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Pantoprazole
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| Systematic (IUPAC) name | |
| 5-(difluoromethoxy)- 2-[(3,4-dimethoxypyridin-2-yl) methylsulfinyl]- 3H-benzoimidazole | |
| Identifiers | |
| CAS number | |
| ATC code | A02 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C16H15F2N3O4S |
| Mol. mass | 383. IUPAC Nomenclature is a system of naming Chemical compounds and of describing the science of Chemistry in general CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs It is controlled by the WHO Collaborating Centre for Drug ATC code A02 is a division of the Anatomical Therapeutic Chemical Classification System and part of the A Alimentary tract and metabolism. PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component The DrugBank database available at the University of Alberta is a unique Bioinformatics and Cheminformatics resource that combines detailed drug (i A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Carbon (kɑɹbən is a Chemical element with the symbol C and its Atomic number is 6 Hydrogen (ˈhaɪdrədʒən is the Chemical element with Atomic number 1 Fluorine, fluorum meaning "to flow" is the Chemical element with the symbol F and Atomic number 9 Nitrogen (ˈnaɪtɹəʤɪn is a Chemical element that has the symbol N and Atomic number 7 and Atomic weight 14 Oxygen (from the Greek roots ὀξύς (oxys (acid literally "sharp" from the taste of acids and -γενής (-genēs (producer literally begetteris the Sulfur or sulphur (ˈsʌlfɚ see spelling below) is the Chemical element that has the Atomic number 16 The molecular mass (abbreviated m of a substance, more commonly referred to as molecular weight and abbreviated as MW, is the Mass of one 371 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | 77% |
| Metabolism | Hepatic (CYP2C19 and 3A4) |
| Half life | 1 hour |
| Excretion | Renal |
| Therapeutic considerations | |
| Licence data |
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| Pregnancy cat. | |
| Legal status |
℞ Prescription only |
| Routes | Oral and intravenous |
Pantoprazole (brand names Pantopan in Italy; Protium; Protonix; Pantozol; Pantor; Pantoloc; Astropan; Controloc; Pantecta;Inipomp) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. In Pharmacology, bioavailability is used to describe the fraction of an administered Dose of unchanged drug that reaches the Systemic circulation, one of Drug metabolism is the Metabolism of drugs, their Biochemical modification or degradation usually through specialized enzymatic systems The liver is a vital organ in the human body and is present in Vertebrates and some other animals Cytochrome P450 2C19 (abbreviated CYP2C19) a member of the Cytochrome P450 mixed-function oxidase system is involved in the metabolism of Xenobiotics Cytochrome P450 3A4 (abbreviated CYP3A4) ( a member of the Cytochrome P450 mixed-function oxidase system is one of the most important enzymes involved in the metabolism The biological half-life of a substance is the time it takes for a substance (drug radioactive nuclide or other to lose half of its pharmacologic physiologic or radiologic activity Excretion is the process of eliminating waste products of Metabolism and other non-useful materials The kidneys are complicated organs that have numerous biological roles The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical if it is used as directed by the mother during For a topic outline on this subject see List of basic Australia topics. The United States of America —commonly referred to as the The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction In Pharmacology and Toxicology, a route Intravenous therapy or IV therapy is the giving of Liquid substances directly into a Vein. Proton pump inhibitors (or "PPI"s are a group of drugs whose main action is pronounced and long-lasting reduction of Gastric acid production Gastroesophageal reflux disease ( American English and Canadian English) or Gastro-oesophageal reflux disease ( British English, Hiberno-English Initial treatment is generally of eight weeks' duration, after which another eight week course of treatment may be considered if necessary. It can be used as a maintenance therapy for long term use after initial response is obtained. This medication may affect the results of certain lab tests (e. g. false positive urine screen for tetrahydrocannabinal-THC). It is recommended you make sure laboratory personnel and your doctor know you are using this drug. The active ingredient in PROTONIX (pantoprazole sodium) Delayed-Release Tablets is a substituted benzimidazole , sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]-1 H -benzimidazole sesquihydrate, a compound that inhibits gastric acid secretion.
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Pharmacology
Pantoprazole is metabolized in the liver by the cytochrome P450 system. Cytochrome P450 (abbreviated CYP, P450, infrequently CYP450) is a very large and diverse superfamily of Hemoproteins found in all Domains Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation. Demethylation is the chemical process resulting in the removal a Methyl group (CH3 from a molecule Cytochrome P450 2C19 (abbreviated CYP2C19) a member of the Cytochrome P450 mixed-function oxidase system is involved in the metabolism of Xenobiotics Sulfation refers to the process whereby a Lead-acid battery (such as a Car battery) loses its ability to hold a charge after it is kept in a discharged state too long Another metabolic pathway is oxidation by CYP3A4. Cytochrome P450 3A4 (abbreviated CYP3A4) ( a member of the Cytochrome P450 mixed-function oxidase system is one of the most important enzymes involved in the metabolism Pantoprazole metabolites are not thought to have any pharmacological significance. Pantoprazole is relatively free of drug interactions.
Availability
Pantoprazole was developed by Altana and is currently marketed under the brand name Protonix by Wyeth-Ayerst Laboratories, Somac by Pfizer, Astropan by Astron Lifesciences , Pantor by Bosnalijek, and as Pantoloc by Solvay Pharma, as Protium in the UK, as Inipomp in France, and as TopZole in South Africa. Altana Kuyavian-Pomeranian Voivodeship This article is about the corporation Wyeth, formerly known as American Home Products (AHP is one of the largest pharmaceutical companies in the world Pfizer Incorporated ( is a major Pharmaceutical company, which ranks number one in the world in sales Bosnalijek is the biggest Pharmaceutical company in Bosnia and Herzegovina. It is manufactured by a joint venture company Zydus Altana Private Limited which was formed by Altana and Cadila Healthcare. Altana Kuyavian-Pomeranian Voivodeship This article is about the corporation Cadila Healthcare is an Indian pharmaceutical company headquartered at Ahmedabad in Gujarat state of western India. The plant is located at Thane, Maharashtra 421305, India. WikipediaWikiProject Indian cities for details --> Thane ( Marathi / Konkani: ठाणे (formerly Thana) is a city in Maharashtra Maharashtra ( Marathi: mahārāṣṭra, IPA) is a state located on the western coast of India. It is available by prescription in delayed-release tablets. It is also available for intravenous use.
On December 24, 2007, Teva Pharmaceutical released an AB-rated generic alternative to Protonix. Teva Pharmaceutical Industries Ltd (טבע תעשיות פרמצבטיות בע"מ is an international Pharmaceutical company headquartered in Petah Tikva [1]
External links
References
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