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Melan-A
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| Identifiers | ||
| Symbol(s) | MLANA; MART-1; MART1 | |
| External IDs | OMIM: 605513 MGI: 108454 HomoloGene: 4026 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 2315 | 77836 |
| Ensembl | ENSG00000120215 | ENSMUSG00000024806 |
| Uniprot | Q16655 | n/a |
| Refseq | NM_005511 (mRNA) NP_005502 (protein) |
XM_129166 (mRNA) XP_129166 (protein) |
| Location | Chr 9: 5.88 - 5.9 Mb | Chr 19: 29.76 - 29.77 Mb |
| Pubmed search | [1] | [2] |
Melan-A, also known as MLANA, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
References
Further reading
- Coulie PG, Brichard V, Van Pel A, et al. (1994). "A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas. ". J. Exp. Med. 180 (1): 35–42. PMID 8006593.
- Kawakami Y, Eliyahu S, Delgado CH, et al. (1994). "Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor. ". Proc. Natl. Acad. Sci. U. S. A. 91 (9): 3515–9. PMID 8170938.
- Zippelius A, Pittet MJ, Batard P, et al. (2002). "Thymic selection generates a large T cell pool recognizing a self-peptide in humans. ". J. Exp. Med. 195 (4): 485–94. PMID 11854361.
- Moritake H, Sugimoto T, Asada Y, et al. (2002). "Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogene. ". Cancer Genet. Cytogenet. 135 (1): 48–56. PMID 12072203.
- Dutoit V, Rubio-Godoy V, Pittet MJ, et al. (2002). "Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-a peptide multimer(+) CD8(+) T cells in humans. ". J. Exp. Med. 196 (2): 207–16. PMID 12119345.
- Mantovani S, Palermo B, Garbelli S, et al. (2002). "Dominant TCR-alpha requirements for a self antigen recognition in humans. ". J. Immunol. 169 (11): 6253–60. PMID 12444131.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Du J, Miller AJ, Widlund HR, et al. (2003). "MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma. ". Am. J. Pathol. 163 (1): 333–43. PMID 12819038.
- Mandelcorn-Monson RL, Shear NH, Yau E, et al. (2003). "Cytotoxic T lymphocyte reactivity to gp100, MelanA/MART-1, and tyrosinase, in HLA-A2-positive vitiligo patients. ". J. Invest. Dermatol. 121 (3): 550–6. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12925214.
- Ghorab Z, Jorda M, Ganjei P, Nadji M (2004). "Melan A (A103) is expressed in adrenocortical neoplasms but not in renal cell and hepatocellular carcinomas. ". Appl. Immunohistochem. Mol. Morphol. 11 (4): 330–3. PMID 14663359.
- Murer K, Urosevic M, Willers J, et al. (2005). "Expression of Melan-A/MART-1 in primary melanoma cell cultures has prognostic implication in metastatic melanoma patients. ". Melanoma Res. 14 (4): 257–62. PMID 15305155.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Kucher C, Zhang PJ, Pasha T, et al. (2005). "Expression of Melan-A and Ki-67 in desmoplastic melanoma and desmoplastic nevi. ". The American Journal of dermatopathology 26 (6): 452–7. PMID 15618925.
- Hoashi T, Watabe H, Muller J, et al. (2005). "MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes. ". J. Biol. Chem. 280 (14): 14006–16. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15695812.
- Godefroy E, Scotto L, Souleimanian NE, et al. (2006). "Identification of two Melan-A CD4+ T cell epitopes presented by frequently expressed MHC class II alleles. ". Clin. Immunol. 121 (1): 54–62. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16814609.
- Kono M, Dunn IS, Durda PJ, et al. (2007). "Role of the mitogen-activated protein kinase signaling pathway in the regulation of human melanocytic antigen expression. ". Mol. Cancer Res. 4 (10): 779–92. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17050671.
- Bioley G, Jandus C, Tuyaerts S, et al. (2007). "Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers. ". J. Immunol. 177 (10): 6769–79. PMID 17082590.
- Roma AA, Magi-Galluzzi C, Zhou M (2007). "Differential expression of melanocytic markers in myoid, lipomatous, and vascular components of renal angiomyolipomas. ". Arch. Pathol. Lab. Med. 131 (1): 122–5. PMID 17227112.
- Yuan F, Georgiou T, Hillon T, et al. (2007). "Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex. ". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (Pt 9): 758–60. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17768347.
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