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Hook homolog 3 (Drosophila)
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| Identifiers | ||
| Symbol(s) | HOOK3; HK3 | |
| External IDs | OMIM: 607825 MGI: 2443554 HomoloGene: 13022 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 84376 | 320191 |
| Ensembl | ENSG00000168172 | ENSMUSG00000037234 |
| Uniprot | Q86VS8 | Q3UUZ6 |
| Refseq | NM_032410 (mRNA) NP_115786 (protein) |
NM_207659 (mRNA) NP_997542 (protein) |
| Location | Chr 8: 42.87 - 42.99 Mb | Chr 8: 27.5 - 27.58 Mb |
| Pubmed search | [1] | [2] |
Hook homolog 3 (Drosophila), also known as HOOK3, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment. [supplied by OMIM][1]
References
Further reading
- Krämer H, Phistry M (1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila. ". Genetics 151 (2): 675–84. PMID 9927460.
- Walenta JH, Didier AJ, Liu X, Krämer H (2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. ". J. Cell Biol. 152 (5): 923–34. PMID 11238449.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Shotland Y, Krämer H, Groisman EA (2003). "The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking. ". Mol. Microbiol. 49 (6): 1565–76. PMID 12950921.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Kaiser F, Kaufmann SH, Zerrahn J (2004). "IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3. ". J. Cell. Sci. 117 (Pt 9): 1747–56. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15075236.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1. ". Traffic 6 (6): 442–58. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15882442.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization. ". Nat. Biotechnol. 24 (10): 1285–92. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16964243.
- Sano H, Ishino M, Krämer H, et al. (2007). "The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. ". J. Biol. Chem. 282 (11): 7973–81. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17237231.
- Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, et al. (2007). "HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma. ". Endocr. Relat. Cancer 14 (2): 445–52. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17639057.