Notions of race based on Human genetic variation have replaced historical approaches such as craniology with the advent of human genetics in the 20th century. The term race or racial group usually refers to the concept of categorizing Humans into Populations or groups on the basis of various sets Human genetic variation is the natural variation in gene frequencies observed between the genomes of individuals or groups of humans The historical definition of race was an immutable and distinct type or Species, sharing distinct racial characteristics such as constitution temperament Race and health research is mostly from the United States. It has found both current and historical racial differences in the frequency treatments and availability of treatments The study of race and intelligence is a controversial field which seeks to determine whether or not human intellectual abilities vary between races The modern controversy Social interpretation of physical variation Incongruities of racial classifications Even as the idea of "race" was becoming a powerful organizing principle in many List of racism-related topics|Racism by country Racism, by its simplest definition is the belief that race is the primary determinant of human traits and capacities and that Anti-miscegenation laws, also known as miscegenation laws, were laws that banned Interracial marriage and sometimes interracial sex between whites and members of other Racialism is an emphasis on race or racial considerations Racialism entails a belief in the existence and significance of racial categories but not necessarily in a Racial profiling is the inclusion of racial or ethnic characteristics in determining whether a person is considered likely to commit a particular type of crime or The United States is a racially diverse country There is an extensive history of race-based Slavery, the abolishment of it and its economic Brazil is a racially diverse and Multiracial country Intermarriage among different Ethnic groups has been part of the country's history Human evolution, or anthropogenesis, is the part of biological Evolution concerning the emergence of Homo sapiens as a distinct Species Genetics (from Ancient Greek grc-Latn genetikos, “genitive” and that from grc-Latn genesis, “origin” a discipline of Biology, is This is a list of topics related to Racism: A Affirmative action Afrocentrism Anti-Arabism The term race or racial group usually refers to the concept of categorizing Humans into Populations or groups on the basis of various sets Human genetic variation is the natural variation in gene frequencies observed between the genomes of individuals or groups of humans The historical definition of race was an immutable and distinct type or Species, sharing distinct racial characteristics such as constitution temperament Craniometry is the technique of measuring the Bones of the Skull. Human genetics describes the study of inheritance as it occurs in Human beings.

Early history

Blood groups

geographic distribution of blood group A

Prior to the discovery of DNA as the hereditary material, scientists used blood proteins to study human genetic variation. Research by Ludwik and Hanka Herschfeld during World War I found that the frequencies of blood groups A and B differed greatly from region to region. Ludwik Hirszfeld ( August 5[[ 884]] Warsaw &ndash March 7[[ 954]] Wroclaw) was a Polish microbiologist and a serologist World War I (abbreviated WWI; also known as the First World War, the Great War, and the War to End All A blood type (also called a blood group) is a classification of Blood based on the presence or absence of inherited Antigenic substances on the For example, among Europeans, 15% were group B and 40% were group A. Eastern Europeans and Russians had higher frequencies of group B, with people from India having the highest proportion. The Herschfelds concluded that humans were made of two different "biochemical races," each with its own origin. It was hypothesized that these two pure races later became mixed, resulting in the complex pattern of groups A and B. This was one of the first theories of racial differences to include the idea that visible human variation did not necessarily correlate with invisible genetic variation.

It was expected that groups that had similar proportions of the blood groups would be more closely related in racial terms, but instead it was often found that groups separated by large distances, such as those from Madagascar and Russia, had similar frequencies. This confounded scientists who were attempting to learn more about human evolutionary history. The next big advance in biological description of human variation would come with the discovery of more blood groups and proteins. ^[1]

Blood proteins and molecular evolution

Further information: molecular evolution

Techniques based on molecular evolution principles were used in early studies racial differences. Molecular evolution is the process of evolution at the scale of DNA, RNA, and Proteins Molecular evolution emerged as a scientific field in the 1960s as Molecular evolution is the process of evolution at the scale of DNA, RNA, and Proteins Molecular evolution emerged as a scientific field in the 1960s as One major technique in the field is to use mutations in individual proteins or genetic sequences as a molecular clock indicating the evolutionary relatedness of various species or groups. The molecular clock (based on the molecular clock hypothesis ( MCH) is a technique in Molecular evolution to relate the divergence time of two Species

Luigi Luca Cavalli-Sforza and Anthony Edwards would then incorporate these techniques into the field of population genetics. Luigi Luca Cavalli-Sforza (born January 25, 1922) is an Italian population geneticist born in Genoa, who has been a professor at Anthony William Fairbank Edwards (born 1935 is a British Statistician, Geneticist, and Evolutionary biologist. Population genetics is the study of the Allele frequency distribution and change under the influence of the four evolutionary forces Natural selection, Genetic Using computer based statistical analysis to average across the several blood group systems, they were able to produce a phylogenetic relationship of the various populations around the world.

