PNPase can refer to:

• Polynucleotide Phosphorylase - an RNA degrading protein
• Purine nucleoside phosphorylase - an enzyme involved in purine metabolism

Polynucleotide Phosphorylase ( PNPase) is bifunctional Enzyme with a phosphorolytic 3' to 5' Exoribonuclease activity and a 3'-terminal Oligonucleotide Purine nucleoside phosphorylase (also known as PNPase) is an Enzyme ( involved in purine metabolism.

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