 |
|
|
Methylprednisolone
|
|
| Systematic (IUPAC) name | |
| (6α, 11β)-11,17,21-trihydroxy-6-methyl-pregna-1,4-diene-3,20 -dione | |
| Identifiers | |
| CAS number | |
| ATC code | D07 D07AC14, D10AA02, H02AB04 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C22H30O5 |
| Mol. mass | 374. IUPAC Nomenclature is a system of naming Chemical compounds and of describing the science of Chemistry in general CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs It is controlled by the WHO Collaborating Centre for Drug A section of the Anatomical Therapeutic Chemical Classification System. A section of the Anatomical Therapeutic Chemical Classification System. A section of the Anatomical Therapeutic Chemical Classification System. A section of the Anatomical Therapeutic Chemical Classification System. PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component The DrugBank database available at the University of Alberta is a unique Bioinformatics and Cheminformatics resource that combines detailed drug (i A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Carbon (kɑɹbən is a Chemical element with the symbol C and its Atomic number is 6 Hydrogen (ˈhaɪdrədʒən is the Chemical element with Atomic number 1 Oxygen (from the Greek roots ὀξύς (oxys (acid literally "sharp" from the taste of acids and -γενής (-genēs (producer literally begetteris the The molecular mass (abbreviated m of a substance, more commonly referred to as molecular weight and abbreviated as MW, is the Mass of one 471 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | 78% |
| Metabolism | liver primarily, kidney, tissues; CYP450: 3A4 substrate |
| Half life | urine; Half-life: 18-26h (biological) |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
C |
| Legal status | |
| Routes | IV, IM, IV Infusion, oral |
Methylprednisolone (molecular weight 374. In Pharmacology, bioavailability is used to describe the fraction of an administered Dose of unchanged drug that reaches the Systemic circulation, one of A drug's efficiency may be affected by the degree to which it binds to the proteins within Blood plasma. Drug metabolism is the Metabolism of drugs, their Biochemical modification or degradation usually through specialized enzymatic systems The biological half-life of a substance is the time it takes for a substance (drug radioactive nuclide or other to lose half of its pharmacologic physiologic or radiologic activity Excretion is the process of eliminating waste products of Metabolism and other non-useful materials The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical if it is used as directed by the mother during The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction In Pharmacology and Toxicology, a route 471) is a synthetic glucocorticoid drug taken orally or administered intravenously. Glucocorticoids (GC are a class of Steroid hormones characterised by an ability to bind with the glucocorticoid receptor ( GR) and trigger similar effects Its chemical name is pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-6-methyl-,(6α, 11β)- and its chemical formula is C22H30O5. Methylprednisolone is sold in the USA and Canada under the brand names Medrol and Solu-Medrol. [1]
Like most adrenocortical steroids, methylprednisolone is typically used for its anti-inflammatory effects. Corticosteroids are a class of Steroid hormones that are produced in the Adrenal cortex. However, glucocorticoids have a wide range of effects, including changes to metabolism and immune responses. The list of medical conditions for which methlyprednisolone is prescribed is rather large, and is similar to other corticosteroids such as prednisolone. Corticosteroids are a class of Steroid hormones that are produced in the Adrenal cortex. Prednisolone is the active metabolite of Prednisone. Uses It is a Corticosteroid drug with predominantly Glucocorticoid and low Mineralocorticoid Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. Arthritis (from Greek arthro-, joint + -itis, inflammation plural arthritides is a group of conditions involving damage to the Joints of the body The bronchioles or bronchioli are the first Airway branches that no longer contain Cartilage. Inflammation ( Latin, inflamatio, to set on fire is the complex biological response of vascular tissues to harmful stimuli such as Pathogens Bronchitis is an Inflammation of the large bronchi (medium-sized airways in the Lungs It can progress to Pneumonia. It is used both in the treatment of acute periods and long-term controlling of autoimmune diseases, most notably SLE. Autoimmune diseases arise from an overactive Immune response of the body against substances and tissues normally present in the body Systemic lupus erythematosus ( SLE or lupus,) is a chronic autoimmune disease that can be fatal though with recent medical advances fatalities are becoming
Methylprednisolone has serious side effects if taken long-term, including weight gain, glaucoma, osteoporosis and psychosis, especially when overdosed. Glaucoma is a group of diseases of the Optic nerve involving loss of retinal ganglion cells in a characteristic pattern of optic neuropathy. Osteoporosis is a Disease of Bone that leads to an increased risk of fracture. Psychosis (from the Greek ψυχή "psyche" for mind or soul and -οσις "-osis" for abnormal condition with adjective psychotic The term drug overdose (or simply overdose or OD) describes the Ingestion or application of a Drug or other substance in quantities The most serious side effect occurs after the adrenal glands cease natural production of cortisone, which methylprednisolone will replace. Cortisone (ˈkɔrtɨsoʊn or /ˈkɔrtɨzoʊn/ (ˈkôrtəˌsōn or -zōn (17-hydroxy-11-dehydrocorticosterone is a Steroid Hormone. Abrupt cessation of the drug after this occurs can result in a condition known as Addisonian crisis, which can be fatal. Addison's disease (also known as chronic Adrenal insufficiency, '''hypocortisolism''' or '''hypocorticism) is a rare Endocrine disorder To prevent this, the drug is usually prescribed with a tapering dosage, including a pre-dosed "dose pack" detailing a specific number of pills to take at designated times over a six day period.
Alternative treatments to many of the conditions currently indicated for methlyprednisolone are actively being researched. Additionally, new drugs such as budesonide are being created, which provide similar benefits but without the adrenal suppression problems. Budesonide is a Glucocorticoid Steroid for the treatment of Asthma, non-infectious Rhinitis (including Hay fever and other allergies
References
Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic