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Related RAS viral (r-ras) oncogene homolog
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| PDB rendering based on 2fn4. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 2fn4 | ||
| Identifiers | ||
| Symbol(s) | RRAS; | |
| External IDs | OMIM: 165090 MGI: 98179 HomoloGene: 4565 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 6237 | 20130 |
| Ensembl | ENSG00000126458 | ENSMUSG00000038387 |
| Uniprot | P10301 | Q3U1N3 |
| Refseq | NM_006270 (mRNA) NP_006261 (protein) |
NM_009101 (mRNA) NP_033127 (protein) |
| Location | Chr 19: 54.83 - 54.84 Mb | Chr 7: 44.89 - 44.89 Mb |
| Pubmed search | [1] | [2] |
Related RAS viral (r-ras) oncogene homolog, also known as RRAS, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
References
Further reading
- Lowe DG, Capon DJ, Delwart E, et al. (1987). "Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes. ". Cell 48 (1): 137-46. PMID 3098437.
- Carboni JM, Yan N, Cox AD, et al. (1995). "Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation. ". Oncogene 10 (10): 1905-13. PMID 7761092.
- Spaargaren M, Bischoff JR (1995). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap. ". Proc. Natl. Acad. Sci. U. S. A. 91 (26): 12609-13. PMID 7809086.
- Fernandez-Sarabia MJ, Bischoff JR (1993). "Bcl-2 associates with the ras-related protein R-ras p23. ". Nature 366 (6452): 274-5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 8232588.
- Linnemann T, Geyer M, Jaitner BK, et al. (1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily. ". J. Biol. Chem. 274 (19): 13556-62. PMID 10224125.
- Choy E, Chiu VK, Silletti J, et al. (1999). "Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. ". Cell 98 (1): 69-80. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10412982.
- Zou JX, Wang B, Kalo MS, et al. (2000). "An Eph receptor regulates integrin activity through R-Ras. ". Proc. Natl. Acad. Sci. U. S. A. 96 (24): 13813-8. PMID 10570155.
- Wang B, Zou JX, Ek-Rylander B, Ruoslahti E (2000). "R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras. ". J. Biol. Chem. 275 (7): 5222-7. PMID 10671570.
- Suzuki J, Kaziro Y, Koide H (2000). "Positive regulation of skeletal myogenesis by R-Ras. ". Oncogene 19 (9): 1138-46. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10713701.
- Ohba Y, Mochizuki N, Yamashita S, et al. (2000). "Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3. ". J. Biol. Chem. 275 (26): 20020-6. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10777492.
- Yuryev A, Ono M, Goff SA, et al. (2000). "Isoform-specific localization of A-RAF in mitochondria. ". Mol. Cell. Biol. 20 (13): 4870-8. PMID 10848612.
- Oertli B, Han J, Marte BM, et al. (2000). "The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function. ". Oncogene 19 (43): 4961-9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11042683.
- Tian X, Feig LA (2002). "Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors. ". J. Biol. Chem. 276 (50): 47248-56. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11560935.
- Ortiz-Vega S, Khokhlatchev A, Nedwidek M, et al. (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. ". Oncogene 21 (9): 1381-90. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11857081.
- Yu Y, Feig LA (2002). "Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells. ". Oncogene 21 (49): 7557-68. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12386818.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Kwong L, Wozniak MA, Collins AS, et al. (2003). "R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins. ". Mol. Cell. Biol. 23 (3): 933-49. PMID 12529399.
- Rincón-Arano H, Rosales R, Mora N, et al. (2003). "R-Ras promotes tumor growth of cervical epithelial cells. ". Cancer 97 (3): 575-85. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12548599.
- Furuhjelm J, Peränen J (2004). "The C-terminal end of R-Ras contains a focal adhesion targeting signal. ". J. Cell. Sci. 116 (Pt 18): 3729-38. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12890755.
- Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. ". J. Biol. Chem. 279 (21): 22353-61. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15031288.
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