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KEGG (Kyoto Encyclopedia of Genes and Genomes) is a collection of online databases dealing with genomes, enzymatic pathways, and biological chemicals. An online database is a Database accessible via a network now generally the internet In classical genetics the genome of a Diploid Organism including Eukarya refers to a full set of chromosomes or genes in a Gamete, thereby In Biochemistry, a metabolic pathway is a series of chemical reactions occurring within a cell. The PATHWAY database records networks of molecular interactions in the cells, and variants of them specific to particular organisms. Interactome is defined as the whole set of molecular interactions in cells

Contents

Introduction

The KEGG, the Kyoto Encyclopedia of Genes and Genomes, was initiated by the Japanese human genome programme in 1995[1]. (IPA /kʲoːto / is a city in the central part of the island of Honshū, Japan. According to the developers they consider KEGG to be a "computer representation" of the biological system[2]. The KEGG database can be utilized for modeling and simulation, browsing and retrieval of data. It is a part of the systems biology approach.

KEGG maintains five main databases

Databases

KEGG connects known information on molecular interaction networks, such as pathways and complexes (this is the Pathway Database), information about genes and proteins generated by genome projects (including the gene database) and information about biochemical compounds and reactions (including compound and reaction databases). Interactome is defined as the whole set of molecular interactions in cells Proteins are large Organic compounds made of Amino acids arranged in a linear chain and joined together by Peptide bonds between the Carboxyl These databases are different networks, known as the protein network, the gene universe and the chemical universe respectively. There are efforts in progress to add to the knowledge of KEGG, including information regarding ortholog clusters in the KO (KEGG Orthology) database. In Evolutionary biology, homology has come to mean any similarity between characters that is due to their shared ancestry. [3]

KEGG Pathways:

Ligand Database:

See also

Comparative Toxicogenomics Database - CTD integrates KEGG pathways with toxicogenomic and disease data

References

  1. ^ [doi:10. Metabolism is the set of Chemical reactions that occur in living Organisms in order to maintain Life. A disease is an abnormal condition of an organism that impairs bodily functions and can be deadly Drug development or preclinical development is defined in many pharmaceutical companies as the process of taking a new chemical lead through the stages necessary to allow it The term glycan refers to a Polysaccharide or Oligosaccharide. The Comparative Toxicogenomics Database (CTD is a public website and research tool that curates scientific data describing relationships between chemicals genes and human diseases 1016/S0168-9525(97)01223-7 Minoru Kanehisa, A database for post-genome analysis, Trends in Genetics Volume 13, Issue 9, September 1997, Pages 375-376]
  2. ^ From genomics to chemical genomics:New development in KEGG. PubMed Link
  3. ^ Kanehisa M, Goto S, Kawashima S, Okuno Y, Hattori M., The KEGG resource for deciphering the genome, Nucleic Acids Res. 2004 Jan 1;32(Database issue):D277-80.

External links

MetaBase is a user contributed Database of Biological databases, listing all the biological databases currently available on the Internet
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