In 1972 Richard Lewontin performed a statistical analysis of the data available on blood proteins. Richard Charles "Dick" Lewontin (born March 29, 1929) is an American Evolutionary biologist His results showed that the majority of genetic differences between humans, about 85%, were found within a population. 7% of genetic differences were found between populations within a race. Only 8% on average was found to differentiate the various races.

Non concordance

The most widely used human racial categories are based on various combinations of visible traits such as skin color, eye shape and hair texture. However, many of these traits are non-concordant in that they are not necessarily expressed together. For example skin color and hair texture vary independently. ^[2] This caused problems to early anthropologists who were attempting to classify race based on visible traits. Anthropology (/ˌænθɹəˈpɒlədʒi/ from Greek grc ἄνθρωπος anthrōpos, "human" -λογία -logia) is the study of Some examples of non-concordance include:

• There are many people in Africa and all over the world affected by albinism who have very light skin. Albinism (from Latin albus, "white" see extended etymology) is a form of hypopigmentary Congenital disorder,
• Skin color varies all over the world in different populations. People from the Indian subcontinent are classified as Caucasian but some have dark skin.
• Epicanthal fold are typically associated with East Asian populations but are found in populations all over the world, including many Native Americans, Southern Africans, the Saami, and even amongst some isolated groups such as the Andamanese, which can all be explained to genetically relate more closely to one another than to other populations, even neighboring ones, due to specific migrations. For indigenous peoples in the United States other than Hawaii and Alaska see also Native Americans in the United States. The Andamanese is a collective term to describe the peoples who are the aboriginal inhabitants of the Andaman Islands, located in the Bay of Bengal
• Lighter hair colors are associated with Europeans, especially Northern Europeans, but blond hair is found amongst a limited, small number of the dark skinned populations of the south pacific, particularly the Solomon Islands and Vanuatu. Hair color is the pigmentation of hair follicles due to the two types of melanin Eumelanin and Phaeomelanin. Blond (also spelled blonde, see below) or fair-haired is a Hair color characterized by low levels of the dark Pigment eumelanin The Solomon Islands is a country in Melanesia, east of Papua New Guinea, consisting of nearly one thousand islands Vanuatu, officially the Republic of Vanuatu ( French: République de Vanuatu, Bislama: Ripablik blong Vanuatu) is an Island

Human genetic variation

Main article: Human genetic variation

Human genetic variation is confined to approximately 0. Human genetic variation is the natural variation in gene frequencies observed between the genomes of individuals or groups of humans 1% of the total genetic composition. The most common polymorphisms (or genetic differences) in the human genome are single base-pair differences called single-nucleotide polymorphisms (SNPs). A single nucleotide polymorphism ( SNP, pronounced snip) is a DNA sequence variation occurring when a single Nucleotide - A, T About 99. 9% of the human genome is identical in all humans. On average there is only 0. 1% difference, which implies that the genomes of any two random humans are expected to differ by about 3 million base pairs. Of this 0. 1% difference, 85% is found within any given population, 7% is found between populations within a race and only 8% is found on average between the various races. Thus there is a claim that there is more genetic diversity within a race than between various races. However, this view has been criticised by Cambridge scientist Edwards, and is known as Lewontin's Fallacy, because the type of genetic difference between phenotypes is not entirely the same as that within phenotypes. Human Genetic Diversity Lewontin's Fallacy is a 2003 paper by A Compared with other species the amount of genetic diversity among humans is relatively small, but that is not to say that is not significant in terms of the effects of that difference. For example two random chimpanzee are expected to differ by about 1 in 500 DNA base pairs, equivalent to double the diversity amongst humans. This indicates that chimpanzees have existed as a species much longer than humans. ^[3]

Ancestry-informative marker are stretches of DNA which have several polymorphisms that exhibit substantially different frequencies between the different populations. ancestry-informative marker (AIM is a set of polymorphisms for a locus generally from humans which exhibits substantially different frequencies between populations from different geographical Using these AIMs scientists can determine a person's continent of origin based solely on their DNA. AIMs can also be used to determine someone's admixture proportions. ^[4]

Genetic variation is found also in genes, but at present this variation is poorly understood. Much of the variation is found the regions of the genome affected by the environment. A notable example is genes affecting physical appearance, in particular skin color. Human skin color can range from almost black (due to very high concentrations of the dark brown pigment melanin to nearly colorless (appearing reddish white due to the Blood Many of the genes regulating physical appearance have yet to be discovered. Genes related to the immunity system also show great variability with geographic location as a result of positive selection from the effects of regional diseases.

