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Human skin color can range from almost black to nearly colorless (appearing pinkish white due to the blood in the skin) in different people. Blood is a specialized Bodily fluid that delivers necessary substances to the body's cells such as nutrients and oxygen—and transports Waste products The skin is the outer covering of living tissue of an animal (or plant Human beings, humans or man (Origin 1590–1600 L homō man OL hemō the earthly one (see Humus Skin color is determined by the amount and type of melanin, the pigment in the skin which is largely inherited than environmental. Melanin is a class of compounds found in the Plant, Animal and Protista kingdoms, where it serves predominantly as a Pigment. For the drug referred to as "pigment" see Black tar heroin. As a general pattern people with ancestors from tropical regions (hence greater sunlight exposure) have darker skin than people with ancestors from subtropical regions, this is far from a hard and fast rule however. An ancestor is a Parent or ( recursively) the parent of an ancestor (i The Tropics are centered on the Equator and limited in Latitude by the Tropic of Cancer in the northern hemisphere at approximately 23°26' (23 The subtropics are the zones of the Earth immediately north and south of the tropic zone which is bounded by the Tropic of Cancer and the Tropic of [1][2]

Contents

Melanin and genes

Main article: Melanin

Melanin comes in two types: pheomelanin (red) and eumelanin (dark brown to nearly black). Melanin is a class of compounds found in the Plant, Animal and Protista kingdoms, where it serves predominantly as a Pigment. Melanin is a class of compounds found in the Plant, Animal and Protista kingdoms, where it serves predominantly as a Pigment. Melanin is a class of compounds found in the Plant, Animal and Protista kingdoms, where it serves predominantly as a Pigment. Both amount and type are determined by four to six genes which operate under incomplete dominance. History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance One copy of each of those genes is inherited from each parent. Each gene comes in several alleles, resulting in a great variety of different skin tones. An allele (ˈæliːl (UK /əˈliːl/ (US (from the Greek αλληλος allelos, meaning each other) is one member of a pair or series of different forms

Albinistic Child with mother in Tanzania
Albinistic Child with mother in Tanzania

The evolution of the different skin tones is thought to have occurred as follows: the haired ancestors of humans, like modern great apes, had light skin under their hair. Albinism (from Latin albus, "white" see extended etymology) is a form of hypopigmentary Congenital disorder, Tanzania ˌtænzəˈniːə officially the United Republic of Tanzania (Jamhuri ya Muungano wa Tanzania is a country in East Africa bordered by Kenya eVolution is the third Album by eLDee, it was due to be released in 2008 Once they encountered baldness, they evolved dark skin, needed to prevent low folate levels since they lived in sun-rich Africa. Baldness involves the state of lacking hair where it often grows especially on the head Folic acid (also known as Vitamin M and Folacin) and Folate (the Anionic form are forms of the water-soluble Vitamin B9 (The skin cancer connection is probably of secondary importance, since skin cancer usually kills only after the reproductive age and therefore does not exert much evolutionary pressure. ) When humans migrated to less sun-intensive regions in the north, low vitamin D3 levels became a problem and light skin color re-emerged.

The Inuit and Yupik are special cases: even though they live in an extremely sun-poor environment, they have retained their relatively dark skin. Inuit (plural the singular Inuk, means "man" or "person" is a general term for a group of culturally similar Indigenous peoples inhabiting The Yupik or in the Central Alaskan Yup'ik language, Yup'ik, are a group of indigenous or aboriginal peoples of western southwestern and southcentral This can be explained by the fact that their traditional animal-based diet provides plenty of vitamin D.

