Hodgkin's lymphoma Classification and external resources
Lymph node biopsy showing Hodgkin's lymphoma.
ICD-10	C81.
ICD-9	201
ICD-O:	9650/3-9667/3
DiseasesDB	5973
MedlinePlus	000580
eMedicine	med/1022
MeSH	D006689

Hodgkin's lymphoma, also known as Hodgkin's disease, is a type of lymphoma first described by Thomas Hodgkin in 1832. The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify Diseases The International Statistical Classification of Diseases and Related Health Problems 10th Revision ( ICD -10) is a coding of diseases and signs symptoms abnormal findings The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify Diseases The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. The International Classification of Diseases for Oncology (ICD-O is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems The Diseases Database is a free Website that provides information about the relationships between medical conditions Symptoms, and Medications. MedlinePlus, with the MedlinePlus Medical Encyclopedia, is a website network containing Health information from the world's largest medical Library eMedicine is an online clinical medical knowledge base that was founded in 1996 by Scott Plantz and Richard Lavely two medical doctors Medical Subject Headings ( MeSH) is a huge Controlled vocabulary (or metadata system for the purpose of indexing journal articles and books Lymphoma a type of Neoplasm that originates in Lymphocytes (a type of White blood cell in the vertebrate Immune system) For the British historian his nephew with the same name see Thomas Hodgkin. Hodgkin's lymphoma is characterized clinically by the orderly spread of disease from one lymph node group to another and by the development of systemic symptoms with advanced disease. A Lymph node ( lɪmf noʊd is an organ consisting of many types of cells and is a part of the Lymphatic system. B symptoms refer to Systemic symptoms of Fever, Night sweats and Weight loss which can be associated with both Hodgkin's lymphoma Pathologically, the disease is characterized by the presence of Reed-Sternberg cells. Reed-Sternberg cells (Lacunar Histiocytes for certain types are different giant cells found on Light microscopy in biopsies from individuals with Hodgkin's Hodgkin's lymphoma was one of the first cancers to be cured by radiation. Cancer (medical term Malignant Neoplasm) is a class of Diseases in which a group of cells display uncontrolled Later it was one of the first to be cured by combination chemotherapy. The era of cancer Chemotherapy began in the 1940s with the first use of Nitrogen mustards and Folic acid antagonist drugs The cure rate is about 93%, making it one of the most curable forms of cancer—if it is detected in the early stages. Later-stage cancers show a significantly worse prognosis^[1]. The Handbook of Cancer Chemotherapy, Sixth Edition states that "the potential for cure should not lead clinicians and patients to lose sight of the fact that [Hodgkin's lymphoma] is a malignancy and that approximately 20% to 25% of patients. . . die of the disease. "^[2]

Contents 1 Epidemiology 2 Symptoms 3 Diagnosis 4 Pathology 4.1 Macroscopy 4.2 Microscopy 5 Types 6 Staging 7 Prognosis 8 Treatment 9 Notable cases 10 Cultural references 11 See also 12 References 13 Headline text 14 External links

Epidemiology

Unlike some other lymphomas, whose incidence increases with age, Hodgkin's lymphoma has a bimodal incidence curve; that is, it occurs most frequently in two separate age groups, the first being young adulthood (age 15–35) and the second being in those over 55 years old although these peaks may vary slightly with nationality. The non-Hodgkin lymphomas are a diverse group of hematologic cancers which encompass any Lymphoma other than Hodgkin lymphoma. Incidence is a measure of the risk of developing some new condition within a specified period of time ^[3] Overall, it is more common in males, except for the nodular sclerosis variant (see below), which is more common in females. Nodular sclerosis (or "NSHL" is a form of Hodgkin's lymphoma which is the most common subtype of HL in developed countries

The annual incidence of Hodgkin's lymphoma is about one in 25,000 people, and the disease accounts for slightly less than 1% of all cancers worldwide.

The incidence of Hodgkin's lymphoma is increased in patients with HIV infection. ^[4] In contrast to many other lymphomas associated with HIV infection it occurs most commonly in patients with higher CD4 T cell counts.

Symptoms

Patients with Hodgkin's lymphoma may present with the following symptoms:

• Lymph nodes: the most common symptom of Hodgkin's is the painless enlargement of one or more lymph nodes. A Lymph node ( lɪmf noʊd is an organ consisting of many types of cells and is a part of the Lymphatic system. The nodes may also feel rubbery and swollen when examined by a physician. The nodes of the neck and shoulders (cervical and supraclavicular) are most frequently involved (80-90% of the time, on average). In Anatomy, ' cervical' is an Adjective that has two meanings of or pertaining to any Neck. The supraclavicular nerves (descending branches arise from the third and fourth Cervical nerves; they emerge beneath the posterior border of the Sternocleidomastoideus The lymph nodes of the chest are often affected and these may be noticed on a chest radiograph. A chest X-ray, commonly abbreviated CXR, is a projection radiograph ( X-ray) taken by a Radiographer, of the Thorax which is used

• Splenomegaly: enlargement of the spleen occurs in about 30% of people with Hodgkin's lymphoma. Splenomegaly is an enlargement of the Spleen, which usually lies in the left upper quadrant (LUQ of the Human abdomen. The spleen is an organ found in all Vertebrate animals In humans the spleen is located in the abdomen of the body where it functions in the destruction of redundant Red The enlargement, however, is seldom massive and the size of the spleen may fluctuate during the course of treatment. ^[5]

• Hepatomegaly: enlargement of the liver, due to liver involvement, is present in about five percent of cases. Hepatomegaly is the condition of having an enlarged Liver. It is a nonspecific medical sign having many causes which can broadly be broken down into Infection The liver is a vital organ in the human body and is present in Vertebrates and some other animals

• Hepatosplenomegaly: the enargement of both the liver and spleen caused by the same disease. Hepatosplenomegaly is the simultaneous enlargement of both the Liver ( Hepatomegaly) and the Spleen ( Splenomegaly)

• Pain:
  • Pain following alcohol consumption: classically, involved nodes are painful after alcohol consumption, though this phenomenon is rare^[6]. Pain, in the sense of physical pain, is a typical sensory experience that may be described as the unpleasant awareness of a noxious stimulus or bodily harm
  • Back pain: nonspecific back pain (pain that cannot be localized or its cause determined by examination or scanning techniques) has been reported in some cases of Hodgkin's lymphoma. Back pain (also known " dorsalgia " is Pain felt in the back that usually originates from the Muscles Nerves Bones

• Systemic symptoms: about one-third (⅓) of patients with Hodgkin's disease may also present with systemic symptoms, including low-grade fever; night sweats; unexplained weight loss of at least 10% of the patient's total body mass in six months or less, itchy skin (pruritus) due to increased levels of eosinophils in the bloodstream; or fatigue (lassitude). Fever (also known as pyrexia, from the Greek pyretos meaning fire or a febrile response, from the Latin word Febris Sleep hyperhidrosis, more commonly known as the night sweats, is the occurrence of excessive sweating ( Hyperhidrosis) during Sleep. Itch ( Latin: pruritus) is an unpleasant Sensation that evokes the desire or Reflex to scratch Eosinophil granulocytes, usually called eosinophils (or less commonly acidophils) are White blood cells that are one of the Immune System components Systemic symptoms such as fever, night sweats, and weight loss are known as B symptoms; thus, presence of fever, weight loss, and night sweats indicate that the patient's stage is, for example, 2B instead of 2A^[7]. B symptoms refer to Systemic symptoms of Fever, Night sweats and Weight loss which can be associated with both Hodgkin's lymphoma

• Cyclical fever: patients may also present with a cyclical high-grade fever known as the Pel-Ebstein fever^[8], or more simply "P-E fever". Pel-Ebstein fever is a rarely seen condition noted in patients with Hodgkin's lymphoma in which the patient experiences Fevers which cyclicly increase then decrease However, there is debate as to whether or not the P-E fever truly exists^[9].

Diagnosis

Hodgkin's lymphoma must be distinguished from non-cancerous causes of lymph node swelling (such as various infections) and from other types of cancer. Definitive diagnosis is by lymph node biopsy (Usually excisional biopsy with microscopic examination). A biopsy (in Greek: βίος life and όψη look/appearance is a Medical test involving the removal of cells or tissues Blood tests are also performed to assess function of major organs and to assess safety for chemotherapy. A blood test is a laboratory analysis performed on a Blood sample that is usually extracted from a Vein in the arm using a needle, or via Chemotherapy, in its most general sense refers to treatment of disease by chemicals that kill cells specifically those of micro-organisms or Cancer. Positron emission tomography (PET) is used to detect small deposits that do not show on CT scanning. Positron emission tomography ( PET) is a Nuclear medicine imaging technique which produces a three-dimensional image or map of functional processes in the In some cases a Gallium Scan may be used instead of a PET scan. Gallium imaging is a Nuclear medicine method for the detection of Infections and Cancers Radioactive Gallium -67 binds to

Pathology

Macroscopy

Affected lymph nodes (most often, laterocervical lymph nodes) are enlarged, but their shape is preserved because the capsule is not invaded. Usually, the cut surface is white-grey and uniform; in some histological subtypes (e. g. nodular sclerosis) a nodular aspect may appear. Nodular sclerosis (or "NSHL" is a form of Hodgkin's lymphoma which is the most common subtype of HL in developed countries

Microscopy

Microscopic examination of the lymph node biopsy reveals complete or partial effacement of the lymph node architecture by scattered large malignant cells known as Reed-Sternberg cells (typical and variants) admixed within a reactive cell infiltrate composed of variable proportions of lymphocytes, histiocytes, eosinophils, and plasma cells. The Reed-Sternberg cells are identified as large often bi-nucleated cells with prominent nucleoli and an unusual CD45-, CD30+, CD15+/- immunophenotype. In Immunology, the CD45 Antigen (CD stands for Cluster of differentiation) is a Protein which was originally called leukocyte common antigen CD30, also known as TNFRSF8, is a cell membrane CD15 (3-fucosyl-N-acetyl-lactosamine is a Cluster of differentiation - an immunologically significant molecule In approximately 50% of cases, the Reed-Sternberg cells are infected by the Epstein-Barr virus. The Epstein-Barr Virus ( EBV) also called Human herpesvirus 4 (HHV-4 is a Virus of the herpes family (which includes Herpes A virus (from the Latin virus meaning Toxin or Poison) is a sub-microscopic infectious agent that is unable

Characteristics of classic Reed-Sternberg cells include large size (20–50 micrometres), abundant, amphophilic, finely granular/homogeneous cytoplasm; two mirror-image nuclei (owl eyes) each with an eosinophilic nucleolus and a thick nuclear membrane (chromatin is distributed at the cell periphery). Chromatin is the complex basis of DNA and protein that makes up Chromosomes It is found inside the nuclei of eukaryotic cells, and within the

Variants:

• Hodgkin's cell (atypical mononuclear RSC) is a variant of RS cell, which has the same characteristics, but is mononucleated.
• Lacunar RSC is large, with a single hyperlobated nucleus, multiple, small nucleoli and eosinophilic cytoplasm which is retracted around the nucleus, creating an empty space ("lacunae").
• Pleomorphic RSC has multiple irregular nuclei.
• "Popcorn" RSC (lympho-histiocytic variant) is a small cell, with a very lobulated nucleus, small nucleoli.
• "Mummy" RSC has a compact nucleus, no nucleolus and basophilic cytoplasm. ^[10]

Hodgkin's lymphoma can be sub-classified by histological type. The cell histology in Hodgkin's lymphoma is not as important as it is in non-Hodgkin's lymphoma: the treatment and prognosis in Hodgkin's lymphoma depend on the stage of disease rather than the histotype. The non-Hodgkin lymphomas are a diverse group of hematologic cancers which encompass any Lymphoma other than Hodgkin lymphoma.

Types

Classical Hodgkin's lymphoma (excluding nodular lymphocyte predominant Hodgkin's) can be subclassified into 4 pathologic subtypes based upon Reed-Sternberg cell morphology and the composition of the reactive cell infiltrate seen in the lymph node biopsy specimen. (M9650/3)

Family	Name	Description	ICD-10	ICD-O
Classical	Nodular sclerosing CHL	Is the most common subtype and is composed of large tumor nodules with lacunar RS cells subtype composed of numerous classic often pleomorphic RS cells with only few reactive lymphocytes which may easily be confused with diffuse large cell lymphoma. The International Classification of Diseases for Oncology (ICD-O is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems The International Statistical Classification of Diseases and Related Health Problems 10th Revision ( ICD -10) is a coding of diseases and signs symptoms abnormal findings The International Classification of Diseases for Oncology (ICD-O is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems See also Cancer A tumor or tumour is the name for a swelling or lesion formed by an abnormal growth of cells (termed neoplastic	C81.1	M9663/3
Classical	Mixed-cellularity subtype	Is a common subtype and is composed of numerous classic RS cells admixed with numerous inflammatory cells including lymphocytes, histiocytes, eosinophils, and plasma cells. The International Classification of Diseases for Oncology (ICD-O is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems	C81.2	M9652/3
Classical	Lymphocyte-rich	Is a rare subtype. The International Classification of Diseases for Oncology (ICD-O is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems A lymphocyte is a type of White blood cell in the Vertebrate Immune system.	C81.0	M9651/3
Classical	Lymphocyte depleted	Is a rare subtype. The International Classification of Diseases for Oncology (ICD-O is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems	C81.3	M9653/3
Non-classical	Nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL)	Is no longer classified as a form of classic Hodgkin's lymphoma. The International Classification of Diseases for Oncology (ICD-O is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems This is due to the fact that the RSC variants (popcorn cells) that characterize this form of the disease invariably express B lymphocyte markers such as CD20 (thus making NLPHL an unusual form of B cell lymphoma), and that (unlike classic HL) NLPHL may progress to diffuse large B cell lymphoma. The B-cell lymphomas are types of Non-Hodgkin lymphoma affecting B cells. There are small but clear differences in prognosis between the various forms. Lymphocyte predominant HL is an uncommon subtype composed of vague nodules of numerous reactive lymphocytes admixed with large popcorn-shaped RSC. Unlike classic RSC, the non-classic popcorn-shaped RS cells of NLPHL are CD15 and CD30 negative while positive for the B cell marker CD20. CD15 (3-fucosyl-N-acetyl-lactosamine is a Cluster of differentiation - an immunologically significant molecule CD30, also known as TNFRSF8, is a cell membrane CD20 is a non- Glycosylated phosphoprotein expressed on the surface of all mature B-cells.	C81.7	M9659/3

Staging

After Hodgkin's lymphoma is diagnosed, a patient will be staged: that is, they will undergo a series of tests and procedures which will determine what areas of the body are affected. The International Classification of Diseases for Oncology (ICD-O is a domain specific extension of the International Statistical Classification of Diseases and Related Health Problems The stage of a cancer is a descriptor (usually numbers I to IV of how much the Cancer has spread These procedures will include documentation of their histology, a physical examination, blood tests, chest X-ray radiographs, computed tomography (CT) scans or magnetic resonance imaging (MRI) scans of the chest, abdomen and pelvis, and a bone marrow biopsy. X-radiation (composed of X-rays) is a form of Electromagnetic radiation. Computed tomography (CT is a Medical imaging method employing Tomography. Positron emission tomography (PET) scan is now used instead of the gallium scan for staging. Positron emission tomography ( PET) is a Nuclear medicine imaging technique which produces a three-dimensional image or map of functional processes in the A gallium scan or gallium 67 scan is a type of Nuclear medicine study that uses a radioactive tracer to obtain images of a specific type of tissue or disease In the past, a lymphangiogram or surgical laparotomy (which involves opening the abdominal cavity and visually inspecting for tumors) were performed. A lymphangiogram is a medical test whereby pictures of the Lymphatic system taken with X-rays after a special dye is injected to outline the Lymph nodes A laparotomy is a surgical procedure involving an incision through the Abdominal wall to gain access into the Abdominal cavity. Lymphangiograms or laparotomies are very rarely performed, having been supplanted by improvements in imaging with the CT scan and PET scan

On the basis of this staging, the patient will be classified according to a staging classification (the Ann Arbor staging classification scheme is a common one):

• Stage I is involvement of a single lymph node region (I) or single extralymphatic site (Ie);
• Stage II is involvement of two or more lymph node regions on the same side of the diaphragm (II) or of one lymph node region and a contiguous extralymphatic site (IIe);
• Stage III is involvement of lymph node regions on both sides of the diaphragm, which may include the spleen (IIIs) and/or limited contiguous extralymphatic organ or site (IIIe, IIIes);
• Stage IV is disseminated involvement of one or more extralymphatic organs. Ann Arbor staging is the staging system for Lymphomas both in Hodgkin's lymphoma (previously called Hodgkin's Disease and Non-Hodgkin lymphoma For other types of diaphragm see Diaphragm. In the Anatomy of Mammals the thoracic diaphragm is a sheet of Muscle The spleen is an organ found in all Vertebrate animals In humans the spleen is located in the abdomen of the body where it functions in the destruction of redundant Red

The absence of systemic symptoms is signified by adding 'A' to the stage; the presence of systemic symptoms is signified by adding 'B' to the stage.

Prognosis

In 1998, an international effort^[11] identified seven prognostic factors that accurately predict the success rate of conventional treatment in patients with locally extensive or advanced stage Hodgkin's lymphoma. Freedom from progression (FFP) at 5 years was directly related to the number of factors present in a patient. The 5-year FFP for patients with zero factors is 84%. Each additional factor lowers the 5-year FFP rate by 7%, such that the 5-year FFP for a patient with 5 or more factors is 42%.