Models of genetic variation

There are several methods used to model human genetic variation. Genetic distance is a measure used to quantify the genetic differences between two populations. For 'genetic distance' in the context of a Genetic map, see Centimorgan Genetic distance is a measure of the dissimilarity of genetic It is based on the principle that two populations that share similar frequencies of a trait are more closely related than populations that have more divergent frequencies of a trait. In its simplest form it is the difference in frequencies of a particular trait between two populations. For example the frequency of RH negative individuals is 50. The term Rhesus (Rh blood group system refers to the 5 main Rhesus Antigens (C c D E and e as well as the many other less frequent Rhesus antigens 4% among Basques, is 41. The Basques (Euskaldunak are a people who inhabit a region spanning over parts of north-central Spain and southwestern France. 2% in France and 41. 1 in England. Thus the genetic difference between the Basques and French is 9. 2% and the genetic difference between the French and the English is 0. 1%for the RH negative trait. ^[5]

When only one trait is considered it often results in two very distant populations having little or no genetic difference. For example the frequency of blood group B allele in Russia is the same as in Madagascar indicating zero value for genetic distance. To adjust for these instances it is thus necessary to average values over several genetic systems. As DNA of all humans is 99. 9 percent the same the vast majority of traits show little genetic distance between the continents. However, for a few traits that are highly polymorphic genetic distances can be calculated and used to create phylogenetic relationships.

An Indigenous Australian , Melanesian, African Nilotic with eurasian blood and nom-bantoid and European mongolizated of North Baltic Sea. Indigenous Australians are descendants of the first known human inhabitants of the Australian continent and its nearby islands. Melanesia (from Greek: μέλας black, νῆσος island) means "islands of the black-skinned people" The European peoples are the various Nations and Ethnic groups of Europe. Though Oceanians resemble Africans they are the most genetically distant. Africans are more closely related to Europeans than any other group despite having different skin colors.

Historically people have chosen spouses from nearby villages. Hence genetic distance is largely related to geographic distance between populations. ^[6] Genetic distance may also occur due to physical boundaries that restrict gene flow such as Islands cut off by rising seas.

A study by Cavalli-Sforza using 120 blood polymorphisms provides information on genetic distances of the various continents. Luigi Luca Cavalli-Sforza (born January 25, 1922) is an Italian population geneticist born in Genoa, who has been a professor at ^[7]

The largest genetic distance between any two continents is between Africa and Oceania at 24. 7. Based on physical appearance this may be counterintuitive, since Australians and New Guineans resemble Africans with dark skin and sometimes frizzy hair. This resemblance is probably an example of convergent evolution. Convergent evolution describes the acquisition of the same biological trait in unrelated lineages This large figure for genetic distance reflects the relatively long Isolation of Australia and New Guinea since the end of the Last glacial maximum when the continent was further isolated from mainland Asia due to rising sea levels.

The next largest genetic distance is between Africa and the Americas at 22. 6%. This is expected since the longest geographic distance by land is between Africa and South America. The shortest genetic distance at 8. 9% is between Asia and the Americas indicating a more recent separation.

Africans are the most divergent continent with all other groups being more related to each other than to Africa. This is expected in accordance with the Recent single-origin hypothesis. In Paleoanthropology, the recent African origin of modern humans is one of two hypotheses of the origin of anatomically modern humans Homo sapiens sapiens The population most closely related to Africans are Europeans. However, this short distance indicates significant interaction and gene exchange between Africa and Europe in the not so distant past. Europe has a genetic variation in general about three times less than that of other continents. Even though Europeans are the non-African group closest to Africans, Europeans are most closely related to East Asians. As the genetic distance from Africa to Europe (16. 6) is shorter than the genetic distance from Africa to East Asia (20. 6) Cavalli-Sforza proposes that both Asian and African populations contributed to the settlement of Europe which began 40,000 years ago. The overall contributions from Asia and Africa were estimated to be around two-thirds and one-third, respectively. Europe has a genetic variation in general about three times less than that of other continents. ^[8]