Health related effects

Dark skin protects against ultraviolet light; this light causes mutations in skin cells, which in turn cause skin cancers. Ultraviolet ( UV) light is Electromagnetic radiation with a Wavelength shorter than that of Visible light, but longer than X-rays In biology mutations are changes to the Nucleotide sequence of the Genetic material of an organism Skin cancer is a Malignant growth on the Skin which can have many causes Light-skinned persons have about a tenfold greater risk of dying from skin cancer under equal sunlight exposure, with redheads having the greatest risk. Sunlight, in the broad sense is the total spectrum of the Electromagnetic radiation given off by the Sun. This article is about people with red hair also sometimes called redheads Furthermore, dark skin prevents radiation of UV-A rays from destroying the essential folic acid, derived from B vitamins. Radiation, as in Physics, is Energy in the form of waves or moving Subatomic particles emitted by an atom or other body as it changes from a higher energy A Black light or UV Light is a lamp emitting Electromagnetic radiation that is almost exclusively in the soft near ultraviolet range and emits Folic acid (also known as Vitamin M and Folacin) and Folate (the Anionic form are forms of the water-soluble Vitamin B9 The B vitamins are eight water-soluble Vitamins that play important roles in cell Metabolism. Folic acid (or folate) is needed for the synthesis of DNA in dividing cells and folate deficiency in pregnant women are associated with birth defects. Deoxyribonucleic acid ( DNA) is a Nucleic acid that contains the genetic instructions used in the development and functioning of all known Cell division is a process by which a cell, called the parent cell divides into two or more cells called daughter cells.

While dark skin better preserves vitamin B, it can also lead to vitamin D deficiency which in turn can cause fatal cancers affecting the colon, lung and prostate. Vitamin D is a group of fat-soluble Prohormones, the two major forms of which are vitamin D2 (or Ergocalciferol) and vitamin D3 (or Dark-skinned people are also at higher risk for rickets, cardiovascular disease, diabetes and multiple sclerosis. Rickets is a softening of the bones in children potentially leading to fractures and deformity Cardiovascular disease or cardiovascular diseases refers to the class of diseases that involve the Heart or Blood vessels ( arteries and Diabetes mellitus (ˌdaɪəˈbiːtiːz or /ˌdaɪəˈbiːtəs/ /məˈlaɪtəs/ or /ˈmɛlətəs/ often referred to simply as diabetes ( Ancient Greek: grc Multiple sclerosis (abbreviated MS also known as disseminated sclerosis or encephalomyelitis disseminata) is an autoimmune condition in which the [3]. To address this issue, some countries have programs to ensure fortification of milk with vitamin D. Fortifications are Military Constructions and Buildings designed for defense in Warfare Humans have constructed defensive works for Vitamin D is a group of fat-soluble Prohormones, the two major forms of which are vitamin D2 (or Ergocalciferol) and vitamin D3 (or

The advantage of light skin is that it allows more sun absorption, leading to increased production of vitamin D3, necessary for calcium absorption and bone growth. Calcium (ˈkælsiəm is the Chemical element with the symbol Ca and Atomic number 20 Ossification is the process of Bone formation in which connective tissues such as Cartilage are turned to bone or bone-like tissue The lighter skin of women may result from the higher calcium needs of women during pregnancy and lactation. Pregnancy ( Latin graviditas) is the carrying of one or more offspring known as a Fetus or Embryo, inside the Uterus of a Female Lactation describes the secretion of Milk from the Mammary glands the process of providing that milk to the young and the period of time that a Mother

Albinism is a condition characterized by the absence of melanin, resulting in very light skin and hair; it is caused by a particular recessive gene. Albinism (from Latin albus, "white" see extended etymology) is a form of hypopigmentary Congenital disorder,

Cultural effects

Historically, differences in skin tone have often resulted in racism and color terminology for race. List of racism-related topics|Racism by country Racism, by its simplest definition is the belief that race is the primary determinant of human traits and capacities and that In most societies and by some anthropologists color terminology was used to label races sometimes in addition to a non-color term for the same race.

Research on skin tone variability

The tone of human skin can vary from a dark brown to nearly a colorless pigmentation, which appears pale pink due to the blood in the skin. Europeans have lighter skin, hair, and eyes than any other group on Earth. In attempting to discover the mechanisms that have generated such a wide variation in human skin tone, Jablonski & Chaplin (2000) discovered that there is a high correlation between the tone of human skin of indigenous peoples and the average annual ultraviolet (UV) radiation available for skin exposure where the indigenous peoples live. Ultraviolet ( UV) light is Electromagnetic radiation with a Wavelength shorter than that of Visible light, but longer than X-rays Accordingly, Jablonski and Chaplin plotted the skin tone (W) of indigenous peoples who have stayed in the same geographical area for the last 500 years versus the annual UV available for skin exposure (AUV) for over 200 indigenous persons and found that skin tone lightness W is related to the annual UV available for skin exposure AUV according to[4]

W = 70 - \frac{AUV}{10}

where the skin tone lightness W is measured as the percentage of light reflected from the upper inner arm at which location on humans there should be minimal tanning of human skin due to personal exposure to the sun; a lighter skinned human would reflect more light and would have a higher W number. Judging from the above linear fit to the empirical data, the theoretical lightness maximum of human skin would reflect only 70 per cent of incident light for a hypothetical indigenous human-like population that lived where there was zero annual UV available for skin exposure (AUV = 0 in the above formula). Jablonski and Chaplin evaluated average annual UV available for skin exposure AUV from satellite measurements that took into consideration the measured daily variation in the thickness of the ozone layer that blocked UV hitting the Earth, measured daily variation in opacity of cloud cover, and daily change in angle at which the sunlight containing UV radiation strikes the Earth and passes through different thicknesses of Earth's atmosphere at different latitudes for each of the different human indigenous peoples' home areas from 1979 to 1992.

Jablonski and Chaplin proposed an explanation for the observed variation of untanned human skin with annual UV exposure. By Jablonski and Chaplin's explanation, there are two competing forces affecting human skin tone:

  1. the melanin that produces the darker tones of human skin serves as a light filter to protect against too much UV light getting under the human skin where too much UV causes sunburn and disrupts the synthesis of precursors necessary to make human DNA; versus
  2. humans need at least a minimum threshold of UV light to get deep under human skin to produce vitamin D, which is essential for building and maintaining the bones of the human skeleton. Natural selection is the process by which favorable Heritable traits become more common in successive Generations of a Population of Vitamin D is a group of fat-soluble Prohormones, the two major forms of which are vitamin D2 (or Ergocalciferol) and vitamin D3 (or Bones are rigid organs that form part of the Endoskeleton of Vertebrates They function to move support and protect the various organs of the body produce The human skeleton consists of both fused and individual Bones supported and supplemented by Ligaments Tendons Muscles and Cartilage

Jablonski and Chaplin note that when human indigenous peoples have migrated, they have carried with them a sufficient gene pool so that within a thousand years, the skin of their descendants living today has turned dark or turned light to adapt to fit the formula given above—with the notable exception of dark-skinned peoples moving north, such as to populate the seacoast of Greenland, to live where they have a year-round supply of food rich in vitamin D, such as fish, so that there was no necessity for their skin to lighten to let enough UV under their skin to synthesize the vitamin D that humans need for healthy bones.

In considering the tone of human skin in the long span of human evolution, Jablonski and Chaplin note that there is no empirical evidence to suggest that the human ancestors six million years ago had a skin tone different from the skin tone of today's chimpanzees—namely light-skinned under black hair. Human evolution, or anthropogenesis, is the part of biological Evolution concerning the emergence of Homo sapiens as a distinct Species Chimpanzee (often shortened to chimp) is the common name for the two extant Species of Apes in the Genus Pan. But as humans evolved to lose their body hair a parallel evolution permitted human populations to turn their base skin tone dark or light over a period of less than a thousand years to adjust to the competing demands of 1) increasing eumelanin to protect from UV that was too intense and 2) reducing eumelanin so that enough UV would penetrate to synthesize enough vitamin D. Androgenic hair, colloquially Body hair, is the Terminal hair on the Human body developed during and after Puberty. By this explanation, in the time that humans lived only in Africa, humans had dark skin to the extent that they lived for extended periods of time where the sunlight is intense. In Paleoanthropology, the recent African origin of modern humans is one of two hypotheses of the origin of anatomically modern humans Homo sapiens sapiens As some humans migrated north, over time they developed light skin, though they retained within the gene pool the capability to develop dark skin when they migrated to areas with intense sunlight again, such as across the Bering Strait and south to the Equator. Human migration denotes any movement by Humans from one locality to another sometimes over long distances or The Bering Strait (Берингов пролив Beringov proliv) is a sea Strait between Cape Dezhnev, Russia, the easternmost point (169°43' (Chaplin)

Adaptive origins of skin color variation among humans

Dark brown skin is the ancestral (or original) skin color for modern humans (Harding et al 2000). This is due to humanity's common origin in equatorial Africa (a place in which UV protection is crucial) ~200,000 years ago (Tishkoff, 1996). This trait (dark skin) continues to be under strong selection in equatorial regions such as Africa, India, and New Guinea (Harding 2000). There is, in fact, evidence that those who dispersed from the original small group that left Africa ~60,000 years ago and settled in non-African equatorial regions (such as the mentioned India, New Guinea, and/or Australia) may have actually retained most of the ancestral sequence at the MC1R locus (Harding 2000 p 1355). Specifically, Harding et al (2000 p 1355) found that the haplotype sequences for Indians and New Guineans are virtually identical to those of continental sub-Saharan Africans. This retention of the ancestral trait at the equator is due to natural selection for pigment production in order to protect the body from harmful UV rays (Jablonski 2006). The retention is also analogous to that which occurred for natural Afro hair although certain evidence suggests that, unlike skin color, Afro hair ceased to be under strong selection once dark skin arose ~1 million years ago (Harding 2000) (rather, it remained as a vestigial trait among Africans and changed to straight in the north for adaptive reasons). Thus, the question becomes, how and why did the light skin of people of Eurasian descent come about?

According to (Norton et al., 2006), white skin observed in Europeans, South Asians , East Asians and North Africa (Maghreb) is due to independent genetic mutations in at least three loci. The European peoples are the various Nations and Ethnic groups of Europe. The Maghreb (المغرب العربي al-Maġrib al-ʿArabī) also rendered Maghrib (or rarely Moghreb) meaning "place of Sunset In biology mutations are changes to the Nucleotide sequence of the Genetic material of an organism In the fields of Genetics and Evolutionary computation, a locus (plural loci) is a fixed position on a Chromosome such as the position of a They concluded that light pigmentation is at least partially due to sexual selection. Sexual selection is the Theory proposed by Charles Darwin that states that certain evolutionary traits can be explained by Intraspecific competition

Several genes have been invoked to explain variations of skin tones in humans, including SLC45A2,[5] ASIP, MATP, TYR, and OCA2. Solute carrier family 45 member 2, also known as SLC45A2, is a human Gene. [6] A recently discovered gene, SLC24A5 has been shown to account for a substantial fraction of the difference in the average of 30 or so melanin units between Europeans and Africans. SLC24A5 ( solute carrier family 24 member 5) is a Gene that is thought to explain between 25 and 38% of Skin pigmentation variation between Black

Wide variations in human skin tones have been correlated with mutations in another gene; the MC1R gene [7]. History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance The melanocortin 1 receptor (also known as melanocyte-stimulating hormone receptor or Mc1r) is one of the key Proteins in regulating hair and skin color The "MC1R" label for the gene stands for melanocortin 1 receptor, where

Accordingly, the MC1R gene specifies the amino acid sequence in the receptor protein that relays through the cell membrane the hormone signal from the pituitary gland to produce the melanin that makes human skin very dark. Many variations in the amino acid sequence of this receptor protein result in lighter or darker skin.