The adverse prognostic factors identified in the international study are:

• Age >= 45 years
• Stage IV disease
• Hemoglobin < 10. 5 g/dl
• Lymphocyte count < 600/µl or < 8%
• Male
• Albumin < 4. 0 g/dl
• White blood count >= 15,000/µl

Other studies have reported the following to be the most important adverse prognostic factors: mixed-cellularity or lymphocyte-depleted histologies, male sex, large number of involved nodal sites, advanced stage, age of 40 years or more, the presence of B symptoms, high erythrocyte sedimentation rate, and bulky disease (widening of the mediastinum by more than one third, or the presence of a nodal mass measuring more than 10 cm in any dimension. The erythrocyte sedimentation rate (ESR also called a sedimentation rate, sed rate, or Biernacki Reaction, is the rate at which Red blood cells The mediastinum is a non-delineated group of structures in the Thorax (chest surrounded by Loose connective tissue. )

Treatment

See also: ABVD

Patients with early stage disease (IA or IIA) are effectively treated with radiation therapy or chemotherapy. ABVD is a Chemotherapy regimen used in the first-line treatment of Hodgkin lymphoma. Radiation therapy (or radiotherapy) is the medical use of Ionizing radiation as part of Cancer treatment to control Malignant The choice of treatment depends on the age, sex, bulk and the histological subtype of the disease. Patients with later disease (III, IVA, or IVB) are treated with combination chemotherapy alone. Patients of any stage with a large mass in the chest are usually treated with combined chemotherapy and radiation therapy.

Currently, the ABVD chemotherapy regimen is the gold standard for treatment of Hodgkin's disease. ABVD is a Chemotherapy regimen used in the first-line treatment of Hodgkin lymphoma. Chemotherapy regimens are often identified with acronyms identifying the agents used in combination The abbreviation stands for the four drugs Adriamycin, bleomycin, vinblastine, and dacarbazine. Doxorubicin ( INN,; trade name Adriamycin; also known as hydroxydaunorubicin) is a drug used in cancer Chemotherapy. Bleomycin is a Glycopeptide antibiotic produced by the Bacterium Streptomyces verticillus. Vinblastine is an anti-mitotic drug used to treat certain kinds of Cancer, including Hodgkin's lymphoma, non-small cell Lung cancer Dacarbazine (da-KAR-ba-zeen (brand names DTIC DTIC-Dome also known as DIC or Imidazole Carboxamide is an antineoplastic Chemotherapy drug used in the treatment of various Developed in Italy in the 1970s, the ABVD treatment typically takes between six and eight months, although longer treatments may be required. Another form of treatment is the newer Stanford V regimen, which is typically only half as long as the ABVD but which involves a more intensive chemotherapy schedule and incorporates radiation therapy. Stanford V is a Chemotherapy regimen designed for Hodgkin's lymphoma that consists of the following Mechlorethamine (Sometimes Cyclophosphamide However, in a randomized controlled study, Stanford V was inferior. ^[12]

Another form of treatment, mainly in Europe for stages > II is BEACOPP. BEACOPP is a Chemotherapy regimen for treatment of Hodgkin's lymphoma in Stages > II The cure rate with the BEACOPP esc. regimen is approximately 10-15% higher than with standard ABVD in advanced stages. Although this was shown in a landmark paper in The New England Journal of Medicine (Diehl et al. ), the US physicians still favor ABVD. Probably because some physicians think that BEACOPP induces more secondary leukemia. However, this seems negligible compared to the higher cure rates. Also, BEACOPP is more expensive because of the G-CSF-support that is required. Currently, the German Hodgkin Study group tests 8x BEACOPP esc vs. 6x BEACOPP esc vs. 8x BEACOPP-14 baseline (HD15-trial).

The high cure rates and long survival of many patients with Hodgkin's lymphoma has led to a high concern with late adverse effects of treatment, including cardiovascular disease and second malignancies such as acute leukemias, lymphomas, and solid tumors within the radiation therapy field. Leukemia or leukaemia (Greek leukos λευκός, "white" aima αίμα, "blood" is a Cancer of the Blood Most patients with early stage disease are now treated with abbreviated chemotherapy and involved-field radiation therapy rather than with radiation therapy alone. Clinical research strategies are exploring reduction of the duration of chemotherapy and dose and volume of radiation therapy in an attempt to reduce late morbidity and mortality of treatment while maintaining high cure rates. Hospitals are also treating those who respond quickly to chemo-therapy with no radiation.

Notable cases

• Luke Menard, American Idol Season 7 contestant. The seventh season of American Idol, the annual reality show and singing competition began on January 15, 2008 and concluded Diagnosed with Hodgkin's lymphoma in 2008.
• Mark Fields Former NFL player forced to retire in 2004 from the disease. Mark Fields may refer to Mark Fields (American football (born 1972 American football linebacker Mark Fields (businessman, head of The National Football League ( NFL) is the largest professional American football league.
• Paul Allen, Microsoft co-founder, was diagnosed and treated for Hodgkin's lymphoma in 1983. Paul Gardner Allen (born January 21 1953 is an American computer programmer and entrepreneur who co-founded Microsoft with Bill Gates.
• The actor Richard Harris died of Hodgkin's lymphoma in 2002 after filming Harry Potter and the Chamber of Secrets as main character Albus Dumbledore. Richard St John Harris ( October 1 1930 - October 25 2002) was a two-time Academy Award -nominated and Grammy Award Albus Percival Wulfric Brian Dumbledore
• Former NHL star Mario Lemieux was diagnosed with Hodgkin's lymphoma in January 1993. The National Hockey League ( NHL) is a professional Ice hockey league composed of 30 teams in North America Mario Lemieux (born October 5, 1965 is a retired Canadian professional Ice hockey centre who played 17 seasons for the Pittsburgh Penguins Even after taking 2 months off, Lemieux ended up winning the scoring title that year. The Art Ross Trophy is awarded to the National Hockey League player who leads the league in scoring points at the end of the regular season
• Lynden David Hall died of Hodgkin's lymphoma in 2006. Lynden David Hall ( 7 May 1974 &ndash 14 February 2006) was a singer songwriter arranger
• Barry Watson, an actor who gained fame in the television series 7th Heaven, had successfully treated Hodgkin's lymphoma. Michael Barrett "Barry" Watson (born April 23, 1974) is an American Actor, known for his roles of Matt Camden on 7th Heaven is an Emmy -nominated American drama television series, created and produced by Brenda Hampton
• Delta Goodrem, Australian singer, was diagnosed with Hodgkin's lymphoma in July 2003. Delta Lea Goodrem (born 9 November 1984 is a multi ARIA Award winning Australian Singer-songwriter, Pianist and Logie Award winning
• Former head of NBC Entertainment, Brandon Tartikoff, died in 1997 after a 25 year battle with Hodgkin's disease. The National Broadcasting Company ( NBC) is an American Television network headquartered in the GE Building in New York City's Brandon Tartikoff ( January 13, 1949 &mdash August 27, 1997) was a television executive who was credited with turning around NBC's low
• Senator Arlen Specter (R-PA) was diagnosed with Phase IVB Hodgkin's Disease in 2005, underwent 5 months of chemotherapy, and received a clean bill of health. Arlen Specter (born February 12 1930) is the senior United States Senator from Pennsylvania and a member of the Republican Party On April 15, 2008, he announced that his Hodgkin's had returned. Events 1450 - Battle of Formigny: Toward the end of the Hundred Years' War, the French attack and nearly annihilate English 2008 ( MMVIII) is the current year in accordance with the Gregorian calendar, a Leap year that started on Tuesday of the Common
• British actor Roger Tonge who played the disabled Sandy Richardson in the cult British soap opera Crossroads in the 1960s and 1970s died of Hodgkin's Disease in 1981 at the age of 35. Roger Tonge ( 30 January 1946 - 26 February 1981) was a British Actor. Crossroads is a British Television Soap opera set in a Motel near Birmingham, England.
• Alese Coco one of the most notable non-celebrities to have Hodgkin’s lymphoma. Known worldwide to the Hodgkin’s community as a torch bearer for Hodgkin’s research. Died at the age of 23.
• WWE wrestler Rowdy Roddy Piper was announced to have been diagnosed with Hodgkin's lymphoma on November 27, 2006. World Wrestling Entertainment Inc ( WWE) is a publicly traded privately controlled integrated media (focusing in Television, Internet, Roderick George Toombs (born April 17, 1954) Career After being expelled from junior high and having a falling out with his father Piper hit the Events 1095 - Pope Urban II declares the First Crusade at the Council of Clermont Year 2006 ( MMVI) was a Common year starting on Sunday of the Gregorian calendar.
