Citizendia

F. Hoffmann–La Roche, Ltd.
TypePublic (parent company Roche Holding AG traded under RHHBY. PK)
Founded1896
HeadquartersFlag of Switzerland Basel, Switzerland, Roche US in Nutley, NJ
Key peopleSeverin Schwan (CEO)
William M. Year 1896 ( MDCCCXCVI) was a Leap year starting on Wednesday (link will display the full calendar of the Gregorian Calendar (or a Leap year "Basilia" redirects here For the Fly Genus, see Basilia (fly. This article is about the township of Nutley in New Jersey For the village in East Sussex see Nutley East Sussex. A chief executive officer ( CEO) or chief executive is typically the highest-ranking corporate officer ( executive) or administrator Burns (CEO of pharmaceuticals division)
Jonathan Knowles (Director of Research)
IndustryPharmaceutical
ProductsXenical, Valium, Zenapax, Valcyte, Bactrim, Tarceva, CellCept
Revenue28. A chief executive officer ( CEO) or chief executive is typically the highest-ranking corporate officer ( executive) or administrator For other uses of this term see Industry (disambiguation An industry (from Latin industrius, "diligent industrious" In Marketing, a product is anything that can be offered to a Market that might satisfy a want or need Orlistat (marketed under the trade name Xenical by Roche; or over-the-counter as alli by GlaxoSmithKline (ˈælaɪ like the English Diazepam (daɪˈæzɨpæm first marketed as Valium by Hoffmann-La Roche, is a Benzodiazepine derivative Drug. Daclizumab ( Zenapax) is a therapeutic humanized Monoclonal antibody to the alpha subunit of the IL-2 receptor of T cells. Valganciclovir hydrochloride ( Valcyte, manufactured by Roche is an Antiviral Medication used to treat Cytomegalovirus Infections Co-trimoxazole (abbreviated SXT TMP-SMX TMP-SMZ or TMP-sulfa is an Sulphonamide, Antibacterial combination of Trimethoprim and Sulfamethoxazole Erlotinib hydrochloride (originally coded as OSI-774) is a drug used to treat non-small cell Lung cancer, Pancreatic cancer and several other Mycophenolic acid ( INN) (ˌmaɪkoʊˈfɛnɒlɪk or mycophenolate is an immunosuppressant drug used to prevent rejection in Organ transplantation In business revenue or revenues is Income that a company receives from its normal business activities usually from the sale of goods and services 6 billion (2005)
Employees74,372 (2006)
Websitehttp://www.roche.com/

F. Employment is a Contract between two parties, one being the employer and the other being the employee. A website (alternatively web site or Web site, a back-construction from the Proper noun World Wide Web) is a collection of Web pages Hoffmann–La Roche, Ltd. is a Swiss global health-care company which operates world-wide under two divisions: Pharmaceuticals and Diagnostics. Switzerland (English pronunciation; Schweiz Swiss German: Schwyz or Schwiiz Suisse Svizzera Svizra officially the Swiss Confederation Roche Diagnostics Division is a subsidiary of Hoffmann-La Roche which manufactures equipment and reagents for research and medical diagnostic applications It belongs to the Roche Holding AG.

The headquarters are in Basel and the company has many sites around the world - including: Nutley, Palo Alto, Pleasanton, Branchburg, Indianapolis, and Florence in the US, Welwyn Garden City and Burgess Hill in the UK, Mannheim and Penzberg in Germany, and Shanghai in China. "Basilia" redirects here For the Fly Genus, see Basilia (fly. This article is about the village of Nutley in East Sussex For the township in Essex County New Jersey see Nutley New Jersey. Palo Alto (ˌpæloʊˈæltoʊ from Spanish: palo: "stick" and alto: "high" i Pleasanton is a city in Alameda County, California, incorporated in 1894 Branchburg Township is a Township in Somerset County, New Jersey, United States. Florence is the largest city in and the County seat of Florence County, South Carolina, United States. The United States of America —commonly referred to as the Welwyn Garden City is a Town in Hertfordshire, England. Welwyn Garden City is also referred to in Council parlance as WGC or less correctly Burgess Hill is a town and Civil parish in the Mid Sussex district of West Sussex, England, close to the border with East Sussex The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom, the UK or Britain,is a Sovereign state located Mannheim is a City in Germany. With 327318 inhabitants it is the second-largest city in the state of Baden-Württemberg after the capital Stuttgart Penzberg is a Town in the Weilheim-Schongau district in Bavaria, Germany. Germany, officially the Federal Republic of Germany ( ˈbʊndəsʁepuˌbliːk ˈdɔʏtʃlant is a Country in Central Europe. Shanghai ( 上[[wikt 海|海]] is the largest city in China in terms of population and one of the largest urban areas in the world with over 20 million China ( Wade-Giles ( Mandarin) Chung¹kuo² is a cultural region, an ancient Civilization, and depending on perspective a National

The company also owns a majority of the American biotechnology company Genentech and the Japanese biotechnology company Chugai Pharmaceuticals. Genentech Inc ( a composite of Genetic Engineering Technology Inc

Roche Holding AG (ticker ROC. S) is listed on the London-based virt-x stock exchange (virt-x is a company of the SWX Swiss Exchange). SWX Swiss Exchange is Switzerland 's Stock exchange, based in Zürich. Roche's revenues during fiscal year 2005 were $28. Year 2005 ( MMV) was a Common year starting on Saturday (link displays full calendar of the Gregorian calendar. 6 billion (2005, 35. 5bn CHF). The franc ( German: Franken, French and Romansh: franc, Italian: franco; code: CHF Descendants of the founding Hoffmann and Oeri families own half of the company. Swiss pharma company Novartis owns 33% of the company (as of 2005). Novartis International AG is a multinational Pharmaceutical company based in Basel Switzerland that manufactures drugs such as Clozapine

Contents

History

Founded in 1896 by Fritz Hoffmann-La Roche, the company was early on known for producing various vitamin preparations and derivatives. Year 1896 ( MDCCCXCVI) was a Leap year starting on Wednesday (link will display the full calendar of the Gregorian Calendar (or a Leap year Fritz Hoffmann, The founder of Hoffmann-La Roche was born in Basel, Switzerland on 24 October 1868, and died on 18 April A vitamin is an Organic compound required as a Nutrient in tiny amounts by an Organism. In 1934, it became the first company to mass produce synthetic vitamin C, under the brand name Redoxon. Year 1934 ( MCMXXXIV) was a Common year starting on Monday (link will display full 1934 calendar of the Gregorian calendar. Redoxon is the brand name of the first artificially synthesised Vitamin C to be sold to the public In 1957 it introduced the class of tranquilizers known as benzodiazepines (with Valium and Rohypnol being the best known members). Year 1957 ( MCMLVII) was a Common year starting on Tuesday (link displays the 1957 Gregorian calendar) A sedative, or more specifically a sedative-hypnotic, is a substance that depresses the Central nervous system (CNS resulting in calmness relaxation sleepiness The benzodiazepines (pronounced, often abbreviated to "benzos") are a class of Psychoactive drugs with varying Hypnotic Diazepam (daɪˈæzɨpæm first marketed as Valium by Hoffmann-La Roche, is a Benzodiazepine derivative Drug. Flunitrazepam (ˌfluːnaɪˈtræzəpæm is a highly potent Hypnotic drug with powerful Sedative, Anxiolytic, Amnestic, and Skeletal Its acne drug isotretinoin, marketed as Accutane and Roaccutane, has also been used as a form of chemotherapy for some cancers [1], has been linked with a number of very severe side effects and remains highly controversial. Acne vulgaris (commonly called acne) is a Skin disease caused by changes in the Pilosebaceous units (skin structures consisting of a Hair follicle Isotretinoin ( INN) (aɪsoʊtrɨˈtɪnoʊɨn or /ˌaɪsoʊtrɨˈtɪnoʊɨn/ is a Medication used for the treatment of severe acne. Chemotherapy, in its most general sense refers to treatment of disease by chemicals that kill cells specifically those of micro-organisms or Cancer. Roche has also produced various HIV tests and antiretroviral drugs. HIV tests are used to detect the presence of the Human immunodeficiency virus in serum, Saliva, or Urine. It bought the patents for the polymerase chain reaction technique in 1992. A patent is a set of Exclusive rights granted by a State to an inventor or his assignee for a fixed period of time in exchange for a disclosure of an Year 1992 ( MCMXCII) was a Leap year starting on Wednesday (link will display full 1992 Gregorian calendar) It manufactures and sells several cancer drugs. Cancer (medical term Malignant Neoplasm) is a class of Diseases in which a group of cells display uncontrolled

In 1976, an accident at a chemical factory in Seveso, Italy owned by a subsidiary of Roche caused a large dioxin contamination; see Seveso disaster. Year 1976 ( MCMLXXVI) was a Leap year starting on Thursday (link will display full calendar of the Gregorian calendar. Seveso (in Lombard language Séves) is an Italian town and Comune of 19872 inhabitants situated in the Province of Milan Italy (Italia officially the Italian Republic, (Repubblica Italiana is located on the Italian Peninsula in Southern Europe, and on the two largest Not to be confused with Dioxane or Digoxin. Dioxin is a heterocyclic, organic, antiaromatic compound The Seveso disaster was an industrial accident that occurred around 1237 pm July 10, 1976, in a small chemical manufacturing plant approximately 25 km north of

In 1982, the United States arm of the company acquired Biomedical Reference Laboratories for US$163. 5 million. That company dated from the late 1960s, and was located in Burlington, North Carolina. Burlington is a city in Alamance and Guilford counties in the U That year Hoffmann-La Roche then merged it with all of its laboratories, and incorporated the merged company as Roche Biomedical Laboratories, Inc. in Burlington. By the early 1990s, Roche Biomedical became one of the largest clinical laboratory networks in the United States, with 20 major laboratories and US$600 million in sales. [2]

On April 28, 1995 Hoffmann-La Roche sold Roche Biomedical Laboratories, Inc. Events 1192 - Assassination of Conrad of Montferrat (Conrad I King of Jerusalem, in Tyre, two days after his title Year 1995 ( MCMXCV) was a Common year starting on Sunday. Events of 1995 to National Health Laboratories Holdings Inc. (formerly NYSE: NH), which then changed its name to Laboratory Corporation of America Holdings (NYSE: LH). The New York Stock Exchange ( NYSE) is a Stock exchange based in New York City. Laboratory Corporation of America Holdings ( more commonly known as LabCorp, is an S&P 500 company in Burlington, North Carolina, and one of The New York Stock Exchange ( NYSE) is a Stock exchange based in New York City. [3] In 1994, Roche acquired Syntex. Laboratorios Syntex SA was a pharmaceutical company formed in Mexico City in 1944 by Russell Marker to manufacture therapeutic steroids from the Mexican yam

Creation of the first anti-depressant

In 1956, Iproniazid was accidentally created during an experiment while synthesizing Isoniazid. Year 1956 ( MCMLVI) was a Leap year starting on Sunday (link will display full calendar of the Gregorian calendar. Iproniazid ( iproniazid phosphate, marketed under the names Marsilid, Iprozid, Ipronid, Rivivol, Propilniazida) is a monoamine Isoniazid (also called isonicotinyl hydrazine or INH) is a first-line antituberculous medication used in the prevention and treatment of Tuberculosis Originally, it had been intended to create a more efficient drug at combatting Tuberculosis. Tuberculosis (abbreviated as TB for tubercle bacillus or T u' b' erculosis Bacillus --> is a common Iproniazid, however, revealed to have its own benefits; some people felt it made them feel happier. Iproniazid ( iproniazid phosphate, marketed under the names Marsilid, Iprozid, Ipronid, Rivivol, Propilniazida) is a monoamine It was withdrawn from the market in the early 1960s due to toxic side-effects.

Vitamin price fixing

Stanley Adams, Roche's World Product Manager in Basel, contacted the European Economic Community in 1973 with evidence that Roche had been breaking antitrust laws, engaging in price fixing and market sharing for vitamins with its competitors. Stanley Adams (born c1927 is a former Pharmaceutical company executive and corporate Whistleblower, whose case was a cause célèbre in the 1970s The European Community (EC is one of the Three pillars of the European Union (EU created under the Maastricht Treaty (1992 Roche was fined accordingly, but a bungle on the part of the EEC allowed the company to discover that it was Adams who had blown the whistle. He was arrested for unauthorised disclosure — an offence under Swiss law — and imprisoned. His wife, having learnt that he might face decades in jail, committed suicide. [4] Adams was released soon after but arrested again more than once before eventually fleeing to Britain, where he wrote a book about the affair, Roche Versus Adams (London, 1984, ISBN 022402180X).

In 1999 Roche was the worldwide market leader in vitamins, with a market share of 40%. Between 1990 and 1999, the company continued to participate in an illegal price fixing cartel for vitamins, which also included BASF and Rhone-Poulenc SA. BASF SE () is a German chemical company and the largest chemical company in the world In 1999, Roche pleaded guilty in the United States and paid a US$500 million fine, then the largest fine ever secured in the U. The United States of America —commonly referred to as the The United States dollar ( sign: $; code: USD) is the unit of Currency of the United States; it has also been S. The European Commission fined Roche €462 million for the same infraction in 2001, also a record fine at the time. The European Commission (formally the Commission of the European Communities) is the executive branch of the European Union. Please update other articles as well to avoid contradiction within Wikipedia e [4]

Roche sold its vitamin business in late 2002 to the Dutch group DSM. DSM (in full Koninklijke DSM NV, or Royal DSM NV) is a multinational company specialized in life science and performance materials

Alleged Tamiflu monopoly

In a recent meeting of regional health ministers, Dr. Francisco J. Duque III, Secretary of the Philippines Department of Health, accused Roche of "monopolizing" the production and distribution of the drug known as Oseltamivir (brand name Tamiflu). The Philippines ( Filipino: Pilipinas, officially known as the Republic of the Philippines (fil ''Republika ng Pilipinas'' RP Oseltamivir ( INN) (ɒsəlˈtæmɨvɪr is an Antiviral drug that is used in the treatment and Prophylaxis of both Influenzavirus A and Influenzavirus Oseltamivir ( INN) (ɒsəlˈtæmɨvɪr is an Antiviral drug that is used in the treatment and Prophylaxis of both Influenzavirus A and Influenzavirus Oseltamivir is considered to be the primary antiviral drug used to combat avian influenza, commonly known as the bird flu. Influenza A virus subtype H5[[Neuraminidase N1]], also known as A(H5N1 or simply H5N1, is a subtype of the Influenza A virus which can cause Roche is the only drug company authorized to manufacture the drug, which was discovered by Gilead Sciences. Gilead Sciences is a Biopharmaceutical company that discovers develops and commercializes Therapeutics to advance the care of patients suffering from life-threatening Roche purchased the rights to the drug in 1996 and in 2005 settled a royalty dispute, agreeing to pay Gilead tiered royalties of 14-22% of annual net sales. [5]

The Philippine health secretary complained that the supply of the said drug is only concentrated in First World countries even if the disease is ravaging bird and poultry populations in Southeast Asia as of this time. The term " first world " refers to countries that are capitalist, which are technologically advanced and whose Dr. Duque proposed that even if Roche is the only one who has the patent for the drug, special patents or licenses should be granted to other drug companies to manufacture the drug and make it more accessible to avian flu-vulnerable countries in Southeast Asia such as Vietnam, Indonesia, Cambodia and the Philippines. Vietnam (ˌviːɛtˈnɑːm Việt Nam) officially The Republic of Indonesia ( (Republik Indonesia is a Country in Southeast Asia. The Kingdom of Cambodia ( formerly known as Kampuchea (, transliterated: Preăh Réachéanachâkr Kâmpŭchea) is a country in South East The Philippines ( Filipino: Pilipinas, officially known as the Republic of the Philippines (fil ''Republika ng Pilipinas'' RP Duque and Philippine president Gloria Macapagal Arroyo have already communicated with the representative of the World Health Organization in the Philippines asking for assistance in calling for greater production and distribution of Oseltamivir. Maria Gloria Macapagal-Arroyo (born Maria Gloria Macaraeg Macapagal on April 5 1947 is a Filipina Politician.

World leaders, such as former UN Secretary General Kofi Annan, have expressed a desire to have more generic versions of Tamiflu made, especially for Third World countries too poor to buy the brand name drug. The Secretary-General of the United Nations is the head of the Secretariat, one of the principal organs of the United Nations. Kofi Atta Annan, GCMG (born 8 April 1938 is a Ghanaian Diplomat who served as the seventh Secretary-General of the United Nations Third World is a name given to nations that are generally considered to be underdeveloped economically

On October 20, 2005, Hoffmann-La Roche decided to license other companies to manufacture Oseltamivir. Events 1740 - Maria Theresa takes the throne of Austria. France, Prussia, Bavaria and Saxony Year 2005 ( MMV) was a Common year starting on Saturday (link displays full calendar of the Gregorian calendar. [6]

Additional key persons

In addition to corporate executive committee members mentioned in the summary information box

Enlarged Corporate Executive Committee

Company profiles

External links

References

  1. ^ [1], Roaccutane Science
  2. ^ Roche Biomedical Laboratories, Inc., FundingUniverse. com
  3. ^ Laboratory Corp of America Holdings · 10-Q · For 3/31/95, SECInfo. com, Filed On 5/15/95, SEC File 1-11353, Accession Number 920148-95-11
  4. ^ a b Blowing the final whistle, The Observer, 25 November 2001
  5. ^ "Roche, Gilead End Tamiflu Feud", Red Herring, November 16, 2005.  
  6. ^ Kher, Unmesh (2005-10-19). Year 2005 ( MMV) was a Common year starting on Saturday (link displays full calendar of the Gregorian calendar. Events 202 BCE - The Battle of Zama results in the defeat of Carthage and Hannibal. Why Roche Released Tamiflu. Time. Time Inc. . Retrieved on 2008-05-22. 2008 ( MMVIII) is the current year in accordance with the Gregorian calendar, a Leap year that started on Tuesday of the Common Events 334 BC - The Greek army of Alexander the Great defeats Darius III of Persia in the Battle of the Granicus.
© 2009 citizendia.org; parts available under the terms of GNU Free Documentation License, from http://en.wikipedia.org
 Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic