| Mannose | |
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| Identifiers | |
| CAS number | [31103-86-3] |
| PubChem | |
| MeSH | |
| Properties | |
| Molecular formula | C6H12O6 |
| Molar mass | 180. CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to PubChem is a Database of chemical Molecules The system is maintained by the National Center for Biotechnology Information (NCBI a component Medical Subject Headings ( MeSH) is a huge Controlled vocabulary (or metadata system for the purpose of indexing journal articles and books A chemical formula is a way of expressing information about the Atoms that constitute a particular Chemical compound, and how the relationship between those atoms changes Molar mass, symbol M, is the Mass of one mole of a substance ( Chemical element or Chemical compound) 156 |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Mannose is a sugar monomer of the hexose series of carbohydrates. In Chemistry, the standard state of a material is its state at 1 bar (100 Kilopascals exactly Sugar is a class of edible Crystalline substances mainly Sucrose, Lactose, and Fructose. A monomer (from Greek mono "one" and meros "part" is a small Molecule that may become chemically bonded to other In Organic chemistry, a hexose is a Monosaccharide with six Carbon atoms having the Chemical formula C6H12O6 Carbohydrates (from ' Hydrates of Carbon ' or saccharides ( Greek σάκχαρον meaning " Sugar " are the most
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Metabolism
Mannose enters the carbohydrate metabolism stream in two steps:
- First it undergoes phosphorylation to mannose-6-phosphate by hexokinase. Metabolism is the set of Chemical reactions that occur in living Organisms in order to maintain Life. Phosphorylation is the addition of a Phosphate (PO4 group to a Protein molecule or a small molecule Mannose-6-phosphate (M6P is a molecule bound by Lectin in the Immune system. Variation across species Hexokinases have been found in every organism checked ranging from bacteria, Yeast, and Plants to humans and other Vertebrates
- Then, it is converted to fructose-6-phosphate by mannose phosphate isomerase. Fructose 6-phosphate (also known as the Neuberg ester) is Fructose sugar Phosphorylated on carbon 6 (ie Mannose phosphate isomerase is an Enzyme which converts Fructose-6-phosphate and Mannose-6-phosphate.
Mannose is present in numerous glycoconjugates including N-linked glycosylation of proteins. C-mannosylation is also abundant and can be found in collage-like regions. Mannose is a C2 epimer of glucose and displays a ^2C_4 pucker in the solution ring form.
Formation
Mannose can be formed by the oxidation of mannitol. Mannitol or hexan-123456-hexol (C6H8(OH6 is a Polyol that is used as an osmotic Diuretic agent and a
It can also be formed from D-glucose in the Lobry-de Bruyn-van Ekenstein transformation
Etymology
The root of both "mannose" and "manitol" is manna, which the Bible records as the food supplied to the Israelites during their journey through the Sinai Peninsula. The Lobry-de Bruyn-van Ekenstein transformation also known as the Lobry-de Bruyn-van-Alberda-van-Ekenstein transformation is a base catalyzed Aldose Manna (sometimes or archaically spelt mana) ( Hebrew: מָן) is the name of a Food which according to the Bible, was eaten by Etymology According to the Online Etymology Dictionary, the word bible is from Latin biblia, traced from the same word through Medieval Latin and Late Latin Manna is a sweet secretion of several trees and shrubs, such as Fraxinus ornus. Fraxinus ornus ( Manna Ash) is a species of Fraxinus native to southern Europe and southwestern Asia, from Spain
Cranberry juice
D-Mannose, which appears in some fruits including cranberry, has been postulated to prevent the adhesion of bacteria to the epithelium of the urinary tract and Urinary bladder through a mechanism presumed to be competitive in nature with the polysaccharide coating of the cystic epithelium. While no studies have objectively verified this mechanism, anecdotal reports from patients show some improvement in symptoms. [1][2]
Configuration
The fact that D-mannose has the same configuration at its penultimate carbon as D-glyceraldehyde is unsurprising as that is what defines the dextro classification. Glyceraldehyde is a Triose Monosaccharide with Chemical formula C 3 H 6 O 3 However, mannose differs from D-glucose by inversion of the C2 chiral centre. A stereocenter, or stereogenic centre, is any Atom in a Molecule bearing groups such that an interchanging of any two groups leads to a Stereoisomer This apparently simple change leads to the drastically different chemistry of the two hexoses, as it does the remaining six hexoses.
See also
References
External links
Glycosylation is the enzymatic process that links Saccharides to produce glycans, either free or attached to Proteins and Lipids This enzymatic alpha-Mannosidase is an Enzyme involved in the cleavage of the alpha form of Mannose. In Organic chemistry, a hexose is a Monosaccharide with six Carbon atoms having the Chemical formula C6H12O6 The mannose receptor is a calcium-dependent Lectin. It has been researched as a target for Vaccines See also MannoseDictionary
mannose
-noun
- (organic chemistry) A monosaccharide aldohexose found in manna and other legumes
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