• John Millington Synge, the Irish author best known for the play The Playboy of the Western World, died in 1909 from the disease. Edmund John Millington Synge ( (16 April 1871 – 24 March 1909 was an Irish Playwright, Poet, Prose writer and collector of Folklore.
• Dinu Lipatti, the Romanian pianist, died of Hodgkin's disease in 1950, 33 years old. Dinu Lipatti ( March 19 1917, Bucharest &ndash December 2 1950, Geneva) was a Romanian classical
• Wayne Shelford, aka 'Buck' Shelford, former All Black rugby player for New Zealand. Wayne Thomas "Buck" Shelford (born 13 December 1957 in Rotorua) is a former Rugby union footballer and coach who represented and captained
• Elizabeth Madox Roberts, a noted Kentucky poet and novelist, died from Hodgkin's in 1941. Elizabeth Madox Roberts ( October 30, 1881 - March 13, 1941) was a Kentucky Novelist and Poet, primarily known
• Joy Hester, a noted Australian artist, died from Hodgkin's in 1960. Joy St Clair Hester ( 21 August 1920 - 4 December 1960) was an Australian artist who lived a tumultuous uncompromising and tragic
• Emma Lazarus, Jewish American poetess, writer of the New Colossus, died of Hodgkin's disease on 19 November 1887. Emma Lazarus ( July 22, 1849 &ndash November 19, 1887) was an American Poet born in New York City. Events 1095 - The Council of Clermont, called by Pope Urban II to discuss sending the First Crusade to the Holy Land Year 1887 ( MDCCCLXXXVII) was a Common year starting on Saturday (link will display the full calendar of the Gregorian calendar (or a Common
• "Mutt" Mantle, Mickey Mantle's dad, died from Hodgkins. Mickey's son Billy also had the disease.
• Martin Fry, vocalist with ABC, was treated for Hodgkin's Disease in 1985/86. Martin Fry (born 9 March, 1958, in Manchester) is lead singer of the band ABC. ABC are an English pop band that charted ten UK and five US Top 40 singles between 1981 and 1990
• James Whitham, motorcycle racer, was treated for Hodgkin's Disease in 1995/96. Michael James 'Jamie' Whitham (born September 6, 1966 in Huddersfield, Yorkshire, England) is a former professional Motorcycle
• Glen Goins, singer and guitarist for Parliament Funkadelic died from Hodgkin's Disease in 1978. --> Glen Lamont Goins (born January 2, 1954, died July 29, 1978) was a singer and guitarist for Parliament Funkadelic The bands Parliament and Funkadelic cannot be easily separated
• Alexander Litvinov, a Russian rock poet and musician, died from Hodgkin's Disease in 1999. Venya Drkin (Веня Д’ркин 11 June 1970 Dolzhansky, Luhansk Oblast, Ukraine - 21 August 1999,
• Jamie Tape AFL Footballer
• Freida Riley, an American schoolteacher who inspired the Rocket Boys, died of Hodgkin's Disease in 1969 at the age of 31. Jamie Tape (5 April 1974 - 3 January 2003 was an Australian rules footballer Football career After amassing an impressive 75 games and winning the 1993 Freida J Riley (1937 &ndash August 5, 1969) was an American science and math Teacher who taught at Big Creek High The movie October Sky was made in honor of her and the Rocket boys.
• Roger Patterson (not the guitarist) who had filmed the famous Patterson-Gimlin film which shows a "female" "Bigfoot" died of the disease still saying the aformentioned film was not a hoax
• Jane Austen, one of the most famous authors of English literature, died in 1817 aged 41. The Patterson-Gimlin film (also referred to as simply the Patterson film) is a short Motion picture of an unidentified subject filmed on The breast is the upper Ventral region of an animal’s Torso, particularly that of Mammals including Human beings. Bigfoot or Sasquatch is alleged to be an Ape -like creature inhabiting remote forests mainly in the Pacific Northwest region of the United States and Canada Jane Austen (16 The cause of death was officially recorded as Addison's disease; however, modern speculation has suggested that it may have been Hodgkin's disease. Addison's disease (also known as chronic Adrenal insufficiency, '''hypocortisolism''' or '''hypocorticism) is a rare Endocrine disorder ^[13]

