 11: 106.64 - 106.74 Mb |
| Pubmed search | [1] | [2] |
SMAD specific E3 ubiquitin protein ligase 2, also known as SMURF2, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
References
Further reading
- Lin X, Liang M, Feng XH (2001). "Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling. ". J. Biol. Chem. 275 (47): 36818-22. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11016919.
- Zhang Y, Chang C, Gehling DJ, et al. (2001). "Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. ". Proc. Natl. Acad. Sci. U. S. A. 98 (3): 974-9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11158580.
- Kavsak P, Rasmussen RK, Causing CG, et al. (2001). "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. ". Mol. Cell 6 (6): 1365-75. PMID 11163210.
- Bonni S, Wang HR, Causing CG, et al. (2001). "TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. ". Nat. Cell Biol. 3 (6): 587-95. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11389444.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Subramaniam V, Li H, Wong M, et al. (2003). "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. ". Br. J. Cancer 89 (8): 1538-44. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14562029.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40-5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Asano Y, Ihn H, Yamane K, et al. (2004). "Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts. ". J. Clin. Invest. 113 (2): 253-64. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14722617.
- Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. ". Oncogene 23 (10): 1801-8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14755250.
- Jin YH, Jeon EJ, Li QL, et al. (2004). "Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. ". J. Biol. Chem. 279 (28): 29409-17. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15138260.
- Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. ". Nat. Biotechnol. 22 (6): 707-16. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15146197.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway. ". Genome Res. 14 (7): 1324-32. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15231748.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. ". Genome Res. 14 (9): 1711-8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Zhang H, Cohen SN (2005). "Smurf2 up-regulation activates telomere-dependent senescence. ". Genes Dev. 18 (24): 3028-40. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15574587.
- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells. ". Science 307 (5715): 1621-5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15761153.
- Ohashi N, Yamamoto T, Uchida C, et al. (2005). "Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta. ". FEBS Lett. 579 (12): 2557-63. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15862290.
- Ogunjimi AA, Briant DJ, Pece-Barbara N, et al. (2005). "Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. ". Mol. Cell 19 (3): 297-308. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16061177.
- Chong PA, Lin H, Wrana JL, Forman-Kay JD (2006). "An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2. ". J. Biol. Chem. 281 (25): 17069-75. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16641086.
- Wiesner S, Ogunjimi AA, Wang HR, et al. (2007). "Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. ". Cell 130 (4): 651-62. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17719543.
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