| Kuru Classification and external resources | |
| ICD-10 | A81.8 |
|---|---|
| ICD-9 | 046.0 |
| DiseasesDB | 31861 |
| MedlinePlus | 001379 |
| eMedicine | med/1248 |
| MeSH | D007729 |
Kuru is a disease which affects the brain. The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify Diseases The International Statistical Classification of Diseases and Related Health Problems 10th Revision ( ICD -10) is a coding of diseases and signs symptoms abnormal findings A00-A79 - Bacterial infections and other intestinal infectious diseases and STDs (A00-A09 Intestinal Infectious diseases ( The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify Diseases The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. The Diseases Database is a free Website that provides information about the relationships between medical conditions Symptoms, and Medications. MedlinePlus, with the MedlinePlus Medical Encyclopedia, is a website network containing Health information from the world's largest medical Library eMedicine is an online clinical medical knowledge base that was founded in 1996 by Scott Plantz and Richard Lavely two medical doctors Medical Subject Headings ( MeSH) is a huge Controlled vocabulary (or metadata system for the purpose of indexing journal articles and books The brain is the center of the Nervous system in animals All Vertebrates and the majority of Invertebrates have a brain It was endemic among the Fore tribe of Papua New Guinea and was universally fatal. Endemism is the Ecological state of being unique to a place Endemic species are not naturally found elsewhere The Fore live in the Okapa District of the Eastern Highlands Province, Papua New Guinea. Papua New Guinea (or ˈpæpjuːə in Tok Pisin: Papua Niugini) officially the Independent State of Papua New Guinea, is a country in Oceania It is characterized by headaches, joint pains and shaking of the limbs. It is believed to be caused by prions and is related to Creutzfeldt-Jakob disease. A prion (ˈpriːɒn is thought to be an infectious agent that according to current scientific consensus is comprised entirely of a propagated, mis-folded Creutzfeldt-Jakob disease ( CJD) is a very rare and incurable degenerative neurological disorder ( Brain Disease) that is ultimately [1] It is best known for the epidemic that occurred in Papua New Guinea in the middle of the twentieth century. In Epidemiology, an epidemic (from Greek epi- upon + demos people is a classification of a disease that appears as new cases in a [2] The word kuru means "trembling with fear" in the language of the Fore people, those most commonly afflicted with the disease. [3] It is also known as the laughing sickness due to the pathologic bursts of laughter the patient displays when afflicted with the disease. [4] Trembling is present in almost all patients with transmissible spongiform encephalopathy. Transmissible spongiform encephalopathies' ( TSEs, also known as prion diseases) are a group of progressive conditions that affect the Brain and
History
Kuru was first noted in native people of New Guinea in 1957–1959. It was in the late 1950s that the full extent of the disease was realized, after it had reached large infection rates in the South Fore of the Okapa Subdistrict, though the agent was unknown. [5]
The disease was researched by Daniel Carleton Gajdusek who was awarded (with Baruch S. Blumberg) the Nobel Prize in Physiology or Medicine in 1976 for his work on it. Daniel Carleton Gajdusek (born September 9 1923 in Yonkers, New York, USA is an American Physician and medical researcher Baruch Samuel Blumberg (born July 28, 1925) is an American scientist and recipient of the 1976 The Nobel Prize in Physiology or Medicine (Nobelpriset i fysiologi eller medicin is awarded once a year by the Swedish Karolinska Institute.
Transmission
It is believed by some that the disease spread easily in the Fore people due to their cannibalistic funeral practices. Cannibalism (from Spanish es ''caníbal'' in connection with cannibalism among the Antillean Caribs, also called anthropophagy (from Greek ἄνθρωπος The dysmorphism evident in the infection rates -- it was more prevalent in women and children -- is because while the men of the village ate the flesh of the deceased, the women and children ate the brain, where the disease particles are concentrated. There is also the strong possibility that it was passed on to women and children more easily because they took on the task of cleaning relatives after death. [3]With elimination of these practices, Kuru disappeared among the South Fore within a generation.
References
- ^ Collinge J, Whitfield J, McKintosh E, et al (Jun 2006). "Kuru in the 21st century—an acquired human prion disease with very long incubation periods". Lancet 367 (9528): 2068–74. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16798390.
- ^ Kuru Information Page: National Institute of Neurological Disorders and Stroke (NINDS)
- ^ a b eMedicine - Kuru : Article by Paul A Janson
- ^ Purdey, Mark. "Explanation of Kuru Disease"
- ^ Kuru: The Dynamics of a Prion Disease
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