Cultural references

• A main character in the movie October Sky (and the book Rocket Boys), Miss Riley, was diagnosed with Hodgkin's lymphoma. October Sky is a 1999 film produced by Charles Gordon, starring Jake Gyllenhaal, Chris Cooper and Laura Dern. Rocket Boys (also known as October Sky) is the first Memoir in a series of three by Homer Hickam Jr Freida J Riley (1937 &ndash August 5, 1969) was an American science and math Teacher who taught at Big Creek High
• In the novel Don't Die, My Love, by Lurlene McDaniel, one of the main characters, Luke, is diagnosed with Hodgkin's and dies after about a year and a half. Lurlene McDaniel (born c 1948 is an author who has written over 50 young adult books.
• In the latter part of the television series Party of Five, Charlie Salinger (played by Matthew Fox), was diagnosed with Hodgkin's and, through rigorous regimens and treatments, went into remission. Party of Five is an American Drama Television series that aired on FOX for six seasons from September 12 1994 Matthew Fox may refer to Matthew Fox (actor (born 1966 American actor Matthew Fox (baseball (born 1982 minor league pitcher in
• In Desperate Housewives, the character of Lynette Scavo, (played by Felicity Huffman) is diagnosed with Hodgkin's lymphoma, which she tries to keep a secret. Desperate Housewives is an American Television Dramedy series created by Marc Cherry, who also serves as Show runner, and produced Lynette Scavo ( née Lindquist) is a Fictional character on the ABC television series Desperate Housewives. Felicity Huffman (born December 9, 1962) is an Academy Award -nominated American Actress.
• Bang the Drum Slowly by Mark Harris is a novel about a baseball player's last season when only he and his best friend know he is dying of Hodgkin's disease. The article is about the 1956 novel For the 1973 film adaptation see Bang the Drum Slowly (film Bang the Drum Slowly was Mark Mark Harris ( November 19, 1922 in Mount Vernon New York – May 30, 2007) was an American Novelist literary It was later made into a film of the same name. Bang the Drum Slowly is a 1973 film adaptation of the 1956 baseball novel of the same name by Mark Harris.
• In the television show Curb your Enthusiasm episode "The Five Wood" Larry David believes his friend's father suffered from "the good hodgkin's," and that he learned about it from an episode of Party of Five. Curb Your Enthusiasm is an American Sitcom starring Seinfeld writer co-creator and executive producer Larry David as himself and
• In Jeffrey Archer's "Kane and Abel", Matthew Lester is diagnosed with Hodgkin's, but does not disclose his discovery to anyone. Jeffrey Howard Archer Baron Archer of Weston-super-Mare (born 15 April 1940 is an English Author and former Politician. His best friend, William Kane, is told by Doctor MacKenzie abut the illness shortly before Matthew's death.
• In the 1996 film Infinity (with Matthew Broderick and Patricia Arquette), Arline Greenbaum (Arquette) is suspected of having Hodgkin's lymphoma. Infinity (symbolically represented with ∞) comes from the Latin infinitas or "unboundedness Matthew Broderick (born March 21, 1962) is an American award-winning film and stage Actor who is best known for his roles as the title character Patricia T Arquette (born April 8, 1968) is an American actress. It later turns out to be lymphatic tuberculosis.
• Constable Deirdre 'Dash' McKinley in Australian Police Drama Blue Heelers was diagnosed with Hodgkins and shaved her head to save herself the trauma of going through hair loss. Dash McKinley was a fictional character from Blue Heelers. She entered the series in 1996 and left in 1999 as she resigned from the police force Blue Heelers was a long-running Australian police drama series which depicted the lives of the police officers stationed at the fictional Mt
• Actor DJ Qualls diagnosed with Hodgkin's lymphoma at 14, declared to be in remission after 2 years of treatment at 16

See also

• ABVD
• Stanford V
• Non-Hodgkin lymphoma

References

Headline text

External links

Information

• Hodgkin's Lymphoma at the American National Cancer Institute
• Timeline of discovery and treatment of Hodgkin's Lymphoma
• Lymphomas in Children and Adolescents From the Centre for Cancer and Blood Disorders at Sydney Children's Hospital
• Hodgkin Disease from the Merck Manual
• Photos at Atlas of Pathology
• Anti-Tr antibody

National charities

• Leukaemia CARE (UK)
• Lymphoma Association (UK)
• The Leukemia & Lymphoma Society (US) Information from LLS. The National Cancer Institute (NCI is part of the United States Federal government's National Institutes of Health. Sydney Children's Hospital is an Australian Children's hospital located in the Eastern Suburbs of Sydney, New South Wales. The Merck Manual of Diagnosis and Therapy, often called simply The Merck Manual, is the world's best-selling medical textbook
• Australian Hodgkin's Lymphoma Network (AU)

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