Citizendia
Your Ad Here

Sérgio Henrique Ferreira (b. April 10, 1934, Franca, São Paulo), Brazil, Brazilian physician and pharmacologist, noted for his discovery of Bradykinin potentiating factor, which led to better anti-hypertension drugs. Events 879 - Louis III becomes King of the Western Franks. 1407 - the lama Year 1934 ( MCMXXXIV) was a Common year starting on Monday (link will display full 1934 calendar of the Gregorian calendar. Franca is a Brazilian city in São Paulo state, located at 20º32'19"S 47º24'03'W at 1040 m altitude ( is a state in Brazil. It is the major industrial and economic powerhouse of the Brazilian economy |utc_offset = -2 to -4 |time_zone_DST = BRST |utc_offset_DST = -2 to -5 |cctld A physician, medical practitioner or medical doctor who practices Medicine, and is concerned with maintaining or restoring human Health Pharmacology (from Greek grc φάρμακον pharmakon, "drug" and grc -λογία -logia) is the study of how Drugs Hypertension, also referred to as high blood pressure, HTN or HPN, is a medical condition in which the Blood pressure is chronically elevated

Ferreira received his M.D. from the Faculty of Medicine of Ribeirão Preto of the University of São Paulo (USP) and soon became staff member of the same school, where he is presently a member of the Department of Pharmacology. Doctor of Medicine ( MD or MD, from the Latin Medicinæ Doctor meaning "Teacher of Medicine" is a doctoral Faculdade de Medicina de Ribeirão Preto (Faculty of Medicine of Ribeirão Preto in Portuguese) is a Medical school of the University of São Paulo (USP Pharmacology (from Greek grc φάρμακον pharmakon, "drug" and grc -λογία -logia) is the study of how Drugs His research training in pharmacology initiated in this Department with Prof. Maurício Rocha e Silva, the discoverer of bradykinin. Maurício Oscar da Rocha e Silva (b September 19, 1910, Rio de Janeiro; d Bradykinin is a Peptide that causes blood vessels to enlarge (dilate and therefore causes blood pressure to lower While working on this subject, he discovered a family of peptides present in the venom of a Brazilian snake, Bothrops jararaca, which inhibited kininase activity and strongly potentiated the effects of bradykinin in vivo and in vitro. Peptides (from the Greek πεπτίδια, "small digestibles" are short Polymers formed from the linking in a defined order of α- Amino Common names Jararaca yarara Bothrops jararaca is a venomous pitviper Species found in southern This factor was named bradykinin potentiating factor, BPF. In 1968, with the collaboration of Dr. Lewis Joel Greene, from the Brookhaven National Laboratory, U.S., he isolated several pharmacologically active peptides responsible for the activity of BPF. Lewis Joel Greene (b August 10, 1934, New York City, US) is an American-Brazilian Biochemist, Scientist, Brookhaven National Laboratory ( BNL) is a United States national laboratory located in Upton New York on Long Island, and was formally established The United States of America —commonly referred to as the Using those peptides, was demonstrated a general parallelism between bradykinin potentiation and inhibition of Angiotensin I conversion. Angiotensin causes blood vessels to constrict and drives blood pressure up Subsequently, his group elucidated the structure of the smallest peptide, and using the synthetic pentapeptide, demonstrated its hability to potentiate bradykinin and to inhibit the conversion of angiotensin I in vivo in experimental models of hypertension. His work in this area paved the way for the development of a new class of antihypertensive drugs, the converting enzymes inhibitors (ACE), by Squibb scientists. For this work with the Bothrops peptide he received the CIBA Award for Hypertension Research of 1983, together with Drs. Common names: lanceheads American lanceheads American lance-headed vipers E. Ondetti and D. Cushman from Squibb laboratories.

