Jet lag, also jetlag or jet-lag, is a physiological condition which is a consequence of alterations to circadian rhythms; it is classified as one of the circadian rhythm sleep disorders. The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify Diseases The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. Medical Subject Headings ( MeSH) is a huge Controlled vocabulary (or metadata system for the purpose of indexing journal articles and books Physiology (from Greek grc φύσις physis, "nature origin" and grc -λογία -logia) is the study of the mechanical physical Circadian rhythm sleep disorders are a family of Sleep disorders affecting among other things the timing of sleep Such disturbances result from shift work, daylight saving time, chronic congenital disorders, or as the name implies, rapid transmeridian travel as on a jet plane. Daylight saving time ( DST A jet aircraft is an Aircraft propelled by Jet engines Jet aircraft fly much faster than Propeller -powered aircraft and at higher altitudes -- as high as They are known as desynchronosis, dysrhythmia, dyschrony, jet lag, or jet syndrome. The condition is generally believed to be the result of disruption of the "light/dark" cycle that entrains the body's circadian rhythms.

The condition of jet lag may last many days, and medical experts have deemed that a recovery rate of "one day per time zone" is a fair guideline. A medical guideline (also called a clinical guideline, clinical protocol or clinical practice guideline) is a document with the aim of guiding decisions Good sleep hygiene promotes rapid recovery from jet lag: in fact sleep, relaxation, moderate exercise, and sensible diet seem to be the simplest recovery methods. Sleep hygiene can be defined as "all behavioural and environmental factors that precede sleep and may interfere with sleep

However, since the experience of jet lag varies among individuals, it is difficult to assess the efficacy of any single remedy. Age may also be a factor on the severity of jet lag, as younger people will suffer worse jet lag than older people would^[1].

Women of reproductive age are more susceptible to jet lag than are men;^[2] this is in part because estrogen is often vulnerable to jet lag-like conditions^[3]. Estrogens (US otherwise oestrogens or œstrogens) are a group of Steroid compounds named for their importance in the Estrous cycle,

Most chemical and herbal remedies, including the hormone melatonin, have not been tested nor approved by official agencies such as the U. Melatonin is a naturally occurring Hormone found in most animals including humans and some other living organisms including Algae. S. Food and Drug Administration. Few studies have tested the use of melatonin for jet lag and they've given mixed results, likely because the timing of administration need be precise and individualized.

A recent study in hamsters showed that sildenafil (also known commercially as Viagra) aided in a 50% faster recovery from shifts comparable to eastward travel experienced by humans and was effective starting at low doses. Hamsters are Rodents belonging to the Subfamily Cricetinae. The subfamily contains about 18 Species, classified in six or seven genera Sildenafil citrate, sold as Viagra, Revatio and under various other trade names is a drug used to treat Erectile dysfunction (male impotence Sildenafil citrate, sold as Viagra, Revatio and under various other trade names is a drug used to treat Erectile dysfunction (male impotence ^[4] However, this use has not been tested in humans and is considered an off-label use by the drug's manufacturers.

Cause

When traveling across a number of time zones, the body clock will be out of sync with the destination time, as it experiences daylight and darkness contrary to the rhythms to which it has grown accustomed: the body's natural pattern is upset, as the rhythms that dictate times for eating, sleeping, hormone regulation and body temperature no longer correspond to the environment nor to each other in some cases. "Jet lag" describes the physical symptoms that occur because the body cannot immediately realign these rhythms. The speed at which the body readjusts itself to new daylight/darkness hours is individually determined. Thus, while it may take several days for some people to readjust to a new time zone, others seem to experience little disruption to their body's natural patterns. It is, however, not common to get jet lag from a crossing of only one or two time zones.

