High Desert is a high desert region of the U.S. state of Oregon located in the central and eastern parts of the state. A US state is any one of the fifty subnational entities of the United States of America that share Sovereignty with the federal government Oregon ( is a state in the Pacific Northwest region of the United States. Central Oregon is a geographical region lying near the center of the U Eastern Oregon is the eastern part of the US state of Oregon. It is part of the Great Basin. The Great Basin is a large arid region of the western United States.