The title Guy I may refer to:
- Guy I of Jebail, of the Embriaco family
- Guy I de la Roche (1205-1263), Duke of Athens
- Guy I of Montlhéry (d. The Embriaco family were Genoese Adventurers who played an important part in the history of the Crusader states. Guy I de la Roche (1205-1263 was the Duke of Athens (from 1225 the nephew and successor of the first duke Otto. Guy I (died 1095 was the second lord of Bray and the second lord of Montlhéry. 1095)
- Guy I of Ponthieu (d. Guy I of Ponthieu (died 13 October 1100) was born sometime in the mid to late 1020s 1100)
- Guy I of Spoleto (d. Guy I (d860 was the Duke of Spoleto from 842 He was the son of Lambert I of Nantes and Adelaide of Lombardy the eldest daughter of Pepin of Italy. 860)
- Guy I, Count of Blois (d. Guy I of Blois-Châtillon (died August 12, 1342) son of Hugh II of Châtillon and Beatrix of Dampierre was Count of Blois and lord of 1342)
- Guy I of Albon
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