Synthetic prostaglandin analogues are molecules which are manufactured to bind to a prostaglandin receptor. There are currently nine known prostaglandin receptors on various cell types
Wider use of prostaglandin analogues is limited by unwanted side effects and their abortive potential. An
Uses
- Prostaglandin analogues such as misoprostol are used in treatment of duodenal and gastric ulcers. Misoprostol is a drug that is FDA -approved in the United States for the prevention of non-steroidal anti-inflammatory drug ( NSAID)-induced In Anatomy of the Digestive system, the duodenum is a hollow jointed tube about 25-30 cm (10-12 in long connecting the Stomach to the Jejunum A peptic ulcer, also known as PUD or peptic ulcer disease, is an Ulcer (defined as mucosal erosions equal to or greater than 0 They exert antisecretory and cytoprotective properties and are especially indicated for the elderly on continuous doses of NSAIDs. Old age consists of ages nearing or surpassing the Average life span of Human beings and thus the end of the human life cycle. Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAID s or NAID s, are drugs with Analgesic, Antipyretic and in higher
- Prostaglandin analogues can also be used in the management of open-angle glaucoma. Glaucoma is a group of diseases of the Optic nerve involving loss of retinal ganglion cells in a characteristic pattern of optic neuropathy. They reduce intra-ocular pressure by enhancing uveoscleral outflow and may also have some effect on the trabecular meshwork as well. The trabecular meshwork is an area of tissue in the Eye located around the base of the Cornea, near the Ciliary body, and is responsible for draining the Latanoprost, travoprost, unoprostone and bimatoprost are examples of prostaglandin analogues used in the management of open-angle glaucoma. Latanoprost (pronounced la-TA-noe-prost) ophthalmic solution is a topical medication used for controlling the progression of Glaucoma or ocular Hypertension Travoprost ophthalmic solution is a topical medication used for controlling the progression of Glaucoma or ocular Hypertension, by reducing Intraocular pressure Unoprostone ( INN) is a Prostaglandin analogue. Its Isopropyl Ester, unoprostone isopropyl, is marketed under the trade name Rescula Bimatoprost (sold in the US and Canada by Allergan, under the trade name Lumigan) is a Prostamide used topically (as Eye drops to control the In some countries such as Australia, they are now considered first line agents in open-angle glaucoma (rather than beta-blockers)[1]
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