Factors influencing genetic diversity

Selection

Positive selection plays an important role in shaping genetic variation. Population genetics, directional selection occurs when Natural selection favors a single Phenotype and therefore Allele frequency continuously Most notably is its role in influencing physical appearance. Dark skin appears to be under strong selection because the protein that causes it varies very little in African populations but is free to vary in populations found outside Africa. This indicates that dark skin was selected to protect against the harmful effects of UV radiation that cause birth defects due to destruction of vitamin b folate. Ultraviolet ( UV) light is Electromagnetic radiation with a Wavelength shorter than that of Visible light, but longer than X-rays Folic acid (also known as Vitamin M and Folacin) and Folate (the Anionic form are forms of the water-soluble Vitamin B9 UV radiation also causes sunburn and skin cancer. When people left the sun intensive regions of Africa the protein was free to vary as a result lighter skin color reemerged in populations around the world. ^[9] Immunoglobulins or antibodies are also under strong selection in response to local diseases. Antibodies (also known as immunoglobulins, abbreviated Ig) are Gamma globulin Proteins that are found in Blood or other Bodily For example people who are duffy negative tend to have higher resistance to malaria. The Duffy antigen is a protein located on the outside of Red blood cells and is named after the patient in which it was discovered Most Africans are duffy negative and most Europeans are duffy positive. ^[10]

Native Americans are almost exclusively Blood group O at about 98%. Some scientists believe this widespread distribution indicates strong selection, possibly resistance to syphilis. Syphilis is a Sexually transmitted disease caused by the spirochetal Bacterium Treponema pallidum pallidum. During the European invasion of the Americas, millions of Native Americans were decimated because of diseases they were not immune to such as smallpox and influenza. Europeans had become resistance to these disease after suffering several series of deadly plagues (such as the Plague of Justinian and the Black death). The Plague of Justinian was a Pandemic that afflicted the Byzantine Empire, including its capital Constantinople, in the years 541 – 542 The Black Death, or the Black Plague, was one of the deadliest Pandemics in human history widely thought to have been caused by a bacterium named Yersinia In turn the Europeans contracted syphilis to which they had no immunity.

Genetic drift

Genetic drift is the random change in gene frequencies between generations. In Population genetics, genetic drift is the accumulation of random events that change the makeup of a gene pool slightly but often compound over time By chance, a few individuals may leave behind more descendants and thus genes than other individuals. The genes of the next generation will be the genes of the “lucky” individuals, not necessarily the healthier or “better” individuals.

Founder effect

Simple illustration of founder effect. The original population is on the left with three possible founder populations on the right.

The founder effect is the establishment of a new population by a few original founders which carry only a small fraction of the total genetic variation of the parental population. In Population genetics, the founder effect refers to the loss of genetic variation when a new colony is established by a very small number of individuals from a larger As a result, the new population may be distinctively different, both genetically and phenotypically, from the parent population from which it is derived. Some scientists speculate that the ubiquity of Blood group O amongst native Americans is an example of a strong founder effect. They argue that a small band of Asian people who crossed the Bering strait into Alaska may have been predominantly Blood group O.

Founder effects are notable following the colonization of Islands. The crania of Indigenous Australians is one of the most differentiated from other populations and is the most easily identified due to more prominent brow ridges. The supraorbital ridge or brow ridge refer to a bony ridge located above the eye sockets of all Primates In Homo sapiens sapiens (modern man the Since the crania shows little variability amongst Australians some scientists believe it arose from a founding effect. ^[11]

Gene flow between continents

Gene flow is the exchange of genes from one population to another. In Population genetics, gene flow (also known as gene migration) is the transfer of Alleles of Genes from one Population to another Gene flow has the effect of reducing the genetic distance between two populations. Since genes are exchanged between neighboring populations many traits are distributed along clines. The boundaries of the major continents may in some cases restrict gene flow, allowing for genetic differentiation.

However many of the political divisions of today are not naturally occurring and in the past have not restricted gene flow. Europe and Asia are in fact the single continent of Eurasia. This would explain the relatively small genetic distance of 9. 7% as calculated by Cavalli-Sforza.

Controversially North Africa is sometimes included as Part of Eurasia. Northeast Africa is adjacent to Saudi Arabia and thus Africans have a long history of interaction with the middle east. Populations in the horn of Africa have significant Arab admixture. African mitochondrial DNA haplotypes are also frequent in the Middle east. Across the Sahara from Sudan to Senegal interactions between blacks and Arabs have resulted in significant gene exchange between the populations. 20% of North Africans have sub-saharan African mitochondrial DNA haplogroups. In the study of Molecular evolution, a haplogroup, from "ἁπλο-" (Greek haplo-: simple or single + "group" is a group of similar Haplotypes During the 8th century the Moors from North Africa conquered the Iberian peninsula, in the process they would have brought African admixture to Europe. The Iberian Peninsula, or Iberia, is located in the extreme southwest of Europe, and includes modern day Spain, Portugal, Andorra Sub-Saharan DNA admixture in Europe refers to the way in which Sub-Saharan African DNA is lightly scattered throughout the European continent. Studies have shown about 4% of the population in Spain and Portugal have sub-Saharan mtDNA haplogroups. This is clinically distributed across Europe from southwest to North east with Northern Europe showing no presence.

