Osseointegration is the direct structural and functional connection between living bone and the surface of a load-bearing artificial implant, typically made of titanium. Bones are rigid organs that form part of the Endoskeleton of Vertebrates They function to move support and protect the various organs of the body produce An implant is a Medical device made to replace and act as a missing biological structure (as compared with a transplant, which indicates transplanted Biomedical Titanium (taɪˈteɪniəm is a Chemical element with the symbol Ti and Atomic number 22 It is a property virtually unique to titanium and hydroxylapatite, and has enhanced the science of medical bone, and joint replacement techniques. Hydroxylapatite, also called hydroxyapatite, is a Mineral. It is a naturally occurring form of calcium Apatite with the formula Ca5(PO43(OH Medicine is the art and science of healing It encompasses a range of Health care practices evolved to maintain and restore Human Health by the Joint replacement is one of the most common and successful operations in modern Orthopaedic surgery.
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Two theories regarding the chemical mechanism by which endosteal implants integrate with bone have been proposed:
Branemark proposed that implants integrate such that the bone is laid very close to the implant without any intervening connective tissue. The titanium oxide permanently fuses with the bone, as Branemark showed in 1950s. Titanium dioxide, also known as titanium(IV oxide or titania, is the naturally occurring Oxide of Titanium, chemical formula Ti[[oxygen Osseointegration can be defined as,
Branemark also stated that the implant should not be loaded and left out of function during the healing period for osseous integration to occur.
Weiss' theory states that there is a fibro-osseous ligament formed between the implant and the bone and this ligament can be considered as the equivalent of the periodontal ligament found in the gomphosis. Gomphosis is a synarthrosis (joint that binds the teeth to bony sockets ( dental alveoli) in the maxillary bone and Mandible. He defends the presence of collagen fibres at the bone-implant interface. Collagen is the main Protein of Connective tissue in Animals and the most abundant protein in Mammals making up about 50% of the whole-body protein He interpreted it as the peri-implantal ligament with an osteogenic effect. He advocates the early loading of the implant.
In 1985, Dr. C. de Putter proposed two ways of implant anchorage or retention as mechanical and bioactive. Mechanical retention can be achieved in cases where the implant material is a metal, for example, commercially pure titanium and titanium alloys. In these cases, topological features like vents, slots, dimples, threads (screws), etc. aid in the retention of the implant. There is no chemical bonding and the retention depends on the surface area: the greater the surface area, the greater the contact.
Bioactive retention can be achieved in cases where the implant is coated with bioactive materials such as hydroxyapatite. Hydroxylapatite, also called hydroxyapatite, is a Mineral. It is a naturally occurring form of calcium Apatite with the formula Ca5(PO43(OH These bioactive materials stimulate bone formation leading to a physico-chemical bond. The implant is ankylosed with the bone. Ankylosis, or Anchylosis (from Greek αγκυλος bent crooked is a stiffness of a Joint, the result of Injury or Disease.