The human MC1R gene consists of a string of 954 nucleotides, where each nucleotide is one of the four bases Adenine (A), Guanine (G), Thymine (T), or Cytosine (C). Nucleotides are Organic compounds that consist of three joined structures a nitrogenous base a Sugar, and a Phosphate group Adenine is a Purine with a variety of roles in Biochemistry including Cellular respiration, in the form of both the energy-rich Adenosine Guanine is one of the five main Nucleobases found in the Nucleic acids DNA and RNA, the others being Adenine, Cytosine, Thymine is one of the four bases in the Nucleic acid of DNA that make up the letters ATGC Cytosine is one of the five main bases found in DNA and RNA. It is a Pyrimidine derivative with a Heterocyclic Aromatic ring But 261 of the nucleotides in the MC1R gene can change with no effect on the amino acid sequence in the receptor protein produced from the gene. For example, the nucleotide triplets GGT, GGC, GGA, and GGG are all synonymous and all produce the amino acid Glycine[8], so a mutation in the third position in the triplet GGT is a "silent mutation" and has no effect on the amino acid produced from the triplet. This article deals with the general meaning of the term "synonym" Silent mutations are DNA Mutations that do not result in a change to the Amino acid sequence of a Protein. (Harding et al., 2000, pg. 1355) analyzed the amino acid sequences in the receptor proteins from 106 individuals from Africa and 524 individuals from outside Africa to find why the tone of all the Africans' skin was dark. Harding found that there were zero differences among the Africans for the amino acid sequences in their receptor proteins, so the skin of each individual from Africa was dark. In contrast, among the non-African individuals, there were 18 different amino acid sites in which the receptor proteins differed, and each amino acid that differed from the African receptor protein resulted in skin lighter than the skin of the African individuals. Nonetheless, the variations in the 261 silent sites in the MC1R were similar between the Africans and non-Africans, so the basic mutation rates among the Africans and non-Africans were the same. Why were there zero differences and no divergences in the amino acid sequences of the receptor protein among the Africans while there were 18 differences among the populations in Ireland, England, and Sweden?

(Harding et al., 2000, pp. 1359-1360) concluded that the intense sun in Africa created an evolutionary constraint that reduced severely the survival of progeny with any difference in the 693 sites of the MC1R gene that resulted in even one small change in the amino acid sequence of the receptor protein—because any variation from the African receptor protein produced significantly lighter skin that gave less protection from the intense African sun. In contrast, in Sweden, for example, the sun was so weak that no mutation in the receptor protein reduced the survival probability of progeny. Indeed, for the individuals from Ireland, England, and Sweden, the mutation variations among the 693 gene sites that caused changes in amino acid sequence was the same as the mutation variations in the 261 gene sites at which silent mutations still produced the same amino acid sequence. Thus, Harding concluded that the intense sun in Africa selectively killed off the progeny of individuals who had a mutation in the MC1R gene that made the skin lighter. However, the mutation rate toward lighter skin in the progeny of those African individuals who had moved North to areas with weaker sun was comparable to the mutation rate of the folks whose ancient ancestors grew up in Sweden. Hence, Harding concluded that the lightness of human skin was a direct result of random mutations in the MC1R gene that were non-lethal at the latitudes of Sweden. Even the mutations that produce red hair with little ability to tan were non-lethal in the northern latitudes.

(Rogers, Iltis & Wooding 2004) examined Harding's data on the variation of MC1R nucleotide sequences for people of different ancestry to determine the most probable progression of the skin tone of human ancestors over the last five million years. Comparing the MC1R nucleotide sequences for chimpanzees and humans in various regions of the Earth, Rogers concluded that the common ancestors of all humans had light skin tone under dark hair—similar to the skin tone and hair color pattern of today's chimpanzees. That is 5 million years ago, the human ancestors' dark hair protected their light skin from the intense African sun so that there was no evolutionary constraint that killed off the progeny of those who had mutations in the MC1R nucleotide sequences that made their skin light. (Sweet 2002) argues that based on cave paintings, Europeans may have been dark as recently as 13,000 years ago. The painters depicted themselves as having darker complexions than the animals they hunted.

