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Insulin receptor-related receptor
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| Identifiers | ||
| Symbol(s) | INSRR; IRR | |
| External IDs | OMIM: 147671 MGI: 1346037 HomoloGene: 56539 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 3645 | 23920 |
| Ensembl | ENSG00000027644 | ENSMUSG00000005640 |
| Uniprot | P14616 | Q3UQC8 |
| Refseq | NM_014215 (mRNA) NP_055030 (protein) |
NM_011832 (mRNA) NP_035962 (protein) |
| Location | Chr 1: 155.08 - 155.1 Mb | Chr 3: 87.88 - 87.9 Mb |
| Pubmed search | [1] | [2] |
Insulin receptor-related receptor, also known as INSRR, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
References
Further reading
- Zhang B, Roth RA (1992). "The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities. ". J. Biol. Chem. 267 (26): 18320–8. PMID 1326521.
- Shier P, Willard HF, Watt VM (1991). "Localization of the insulin receptor-related receptor gene to human chromosome 1. ". Cytogenet. Cell Genet. 54 (1-2): 80–1. PMID 2249481.
- Shier P, Watt VM (1989). "Primary structure of a putative receptor for a ligand of the insulin family. ". J. Biol. Chem. 264 (25): 14605–8. PMID 2768234.
- Mathi SK, Chan J, Watt VM (1995). "Insulin receptor-related receptor messenger ribonucleic acid: quantitative distribution and localization to subpopulations of epithelial cells in stomach and kidney. ". Endocrinology 136 (9): 4125–32. PMID 7649121.
- Kovacina KS, Roth RA (1995). "Characterization of the endogenous insulin receptor-related receptor in neuroblastomas. ". J. Biol. Chem. 270 (4): 1881–7. PMID 7829525.
- Jui HY, Accili D, Taylor SI (1996). "Characterization of a hybrid receptor formed by dimerization of the insulin receptor-related receptor (IRR) with the insulin receptor (IR): coexpression of cDNAs encoding human IRR and human IR in NIH-3T3 cells. ". Biochemistry 35 (45): 14326–30. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 8916919.
- Hänze J, Berthold A, Klammt J, et al. (1999). "Cloning and sequencing of the complete cDNA encoding the human insulin receptor related receptor. ". Horm. Metab. Res. 31 (2-3): 77–9. PMID 10226785.
- Xu P, Jacobs AR, Taylor SI (1999). "Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins. ". J. Biol. Chem. 274 (21): 15262–70. PMID 10329736.
- Elmlinger MW, Rauschnabel U, Koscielniak E, et al. (1999). "Correlation of type I insulin-like growth factor receptor (IGF-I-R) and insulin receptor-related receptor (IRR) messenger RNA levels in tumor cell lines from pediatric tumors of neuronal origin. ". Regul. Pept. 84 (1-3): 37–42. PMID 10535406.
- Whitmore TE, Maurer MF, Day HL, et al. (2000). "The assignment of the human insulin receptor-related receptor gene (INSRR) to chromosome 1q21-->q23 by the use of radiation hybrid mapping. ". Cytogenet. Cell Genet. 87 (1-2): 93–4. PMID 10640820.
- Weber A, Huesken C, Bergmann E, et al. (2004). "Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas. ". Clin. Cancer Res. 9 (15): 5683–92. PMID 14654552.
- Klammt J, Garten A, Barnikol-Oettler A, et al. (2005). "Comparative analysis of the signaling capabilities of the insulin receptor-related receptor. ". Biochem. Biophys. Res. Commun. 327 (2): 557–64. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15629149.
- Dissen GA, Garcia-Rudaz C, Tapia V, et al. (2006). "Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary. ". Endocrinology 147 (1): 155–65. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16195402.
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