HMB-45 is a monoclonal antibody that reacts against an antigen present in melanocytic tumors such as melanomas. Monoclonal antibodies ( mAb or moAb) are monospecific antibodies that are identical because they are produced by one type of immune cell Melanocytes are cells located in the bottom layer (the Stratum basale) of the skin's epidermis and in the middle layer of the eye (the Uvea) See also Cancer A tumor or tumour is the name for a swelling or lesion formed by an abnormal growth of cells (termed neoplastic Melanoma is a Malignant Tumor of Melanocytes which are found predominantly in skin but also in the Bowel and the Eye (see It is used in anatomic pathology as a marker for such tumors. Pathology; please do not remove --> (
HMB-45 was discovered by Drs. Allen M. Gown and Arthur M. Vogel in 1986. Year 1986 ( MCMLXXXVI) was a Common year starting on Wednesday (link displays 1986 Gregorian calendar) [1] The antibody was generated to an extract of melanoma. It reacted positively against melanocytic tumors but not other tumors, thus demonstrating specificity and sensitivity. Moreover, the antibody reacts positively against junctional nevus cells but not intradermal nevi, and against fetal melanocytes but not normal adult melanocytes. Nevus (or naevus, plural nevi, from nævus, Latin for birthmark is the medical term for sharply-circumscribed and Chronic lesions of the HMB stands for Human Melanoma Black.
References
- ^ Gown AM, Vogel AM, Hoak D, Gough F, McNutt MA (1986). "Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes". Am. J. Pathol. 123 (2): 195–203. PMID 3518473.
External links
- Melanoma Marker (HMB45) Antibody - www. scbt. com
- Melanoma antibody (ab787) datasheet - abcam. com.
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