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Leukocyte cell derived chemotaxin 1
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| Identifiers | ||
| Symbol(s) | LECT1; BRICD3; CHM-I; CHM1 | |
| External IDs | OMIM: 605147 MGI: 1341171 HomoloGene: 5095 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 11061 | 16840 |
| Ensembl | ENSG00000136110 | ENSMUSG00000022025 |
| Uniprot | O75829 | Q80UX1 |
| Refseq | NM_001011705 (mRNA) NP_001011705 (protein) |
NM_010701 (mRNA) NP_034831 (protein) |
| Location | Chr 13: 52.18 - 52.21 Mb | Chr 14: 78.37 - 78.4 Mb |
| Pubmed search | [1] | [2] |
Leukocyte cell derived chemotaxin 1, also known as LECT1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [1]
References
Further reading
- Hiraki Y, Shukunami C (2000). "Chondromodulin-I as a novel cartilage-specific growth-modulating factor. ". Pediatr. Nephrol. 14 (7): 602-5. PMID 10912526.
- Shukunami C, Hiraki Y (1998). "Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro. ". Biochem. Biophys. Res. Commun. 249 (3): 885-90. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9731231.
- Hiraki Y, Mitsui K, Endo N, et al. (1999). "Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells. ". Eur. J. Biochem. 260 (3): 869-78. PMID 10103018.
- Hayami T, Shukunami C, Mitsui K, et al. (2000). "Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo. ". FEBS Lett. 458 (3): 436-40. PMID 10570955.
- Yanagihara I, Yamagata M, Sakai N, et al. (2000). "Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells. ". J. Bone Miner. Res. 15 (3): 421-9. PMID 10750556.
- Azizan A, Holaday N, Neame PJ (2001). "Post-translational processing of bovine chondromodulin-I. ". J. Biol. Chem. 276 (26): 23632-8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11323410.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Aoyama T, Okamoto T, Nagayama S, et al. (2004). "Expression of the chondromodulin-I gene in chondrosarcomas. ". Cancer Lett. 204 (1): 61-8. PMID 14744535.
- Aoyama T, Okamoto T, Nagayama S, et al. (2004). "Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3. ". J. Biol. Chem. 279 (27): 28789-97. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15107420.
- Yoshioka M, Yuasa S, Matsumura K, et al. (2006). "Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. ". Nat. Med. 12 (10): 1151-9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16980969.
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