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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
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| Identifiers | ||
| Symbol(s) | SMARCC1; BAF155; CRACC1; Rsc8; SRG3; SWI3 | |
| External IDs | OMIM: 601732 MGI: 1203524 HomoloGene: 68296 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 6599 | 20588 |
| Ensembl | ENSG00000173473 | ENSMUSG00000032481 |
| Uniprot | Q92922 | Q3UMX0 |
| Refseq | NM_003074 (mRNA) NP_003065 (protein) |
NM_009211 (mRNA) NP_033237 (protein) |
| Location | Chr 3: 47.6 - 47.8 Mb | Chr 9: 109.98 - 110.08 Mb |
| Pubmed search | [1] | [2] |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1, also known as SMARCC1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [1]
References
Further reading
- Wang W, Xue Y, Zhou S, et al. (1996). "Diversity and specialization of mammalian SWI/SNF complexes. ". Genes Dev. 10 (17): 2117–30. PMID 8804307.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery. ". Genome Res. 6 (9): 791–806. PMID 8889548.
- Wang W, Côté J, Xue Y, et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. ". EMBO J. 15 (19): 5370–82. PMID 8895581.
- Fryer CJ, Archer TK (1998). "Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex. ". Nature 393 (6680): 88–91. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9590696.
- Ring HZ, Vameghi-Meyers V, Wang W, et al. (1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. ". Genomics 51 (1): 140–3. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9693044.
- Cho H, Orphanides G, Sun X, et al. (1998). "A human RNA polymerase II complex containing factors that modify chromatin structure. ". Mol. Cell. Biol. 18 (9): 5355–63. PMID 9710619.
- Sif S, Stukenberg PT, Kirschner MW, Kingston RE (1998). "Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. ". Genes Dev. 12 (18): 2842–51. PMID 9744861.
- Shanahan F, Seghezzi W, Parry D, et al. (1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest. ". Mol. Cell. Biol. 19 (2): 1460–9. PMID 9891079.
- Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits. ". Mol. Cell 3 (2): 247–53. PMID 10078207.
- Kowenz-Leutz E, Leutz A (2000). "A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes. ". Mol. Cell 4 (5): 735–43. PMID 10619021.
- Bochar DA, Wang L, Beniya H, et al. (2000). "BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. ". Cell 102 (2): 257–65. PMID 10943845.
- Kadam S, McAlpine GS, Phelan ML, et al. (2000). "Functional selectivity of recombinant mammalian SWI/SNF subunits. ". Genes Dev. 14 (19): 2441–51. PMID 11018012.
- Xue Y, Canman JC, Lee CS, et al. (2001). "The human SWI/SNF-B chromatin-remodeling complex is related to yeast rsc and localizes at kinetochores of mitotic chromosomes. ". Proc. Natl. Acad. Sci. U. S. A. 97 (24): 13015–20. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11078522.
- Sif S, Saurin AJ, Imbalzano AN, Kingston RE (2001). "Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes. ". Genes Dev. 15 (5): 603–18. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11238380.
- Otsuki T, Furukawa Y, Ikeda K, et al. (2002). "Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex. ". Hum. Mol. Genet. 10 (23): 2651–60. PMID 11726552.
- Kato H, Tjernberg A, Zhang W, et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. ". J. Biol. Chem. 277 (7): 5498–505. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11734557.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Nie Z, Yan Z, Chen EH, et al. (2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. ". Mol. Cell. Biol. 23 (8): 2942–52. PMID 12665591.
- Kitagawa H, Fujiki R, Yoshimura K, et al. (2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. ". Cell 113 (7): 905–17. PMID 12837248.
- Hsiao PW, Fryer CJ, Trotter KW, et al. (2003). "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. ". Mol. Cell. Biol. 23 (17): 6210–20. PMID 12917342.
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