While working in London in the early seventies with John R. Vane (Nobel prize in Medicine, 1983), he participated in the discovery of the inhibition of the synthesis of prostaglandins by aspirin-like drugs. London ( ˈlʌndən is the capital and largest urban area in the United Kingdom. Sir John Robert Vane ( March 29, 1927 &ndash November 19, 2004) was a British Pharmacologist. The Nobel Prize (Nobelpriset (Nobelprisen is a Swedish prize established in the 1895 will of Swedish chemist Alfred Nobel; it was first awarded in Peace, Literature A prostaglandin is any member of a group of Lipid compounds that are derived enzymatically from Fatty acids and have important functions in the Animal body Aspirin, or acetylsalicylic acid (ASA (əˌsɛtɨlsælɨˌsɪlɨk ˈæsɨd is a Salicylate drug, often used as an Analgesic to relieve At that time, he proposed that the mechanism of the analgesic action of nonsteroidal antiinflammatory drugs (NSAID) was due to the prevention of pain receptor sensitization which results from an inhibition of the synthesis of prostaglandins. Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAID s or NAID s, are drugs with Analgesic, Antipyretic and in higher A nociceptor is a Sensory receptor that sends signals that cause the perception of Pain in response to a potentially damaging stimulus Sensitization is an example of non-associative Learning in which the progressive amplification of a response follows repeated administrations of a stimulus (Bell This hypothesis was supported by further work from his laboratory and from many other investigators. His studies on the basic mechanisms involved in the development of inflammatory hyperalgesia led to the discovery that a select class of analgesics like metamizole, in contrast to the classical non-steroidal antiinflammatory drugs, are able to counteract the ongoing sensitization of the primary sensory neuron via the stimulation of the arginine/nitric oxide pathway. Hyperalgesia is an increased sensitivity to Pain, which may be caused by damage to Nociceptors or Peripheral nerves. Metamizole sodium is a non-steroidal anti-inflammatory drug ( NSAID) commonly used in many countries as a powerful painkiller and fever reducer Arginine (abbreviated as Arg or R) is an α- Amino acid. The L-form is one of the 20 most common natural amino acids Nitric oxide or nitrogen monoxide is a Chemical compound with Chemical formula N[[Oxygen O]] He recently characterized a phenomenon described as retrograde sensitization of the primary sensory neuron, which emphasizes the importance of the peripheral component of the inflammatory pain. His group made a relevant contribution to the role of bradykinin and of cytokines in the development of inflammatory hyperalgesia. Cytokines are a category of signalling Proteins and Glycoproteins that like Hormones and Neurotransmitters, are used extensively in cellular He found that among the cytokines, interleukin 1 b mediates the endogenous release of prostaglandins and IL-8 is responsible for the development of the sympathetic hyperalgesia. Interleukins are a group of Cytokines (secreted Signaling molecules) that were first seen to be expressed by White blood cells ( Leukocytes hence In this area he described an antagonist of IL-1 that is now being developed as a model a new class of analgesics.

His contributions to science have been extensively recognized. Dr. Ferreira holds since 1995 the National Order of Scientific Merit in the Great Cross level, and received several awards and medals, such as from the Third World Academy of Sciences (1990 and 1992), the Mexican Prize of Science and Technology (199), the Rheimboldt-Hauptmann Prize of the University of São Paulo (2001) and the Péter Murányi Prize (2002). TWAS the academy of sciences for the developing world -- until 2004 named Third World Academy of Sciences -- is a merit-based science academy uniting more than 800 scientists He is in the editorial board of several international journals, is foreign member to the U. S. National Academy of Sciences. The National Academy of Sciences (NAS is a corporation in the United States whose members serve Pro bono as "advisers to the nation on science

Dr. Ferreira is also a noted scientific leader in Brazil. He helped to found and is one of the editors-in-chief of the most influential international biomedical scientific journal, Brazilian Journal of Medical and Biological Research, is a member of the Brazilian National Academy of Sciences and of the Brazilian Council of Science and Technology. The Brazilian Journal of Medical and Biological Research is a leading international Scientific periodical in the fields of Biology and Medicine, edited The Brazilian Academy of Sciences ( Portuguese: Academia Brasileira de Ciências or ABC) is the National academy of Brazil. The Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council of Scientific and Technological Development -- CNPq is an organization of the Brazilian He is founder and past president of the Brazilian Society for Pharmacology and Therapeutics and of the Brazilian Society for the Progress of Science (SBPC). Sociedade Brasileira para o Progresso da Ciência ( Portuguese for Brazilian Society for the Progress of Science) is a Brazilian Scientific society

Bibliography

Source

© 2009 citizendia.org; parts available under the terms of GNU Free Documentation License, from http://en.wikipedia.org
 Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic