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Ribophorin II
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| Identifiers | ||
| Symbol(s) | RPN2; RIBIIR; RPN-II; RPNII; SWP1 | |
| External IDs | OMIM: 180490 MGI: 98085 HomoloGene: 2214 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 6185 | 20014 |
| Ensembl | ENSG00000118705 | ENSMUSG00000027642 |
| Uniprot | P04844 | Q3U505 |
| Refseq | NM_002951 (mRNA) NP_002942 (protein) |
XM_977943 (mRNA) XP_983037 (protein) |
| Location | Chr 20: 35.24 - 35.3 Mb | Chr 2: 156.97 - 157.02 Mb |
| Pubmed search | [1] | [2] |
Ribophorin II, also known as RPN2, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. [1]
References
Further reading
- Stoffel M, Xiang K, Bell GI (1993). "Dinucleotide repeat polymorphism at the human ribophorin II locus (RPN2) on chromosome 20q. ". Hum. Mol. Genet. 1 (8): 656. PMID 1301181.
- Löffler C, Rao VV, Hansmann I (1991). "Mapping of the ribophorin II (RPN II) gene to human chromosome 20q12-q13. 1 by in-situ hybridization. ". Hum. Genet. 87 (2): 221–2. PMID 2066112.
- Crimaudo C, Hortsch M, Gausepohl H, Meyer DI (1987). "Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins. ". EMBO J. 6 (1): 75–82. PMID 3034581.
- Kumar V, Heinemann FS, Ozols J (1998). "Interleukin-2 induces N-glycosylation in T-cells: characterization of human lymphocyte oligosaccharyltransferase. ". Biochem. Biophys. Res. Commun. 247 (2): 524–9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9642163.
- Fu J, Kreibich G (2000). "Retention of subunits of the oligosaccharyltransferase complex in the endoplasmic reticulum. ". J. Biol. Chem. 275 (6): 3984–90. PMID 10660554.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20. ". Nature 414 (6866): 865–71. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11780052.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. ". Nat. Biotechnol. 21 (5): 566–9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12665801.
- Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R (2003). "Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. ". Mol. Cell 12 (1): 101–11. PMID 12887896.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Shibatani T, David LL, McCormack AL, et al. (2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. ". Biochemistry 44 (16): 5982–92. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15835887.
- Tu LC, Yan X, Hood L, Lin B (2007). "Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. ". Mol. Cell Proteomics 6 (4): 575–88. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17220478.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry. ". Mol. Syst. Biol. 3: 89. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17353931.
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