Africa is the most genetically divergent continent. However, the most closely related population to Africa based on genetic distance is Europe at 16. 6%. This may be counterintuitive based on different skin colors. Independent evolution on the different continents would result in equal genetic distances between Africa and the other continents. However, this low figure of 16. 6(relative to Australia 24. 7, and America 22. 6%) indicates that there has been substantial interaction and exchange of genes between Africa and Europe. Cavalli-Sforza estimates that Europeans are mixed race population, one third African and two thirds Asian. ^[5][7]

Joseph Greenberg classified American languages into three large families. Joseph Harold Greenberg (May 28 1915 – May 7 2001 was a prominent and controversial linguist and Africanist anthropologist known for his work in both typology He proposed that these families represent three separate migrations that filled the Americas in the order they arrived. These separate migrations across the Bering strait would have continued to bring new genes from Asia thus reducing the genetic distance between Asia and America.

Australasia is largely considered to be the most isolated continent. It was occupied at least 40,000 years ago when sea levels were much lower and the shortest distance between Indonesia and Australia was a 90 km sea voyage. 20,000 years ago at the end of the last Glacial Maximum, sea levels rose due to melting ice sheets flooding much of Australia's coastline and increasing its geographic isolation from Asia. Tasmania was cut off from Australia 10,000 years ago making it the most isolated region. These obstacles significantly restricted gene flow to indigenous Australasians. Second to Africa, Australasia is the most genetically divergent continent by genetic distance; however evidence suggests that even with Australasia gene flow has been taking place. Fossils of the Dingo in Australia have been dated to only 3500 years ago indicating that it was recently introduced. FOSSIL is a standard protocol for allowing serial communication for Telecommunications programs under the DOS Operating system. Description Appearance Adult dingoes are typically 48–58 cm (19–23 inches tall at the shoulders and weigh on average 23–32 kgs (50–70 pounds though specimens The dingo is native to India. Some Y chromosomal studies indicate a recent influx of y chromosomes from the Indian subcontinent. The Y chromosome is the sex-determining Chromosome in most Mammals including Humans In mammals it contains the gene SRY, which triggers ^[12] More recently fisherman from Makassar in Indonesia regularly made contact with Indigenous Australians from possibly as early as 1000 CE. Macassan Trepangers from the southwest corner of Sulawesi (formerly Cele bes visited the coast of northern Australia for hundreds of years to fish for trepang (also

Recent admixture

Main article: Miscegenation#Genetic studies of racial admixture

Genetic techniques have been used to study racial admixture in America. Miscegenation (Latin miscere "to mix" + genus "kind" is the mixing of different racial groups, that is marrying, cohabiting

Defining race

The 0. 1% genetic difference that differentiates any two random humans is still the subject of much debate. The discovery that only 8% of this difference separates the major races led some scientists to proclaim that race is biologically meaningless. They argue that since genetic distance increases in a continuous manner any threshold or definitions would be arbitrary. Any two neighboring villages or towns will show some genetic differentiation from each other and thus could be defined as a race. Thus any attempt to classify races would be imposing an artificial discontinuity on what is otherwise a naturally occurring continuous phenomenon.

However, other scientists disagree by claiming that the assertion that race is biologically meaningless is politically motivated and that genetic differences are significant. Neil Risch states that numerous studies over past decades have documented biological differences among the races with regard to susceptibility and natural history of a chronic disease, though acknowledges that these differences do not constitute any major subdivisions of the human species: '. Neil Risch is an American human Geneticist and professor at the University of California San Francisco (UCSF . . These conclusions seem consistent with the claim that "there is no biological basis for 'race'" and that "the myth of major genetic differences across 'races' is nonetheless worth dismissing with genetic evidence". Of course, the use of the term "major" leaves the door open for possible differences but a priori limits any potential significance of such differences. ' Effectively Neil Risch is attempting to redefine "race" for human populations to represent that small proportion of variation that is known to vary between continental populations. It is well established, that the level of differentiation between the continental human groups, as measured by the statistic F_ST is about 0. 06-0. 1 (6-10%), with about 5-10% of variation at the population level (that is between different populations occupying the same continent) and about 75-85% of variation within populations. (Risch et al. , 2002; Templeton, 1998; Ossorio and Duster, 2005; Lewontin, 2005). Tempeton (1998) states that in biology a level of 0. 25-0. 3 (20-30%) of differentiation normally accepted in biological literature for a population to be considered a race or subspecies.

"A standard criterion for a subspecies or race in the nonhuman literature under the traditional definition of a subspecies as a geographically circumbscribed, sharply differentiated population is to have F_ST values of at least 0. 25 to 0. 3 (Smith et al. 1997). Hence as judged by the criterion in the nonhuman literature, the human F_ST value is too small to have taxonomic significance under the traditional subspecies definition. "(Templeton, 1998)

Indeed Neil Risch himself avoids defining race, when asked to respond to the comment "Genome variation research does not support the existence of human races. ” he replied

What is your definition of races? If you define it a certain way, maybe that's a valid statement. There is obviously still disagreement. . . . Scientists always disagree! A lot of the problem is terminology. I'm not even sure what race means, people use it in many different ways. (Gitschier, 2005)

Racial classification is a modern phenomenon dating back to the 15th century when Portuguese and Spanish sailors encountered sub-saharan Africans and referred to them as Negro (the color black). Negro is a term referring to people of Black African ancestry Literature from earlier Roman and Greek eras is noticeably lacking in racial references. Ancient Rome was a Civilization that grew out of a small agricultural community founded on the Italian Peninsula as early as the 10th century BC The Culture of Greece has evolved over thousands of years with its beginnings in the Mycenaean and Minoan Civilizations, continuing most notably into Classical Greece Instead people were often described by their tribal origin or by their status as freemen or slaves.

Clusters controversy

Infobox Multi Locus Allele Clusters In a haploid population, when a single locus is considered (blue), with two alleles, wild-type (+) and mutant (-) we can see a differential geographical distribution between Population I and Population II, but there is a 30% chance of wrongly assigning any individual to either population based on a single allele. "Haplo" redirects here For the fictional character see The Death Gate Cycle. × + - Population I 70% 30% Population II 30% 70% For three loci blue, red and green, it becomes apparent that there is a correlation between certain allele frequencies. In this example Population I displays a correlation between wild-type blue (+) 70%, mutant red (-) 70% and wild type green (+) 70%. Population II has a correlation between the -, + and - alleles, each having a 70% frequency in this population. The genetic variation remains the same in these populations, irresepctive of the allele examined, but using a three locus approach, there is a much reduced chance of wrongly assigning any individual to a given population. × + - + - + - Population I 70% 30% 30% 70% 70% 30% Population II 30% 70% 70% 30% 30% 70% For an organism of genotype +/-/+, for each locus the chance of missclassification is 0. 3 (30%), but when all three loci are take into account, the organism can be assigned to Population I with a 0. 3x0. 3x0. 3 chance of error, that is a 0. 027 (2. 7%) chance of error. The two populations still share exactly the same alleles, but the frequency of these alleles varies between the populations. Using modern computer software and the abundance of genetic data now available, it is possible not only to distinguish such correlations for hundreds or even thousands of alleles, which form clusters, it is also possible to assign individuals to given populations with very little chance of error. It should be noted, however, that genes tend to vary clinally, and there are likely to be intermediate populations that reside in the geographical areas between our sample populations (Population III, for example, may lie equidistantly from Population I and Population II). In this case it may well be that Population III may display characteristics of both population I and Population II. For example Population III may be defined thus: × + - + - + - Population III 50% 50% 50% 50% 50% 50% In which case any individual from Population III is likely to be misclassified equally into either Population I or Population II. (Edwards (2003)Kittles and Weiss (2003))

A computer program called STRUCTURE is used by some scientists to determine clusters of human populations. It is a statistical program that works by placing individuals into one of two clusters based on their overall genetic similarity, many possible pairs of clusters are tested per individual to generate multiple clusters. ^[13] These populations are based on multiple genetic markers that are often shared between different human populations even over large geographic ranges. The notion of a genetic cluster is that people within the cluster share on average similar allele frequencies to each other than to those in other clusters. (Edwards, 2003)

The results obtained by clustering analyses are dependent on several criteria:

• The clusters produced are relative clusters and not absolute clusters, each cluster is the product of comparisons between sets of data derived for the study, results are therefore highly influenced by sampling strategies. (Edwards, 2003)
• The geographic distribution of the populations sampled, because human genetic diversity is marked by isolation by distance, populations from geographically distant regions will form much more discrete clusters than those from geographically close regions. (Kittles and Weiss, 2003)
• The number of genes used. The more genes used in a study the greater the resolution produced and therefore the greater number of clusters that will be identified. (Tang, 2005)

A study by Noah Rosenberg and Jonathan K. Noah Rosenberg is a geneticist working in Evolutionary biology, Human Genetics, and Population genetics, now Pritchard, geneticists from the laboratory of Marcus W. Feldman of Stanford University, assayed 377 polymorphisms (ie gene types) in more than 1,000 people from 52 ethnic groups in Africa, Asia, Europe and the Americas. Leland Stanford Junior University, commonly known as Stanford University or simply Stanford, is a private Research university located in They concluded that without using prior information about the origins of individuals, they were able to identify six main genetic clusters, five of which correspond to major geographic regions, and subclusters that often correspond to individual populations. The clusters corresponded to Africa, Europe and the part of Asia south and west of the Himalayas, East Asia, Oceania, the Kalash (of Pakistan) and the Americas. The Kalash ( Nuristani: Kasivo) or Kalasha, are an ethnic group of the Hindu Kush mountain range residing in the Chitral district (Rosenberg, 2002 and Rosenberg, 2005)

Distribution of European clusters identified by Bauchet. When two clusters are identified there is a north-southeast cline that may be due to demic diffusion during the European Neolithic

Another study by Neil Risch in 2005 used 326 microsatellite markers and self-identified race/ethnic group (SIRE), white, African-American, Asian and Hispanic (individuals involved in the study had to choose from one of these categories), to representing discrete "populations", and showed distinct and non-overlapping clustering of the white, African-American and Asian samples. Demic diffusion is a Demographic term referring to a migratory model developed by Cavalli-Sforza, that consists of population Diffusion into and across Neolithic Europe is the time between roughly from 7000 BC (the approximate time of the first farming societies in Greece) to ca Neil Risch is an American human Geneticist and professor at the University of California San Francisco (UCSF Microsatellites, or Simple Sequence Repeats (SSRs are polymorphic loci present in nuclear and organellar DNA that consist of repeating The results confirmed the integrity of self-described ancestry: "We have shown a nearly perfect correspondence between genetic cluster and SIRE for major ethnic groups living in the United States, with a discrepancy rate of only 0. 14%. " But also warned that: "This observation does not eliminate the potential for confounding in these populations. First, there may be subgroups within the larger population group that are too small to detect by cluster analysis. Second, there may not be discrete subgrouping but continuous ancestral variation that could lead to stratification bias. For example, African Americans have a continuous range of European ancestry that would not be detected by cluster analysis but could strongly confound genetic case-control studies. " (Tang, 2005)

Additionally two studies of European population clusters have been produced. Seldin et al. (2006) identified three European clusters using 5,700 genome-wide polymorphisms. Bauchet et al. (2007) used 10,000 polymorphisms to identify five distinct clusters in the European population, consisting of a south-eastern European cluster (including samples from southern Italians, Armenian, Ashkenazi Jewish and Greek "populations"); a northern-European Cluster (including samples from German, eastern English, Polish and western Irish "populations"); a Basque cluster (including samples from Basque "populations"); a Finnish cluster (including samples from Finnish "populations") and a Spanish cluster (including samples from Spanish "populations"). Ashkenazi Jews, also known as Ashkenazic Jews or Ashkenazim ( Hebrew: אַשְׁכֲּנָזִים, ˌaʃkəˈnazim sing Most "populations" contained individuals from clusters other than the dominant cluster for that population, there were also individuals with membership of several clusters. The results of this study are presented on a map of Europe. (Bauchet, 2007)

Criticism of the clusters study

Though the authors of the study do not equate the clusters with race there are some who view the studies on clusters as evidence of the existence of biological races. Hence these studies have attracted considerable controversy. Critics argue that using genetic information to determine an individual's continent of origin is not a new concept. Using the ABO, RH and MNS blood groups, scientists in the 1950s could already determine continent of origin based on known frequencies of these traits. The MNS antigen system is a human blood group system based upon genes on Chromosome 4.

Critics argue that any attempt to divide humanity will always produce artificial results. They point to the fact that in the study when six clusters were used an additional cluster (race) appeared which consisted solely of the Kalash of Pakistan. The Kalash ( Nuristani: Kasivo) or Kalasha, are an ethnic group of the Hindu Kush mountain range residing in the Chitral district Several groups in the study also appeared in two races such as Ethiopians, Hazara of Pakistan, and Uyghur from Pakistan and western China. The Hazāra ( are a Persian-speaking people residing in the central region of Afghanistan and northwestern Pakistan. The Uyghur (also spelled Uygur, Uighur, Uigur, Uyghur: ئۇيغۇر) are a Turkic people of Central Asia. Joseph Graves argues that in the study the people sampled were from regions separated by large distances such as South African Bantu and Russians. Joseph L Graves, Jr is Dean of University Studies and Professor of Biological Studies at North Carolina Agricultural and Technical State University. He argues that if more people came from the regions that bridge the continents results may have been different. Examples such as Armenians would cluster both with Asia and Europe. The Armenians (Հայեր Hayer) are a Nation and Ethnic group originating in the Caucasus and in the Armenian Highlands A large Somalians or Yemenites may cluster both with Africa and Europe. Somalia ( Soomaaliya; الصومال) officially the Somali Republic ( Jamhuuriyadda Soomaaliya, جمهورية الصومال) and formerly known

