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Mannose-6-phosphate receptor binding protein 1
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| Identifiers | ||
| Symbol(s) | M6PRBP1; PP17; MGC11117; MGC2012; TIP47 | |
| External IDs | OMIM: 602702 MGI: 1914155 HomoloGene: 4247 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 10226 | 66905 |
| Ensembl | ENSG00000105355 | ENSMUSG00000024197 |
| Uniprot | O60664 | Q3V4D2 |
| Refseq | NM_005817 (mRNA) NP_005808 (protein) |
XM_972725 (mRNA) XP_977819 (protein) |
| Location | Chr 19: 4.79 - 4.82 Mb | Chr 17: 55.91 - 55.92 Mb |
| Pubmed search | [1] | [2] |
Mannose-6-phosphate receptor binding protein 1, also known as M6PRBP1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. [1]
References
Further reading
- Bohn H, Kraus W, Winckler W (1983). "Purification and characterization of two new soluble placental tissue proteins (PP13 and PP17). ". Oncodev. Biol. Med. 4 (5): 343–50. PMID 6856484.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. ". Gene 138 (1-2): 171–4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. ". Gene 200 (1-2): 149–56. PMID 9373149.
- Díaz E, Pfeffer SR (1998). "TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking. ". Cell 93 (3): 433–43. PMID 9590177.
- Than NG, Sumegi B, Than GN, et al. (1999). "Cloning and sequence analysis of cDNAs encoding human placental tissue protein 17 (PP17) variants. ". Eur. J. Biochem. 258 (2): 752–7. PMID 9874244.
- Than NG, Sumegi B, Than GN, et al. (1999). "Cloning and sequencing of human oncodevelopmental soluble placental tissue protein 17 (PP17): homology with adipophilin and the mouse adipose differentiation-related protein. ". Tumour Biol. 20 (4): 184–92. PMID 10393528.
- Krise JP, Sincock PM, Orsel JG, Pfeffer SR (2000). "Quantitative analysis of TIP47-receptor cytoplasmic domain interactions: implications for endosome-to-trans Golgi network trafficking. ". J. Biol. Chem. 275 (33): 25188–93. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10829017.
- Orsel JG, Sincock PM, Krise JP, Pfeffer SR (2000). "Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein. ". Proc. Natl. Acad. Sci. U. S. A. 97 (16): 9047–51. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10908666.
- Barbero P, Buell E, Zulley S, Pfeffer SR (2001). "TIP47 is not a component of lipid droplets. ". J. Biol. Chem. 276 (26): 24348–51. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11313361.
- Carroll KS, Hanna J, Simon I, et al. (2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47. ". Science 292 (5520): 1373–6. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11359012.
- Hanna J, Carroll K, Pfeffer SR (2002). "Identification of residues in TIP47 essential for Rab9 binding. ". Proc. Natl. Acad. Sci. U. S. A. 99 (11): 7450–4. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12032303.
- Miura S, Gan JW, Brzostowski J, et al. (2002). "Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium. ". J. Biol. Chem. 277 (35): 32253–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12077142.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Sincock PM, Ganley IG, Krise JP, et al. (2003). "Self-assembly is important for TIP47 function in mannose 6-phosphate receptor transport. ". Traffic 4 (1): 18–25. PMID 12535272.
- Than NG, Sumegi B, Bellyei S, et al. (2003). "Lipid droplet and milk lipid globule membrane associated placental protein 17b (PP17b) is involved in apoptotic and differentiation processes of human epithelial cervical carcinoma cells. ". Eur. J. Biochem. 270 (6): 1176–88. PMID 12631276.
- Nair P, Schaub BE, Rohrer J (2003). "Characterization of the endosomal sorting signal of the cation-dependent mannose 6-phosphate receptor. ". J. Biol. Chem. 278 (27): 24753–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12697764.
- Blot G, Janvier K, Le Panse S, et al. (2003). "Targeting of the human immunodeficiency virus type 1 envelope to the trans-Golgi network through binding to TIP47 is required for env incorporation into virions and infectivity. ". J. Virol. 77 (12): 6931–45. PMID 12768012.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway. ". Genome Res. 14 (7): 1324–32. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15231748.
- Ganley IG, Carroll K, Bittova L, Pfeffer S (2005). "Rab9 GTPase regulates late endosome size and requires effector interaction for its stability. ". Mol. Biol. Cell 15 (12): 5420–30. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15456905.
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