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Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
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| Identifiers | ||
| Symbol(s) | MPP6; PALS2; VAM-1; VAM1; p55T | |
| External IDs | OMIM: 606959 MGI: 1927340 HomoloGene: 22976 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 51678 | 56524 |
| Ensembl | ENSG00000105926 | ENSMUSG00000038388 |
| Uniprot | Q9NZW5 | Q3TPA2 |
| Refseq | NM_016447 (mRNA) NP_057531 (protein) |
NM_019939 (mRNA) NP_064323 (protein) |
| Location | Chr 7: 24.58 - 24.69 Mb | Chr 6: 50.04 - 50.13 Mb |
| Pubmed search | [1] | [2] |
Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6), also known as MPP6, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al. , 2001). [supplied by OMIM][1]
References
Further reading
- Kamberov E, Makarova O, Roh M, et al. (2000). "Molecular cloning and characterization of Pals, proteins associated with mLin-7. ". J. Biol. Chem. 275 (15): 11425–31. PMID 10753959.
- Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome. ". J. Biol. Chem. 276 (9): 6177–84. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11110791.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. ". Genome Res. 11 (3): 422–35. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11230166.
- Tseng TC, Marfatia SM, Bryant PJ, et al. (2001). "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain. ". Biochim. Biophys. Acta 1518 (3): 249–59. PMID 11311936.
- Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. ". Cell 107 (4): 451–64. PMID 11719186.
- Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits. ". J. Mol. Biol. 315 (4): 809–18. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11812149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology. ". Science 300 (5620): 767–72. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7. ". Nature 424 (6945): 157–64. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12853948.
- Leonoudakis D, Conti LR, Anderson S, et al. (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2. x)-associated proteins. ". J. Biol. Chem. 279 (21): 22331–46. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15024025.
- Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation. ". Genome Res. 14 (7): 1315–23. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15231747.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. ". Nat. Biotechnol. 23 (1): 94–101. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15592455.
- Scheel AK, Hermann KG, Ohrndorf S, et al. (2006). "Prospective 7 year follow up imaging study comparing radiography, ultrasonography, and magnetic resonance imaging in rheumatoid arthritis finger joints. ". Ann. Rheum. Dis. 65 (5): 595–600. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16192290.
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