Symptoms

The symptoms of jet lag can be quite varied, though on the whole, an individual may experience the following^[5]:

• Loss of appetite
• Nausea and/or upset stomach
• Headaches and/or sinus irritation
• Fatigue
• Disorientation and/or grogginess
• Insomnia and/or highly irregular sleep patterns
• Irritability, irrationality
• Mild depression
• Dehydration (possibly because of dry air in the 'plane, and thus as likely on long north/south flights)

Frequent changes of time zone, working long hours, or rotating shifts causes a loss of productivity, alertness, and safety costing an estimated $70 billion per year. Nausea ( Latin: Nausea, Greek:, " Sea-sickness " also called wamble) is the sensation of unease and discomfort Paranasal sinuses are air-filled spaces communicating with the nasal cavity within the bones of the Skull and face Irritation or exacerbation, in Biology and Physiology, is a state of Inflammation or painful reaction to Allergy or cell-lining damage Orientation is a function of the Mind involving awareness of three dimensions Time, Place and Person. Insomnia is a symptom of a sleeping disorder characterized by persistent difficulty falling asleep or staying asleep despite the opportunity Irritability is an excessive response to stimuli. Irritability takes many forms from the Contraction of a Unicellular organism when touched to complex In the fields of Psychology and Psychiatry, the terms depression or depressed refer to both expected and pathologically chronic or severe Dehydration ( hypohydration) is the removal of Water ( hydro in ancient Greek) from an object ^[6]

The condition is not linked to the length of flight, but to the transmeridian (i. e. , east-west) distance traveled. Hence, a ten-hour flight between Frankfurt and Johannesburg (going south, staying roughly on the same meridian) is much less inducive of jet lag than a five-hour flight between New York and Los Angeles or vice versa. Johannesburg ( Pronounced /jō-hān'ĭs-bûrg'/ is the largest city in South Africa. New York ( is a state in the Mid-Atlantic and Northeastern regions of the United States and is the nation's third most populous Los Angeles (lɑˈsændʒələs los ˈaŋxeles in Spanish) is the largest City in the state of California and the American West Also, the International Date Line should not be confused as contributing to jet lag, as the maximum possible disruption is plus or minus 12 hours. If the time difference between two locations is greater than 12 hours, subtract that number from 24. (For example, a 20 hour time difference equals 4 hours of jet lag). Layovers can complicate this simple arithmetic, however. In transportation a layover or lay over is some form of a break between trips of parts of a single trip In mass transit A layover for a mass transit

Jet lag can be especially difficult near the north and south poles, where there are extreme periods of daylight or darkness, depending on the time of year, which often causes insomnia or hypersomnia. The North Pole, also known as the Geographic North Pole or Terrestrial North Pole, is subject to the caveats explained below defined as the point in the northern The South Pole, also known as the Geographic South Pole or Terrestrial South Pole, is the southernmost point on the surface of the Earth. Insomnia is a symptom of a sleeping disorder characterized by persistent difficulty falling asleep or staying asleep despite the opportunity Hypersomnia is excessive amount of sleepiness. Description Hypersomnia is characterized by reoccuring episodes of Excessive daytime sleepiness

Direction of Travel

There seems to be some evidence that traveling west to east is the more disruptive. This may be because flights to the east run counter to the circadian rhythm. ^[7] Most people have a circadian period which is a bit longer than 24 hours, making it easier to stay up later than to get up earlier.

It may also be that flights to the east are more likely to require people to stay awake more than one full night in order to adjust to the local time zone. For example, comparing a typical schedule for a traveler flying to the East vs a traveler flying to the West:

• Westward from London to Los Angeles, VIA BA0279, Jan 29, 2008. Time zone difference 8 hours.

Westward	Biological clock	Los Angeles local time
Departure	JAN 29 - 10:05	JAN 29 - 02:05
Arrival	JAN 29 - 21:10	JAN 29 - 13:10
Bedtime	JAN 30 - 06:00	JAN 29 - 22:00

• Eastward from Los Angeles to London, VIA BA0278, Jan 29, 2008.

Eastward	Biological clock	London local time
Departure	JAN 29 - 15:59	JAN 29 - 23:59
Arrival	JAN 30 - 02:05	JAN 30 - 10:05
Bedtime	JAN 30 - 14:00	JAN 30 - 22:00

The first scenario is equivalent to staying up all night and going to bed at 6am the next day — 8 hours later than usual. But the second scenario (eastward) is equivalent to staying up all night and going to bed at 2pm the next day — 16 hours after the time one would otherwise have gone to bed.

See also

• Chronobiology
• Light therapy

References