However, over 1. 2 million years ago, judging from the numbers and spread of variations among human and chimpanzee MC1R nucleotide sequences, the human ancestors in Africa began to lose their hair and they came under increasing evolutionary pressures that killed off the progeny of individuals that retained the inherited lightness of their skin. Folate breakdown in sun-exposed skin is inhibited by the presence of melanin and is essential for human fetal development. It is likely that folate conservation played an important role in the selection of dark skin in the ancient African ancestors of modern humans. By 1. 2 million years ago, all people having descendants today had exactly the receptor protein of today's Africans; their skin was dark, and the intense sun killed off the progeny with any lighter skin that resulted from mutational variation in the receptor protein (Rogers, Iltis & Wooding 2004, p.  107).

However, the progeny of those humans who migrated North away from the intense African sun had another evolutionary constraint: vitamin D availability. Human requirements for vitamin D (cholecalciferol) are in part met through photoconversion of a precursor to vitamin D3. As humans migrated north from the equator, they were exposed to less intense sunlight, in part because of the need for greater use of clothing to protect against the colder climate. Thus, under these conditions, evolutionary pressures would tend to select for lighter-skinned humans as there was less photodestruction of folate and a greater need for photogeneration of cholecalciferol. Tracking back the statistical patterns in variations in DNA among all known people sampled who are alive on the Earth today, it appears that

  1. From 1. 2 million years ago for a million years, the ancestors of all people alive were as dark as today's Africans.
  2. For that period of a million years, human ancestors lived naked without clothing.
  3. The descendants of any people who migrate North from equatorial Africa will mutate to become light over time because the evolutionary constraint keeping Africans' skin dark decreases generally the further North a people migrates[9].

See also

Footnotes

  1. ^ Frost, Peter (2006). Albinism (from Latin albus, "white" see extended etymology) is a form of hypopigmentary Congenital disorder, Argyria (ISV from Greek: ἄργυρος argyros Silver + -ia is a Condition caused by the ingestion of elemental Silver, silver Complexion refers to the natural color texture and appearance of the Skin, especially that of the face Variations in the physical appearance of humans, known as human looks, are believed by Anthropologists to be an important factor in the development of personality and Human migration denotes any movement by Humans from one locality to another sometimes over long distances or In Dermatology, hyperpigmentation is the darkening of an area of Skin or nails caused by increased Melanin. A pigmentocracy is a group-based Social hierarchy based largely on Human skin color, spanning across ethnic religious gender and socio-economic groups The term race or racial group usually refers to the concept of categorizing Humans into Populations or groups on the basis of various sets Sunlight, in the broad sense is the total spectrum of the Electromagnetic radiation given off by the Sun. Sun tanning describes a darkening of the skin (especially of fair-skinned individuals in a natural physiological response stimulated by exposure to ultraviolet (UV radiation Von Luschan's chromatic scale is a method of classifying Skin color. Why Do Europeans Have So Many Hair and Eye Colors?. University of California – Los Angeles. Retrieved on 2007-10-15. Year 2007 ( MMVII) was a Common year starting on Monday of the Gregorian calendar in the 21st century. Events 533 - Byzantine General Belisarius makes his formal entry into Carthage, having conquered it from the
  2. ^ Norton et al., 2006
  3. ^ Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease - Holick 80 (6): 1678S - American Journal of Clinical Nutrition
  4. ^ (Jablonski & Chaplin 2000, p.  67), formula coefficients have been rounded to one-figure accuracy
  5. ^ SpringerLink - Journal Article
  6. ^ http://backintyme.com/admixture/shriver01.pdf
  7. ^ Harding et al., 2000, pg. 1351
  8. ^ See DNA Codon Table
  9. ^ (Rogers, Iltis & Wooding 2004), (Jablonski 2004)

References

Further reading

External links


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