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Integrin, alpha 8
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| Identifiers | ||
| Symbol(s) | ITGA8; | |
| External IDs | OMIM: 604063 MGI: 109442 HomoloGene: 37396 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 8516 | 241226 |
| Ensembl | ENSG00000077943 | ENSMUSG00000026768 |
| Uniprot | P53708 | n/a |
| Refseq | NM_003638 (mRNA) NP_003629 (protein) |
NM_001001309 (mRNA) NP_001001309 (protein) |
| Location | Chr 10: 15.6 - 15.8 Mb | Chr 2: 12.02 - 12.22 Mb |
| Pubmed search | [1] | [2] |
Integrin, alpha 8, also known as ITGA8, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
References
Further reading
- Schnapp LM, Hatch N, Ramos DM, et al. (1995). "The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. ". J. Biol. Chem. 270 (39): 23196–202. PMID 7559467.
- Schnapp LM, Breuss JM, Ramos DM, et al. (1995). "Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells. ". J. Cell. Sci. 108 ( Pt 2): 537–44. PMID 7768999.
- Denda S, Müller U, Crossin KL, et al. (1998). "Utilization of a soluble integrin-alkaline phosphatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C. ". Biochemistry 37 (16): 5464–74. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9548928.
- Hartner A, Schöcklmann H, Pröls F, et al. (1999). "Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis. ". Kidney Int. 56 (4): 1468–80. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10504498.
- Littlewood Evans A, Müller U (2000). "Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1. ". Nat. Genet. 24 (4): 424–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10742111.
- Brandenberger R, Schmidt A, Linton J, et al. (2001). "Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney. ". J. Cell Biol. 154 (2): 447–58. PMID 11470831.
- Ljubimov AV, Saghizadeh M, Pytela R, et al. (2001). "Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. ". J. Histochem. Cytochem. 49 (11): 1341–50. PMID 11668187.
- Valerius MT, Patterson LT, Feng Y, Potter SS (2002). "Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney. ". Proc. Natl. Acad. Sci. U. S. A. 99 (12): 8090–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12060755.
- Lu M, Munger JS, Steadele M, et al. (2003). "Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1. ". J. Cell. Sci. 115 (Pt 23): 4641–8. PMID 12415008.
- Bieritz B, Spessotto P, Colombatti A, et al. (2004). "Role of alpha8 integrin in mesangial cell adhesion, migration, and proliferation. ". Kidney Int. 64 (1): 119–27. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12787402.
- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10. ". Nature 429 (6990): 375–81. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15164054.
- Ekwa-Ekoka C, Diaz GA, Carlson C, et al. (2005). "Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8). ". Matrix Biol. 23 (7): 487–96. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15579315.
- Scherberich A, Tucker RP, Degen M, et al. (2005). "Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro. ". Oncogene 24 (9): 1525–32. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15592496.
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