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Purinergic receptor P2Y, G-protein coupled, 12
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| Identifiers | ||
| Symbol(s) | P2RY12; ADPG-R; HORK3; P2T(AC); P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; SP1999 | |
| External IDs | OMIM: 600515 MGI: 1918089 HomoloGene: 11260 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 64805 | 70839 |
| Ensembl | ENSG00000169313 | ENSMUSG00000036353 |
| Uniprot | Q9H244 | Q546L4 |
| Refseq | NM_022788 (mRNA) NP_073625 (protein) |
NM_027571 (mRNA) NP_081847 (protein) |
| Location | Chr 3: 152.54 - 152.59 Mb | Chr 3: 59.3 - 59.35 Mb |
| Pubmed search | [1] | [2] |
In the field of molecular biology, the P2Y12 protein is a chemoreceptor for adenosine diphosphate (ADP) and is found on the cell surface of blood platelet cells. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles Molecular biology is the study of Biology at a molecular level Proteins are large Organic compounds made of Amino acids arranged in a linear chain and joined together by Peptide bonds between the Carboxyl A chemosensor, also known as chemoreceptor, is a Sensory receptor that transduces a chemical signal into an Action potential. Adenosine diphosphate, abbreviated ADP, is a Nucleotide. It is an Ester of Pyrophosphoric acid with the Nucleoside Adenosine Blood is a specialized Bodily fluid that delivers necessary substances to the body's cells €”such as nutrients and oxygen—and transports Waste products Platelets, or Thrombocytes, are small cytoplasmic bodies derived from cells They circulate in the Blood of Mammals and are involved [1][2]
The P2Y12 protein belongs to a group of G protein-coupled purinergic receptors[3] and is an important regulator in blood platelet coagulation. G protein-coupled receptors ( GPCRs) also known as seven transmembrane domain receptors, 7TM receptors, heptahelical receptors, and Purinergic receptors are a family of newly characterized Plasma membrane molecules involved in several and as yet only partially known cellular functions such as vascular reactivity [4]
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene. [5]
Clinical significance
The drug clopidogrel binds to this receptor and is marketed as a platelet anticoagulant. Clopidogrel is a potent oral antiplatelet agent often used in the treatment of Coronary artery disease, Peripheral vascular disease, and Cerebrovascular [1] In an April 2006 article, a team of researchers published a study of the role of platelet-transported serotonin in liver regeneration in which this method of platelet anticoagulant therapy was used. Serotonin (ˌsɛrəˈtoʊnən ( 5-hydroxytryptamine, or 5-HT) is a Monoamine Neurotransmitter synthesized in serotonergic Neurons The liver is a vital organ in the human body and is present in Vertebrates and some other animals [6]
References
- ^ a b Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, Yang RB, Nurden P, Nurden A, Julius D, Conley PB (2001). "Identification of the platelet ADP receptor targeted by antithrombotic drugs". Nature 409 (6817): 202–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11196645.
- ^ Nicholas RA (2001). "Identification of the P2Y(12) receptor: a novel member of the P2Y family of receptors activated by extracellular nucleotides". Mol. Pharmacol. 60 (3): 416–20. PMID 11502870.
- ^ Murugappa S, Kunapuli SP (2006). "The role of ADP receptors in platelet function". Front. Biosci. 11: 1977–86. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16368572.
- ^ Dorsam RT, Kunapuli SP (2004). "Central role of the P2Y12 receptor in platelet activation". J. Clin. Invest. 113 (3): 340–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14755328.
- ^ Entrez Gene: P2RY12 purinergic receptor P2Y, G-protein coupled, 12.
- ^ Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, Gachet C, Bader M, Clavien PA (2006). "Platelet-derived serotonin mediates liver regeneration". Science 312 (5770): 104–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16601191.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain. Medical Subject Headings ( MeSH) is a huge Controlled vocabulary (or metadata system for the purpose of indexing journal articles and books The United States National Library of Medicine ( NLM) operated by the United States federal government, is the world's largest Medical library. The public domain is a range of abstract materials &ndash commonly referred to as Intellectual property &ndash which are not owned or controlled by anyone
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