Others say the bulk of human variation is continuously distributed and, as a result, any categorization schema attempting to meaningfully partition that variation will necessarily create artificial truncations. It is for this reason, they argue, that attempts to allocate individuals into ancestry groupings based on genetic information have yielded varying results that are highly dependent on methodological design. ^[14]

Nicholas Wade, who often cites the work of clusters in articles for the New York Times, says that even if individuals can be assigned to continent of origin based on their genotype (genes), this is not an indication of phenotype. Nicholas Wade is a British-born scientific reporter editor and author who currently writes for the Science Times section of The New York Times. The genotype is the genetic constitution of a cell an organism or an individual (i A phenotype is any observable characteristic of an Organism, such as its morphology, Development, biochemical or physiological properties This is because the SNPs used in the clustering study are selectively neutral i. e. stretches of Junk DNA that have no known function. In Molecular biology, junk DNA is a provisional label for the portions of the DNA sequence of a Chromosome or a Genome for which no Since they do not code for any protein or have regulatory function, mutations can occur without interfering in normal cell function. Over time these mutations can accumulate much quicker in local populations and thus they can be used to identify continent of origin. Therefore these SNPS that can be used to differentiate continental populations are not known to influence intelligence, behavior, susceptibility to disease or ability in sports. Wade argues that it is possible that even though the sites used are nonworking sections of DNA, mutations in them may serve as a proxy for mutations in genes that influence intelligence and behaviour. However, he admits that at the moment there is no known relationship between mutations in junk DNA and mutations in genes.

Complexities of the human genome

Many human phenotypes are polygenic, meaning that they depend on the interaction among many genes. Inheritance of quantitative traits or polygenic inheritance refers to the inheritance of a phenotypic characteristic that varies in degree and can be attributed to Polygeneity makes the study of individual phenotypic differences more difficult. Additionally, phenotypes may be influenced by environment as well as by genetics. The measure of the genetic role in phenotypes is heritability. In Genetics, Heritability is the proportion of phenotypic variation in a population that is attributable to genetic variation among individuals

Different genes may also produce the same phenotype. For example the gene that causes light skin in Europeans is different than the gene that causes light skin in East Asians. Europeans have a different version of the SLC24A5 than East Asians possibly indicating that they evolved light skin independently. SLC24A5 ( solute carrier family 24 member 5) is a Gene that is thought to explain between 25 and 38% of Skin pigmentation variation between Black In a recent asthma study found that genes that defined susceptibility to asthma in blacks were different than the genes defined susceptibility in whites which were again different for the genes that defined susceptibility to asthma in Hispanics.

Epigenetic inheritance describes a phenomenon where traits are passed on to the next generation based on environmental effects or experience. In Biology, the term epigenetics refers to changes in Gene expression caused by mechanisms other than changes in the underlying DNA sequence These traits are inherited without being written into the DNA sequence. In some cases traits are passed on to the next generation by the switching off or on of various genes that are already present. The implication of this is that having the same genotype at a locus does not necessarily mean having the same phenotype.

Popular beliefs about race and genetics

In his book Guns, Germs, and Steel, Jared Diamond argues that European explorers believed that differences between European societies and American societies could be explained by differences in innate biological ability. Guns Germs and Steel The Fates of Human Societies is a 1997 book by Jared Diamond, professor of Geography and Physiology at UCLA TemplateInfobox writer --> Jared Mason Diamond (b 10 September, 1937) is an American Evolutionary biologist Darwinian evolution viewed the "primitive societies" to be vestiges of human descent from apelike ancestors. Finally in the 20th century, with the rise of genetics, Europeans came to be viewed as genetically superior than Africans and Australian aboriginals.

See also

• Human mitochondrial DNA haplogroups
• Human Y-chromosome DNA haplogroup
• Genetic history of Europe

Footnotes

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External links

• Minorities, Race, and Genomics via Human Genome Project information. The Human Genome Project (HGP was an international Scientific research project with a primary goal to determine the sequence of chemical base pairs which make up DNA