In organometallic chemistry, the Green-Davies-Mingos Rules predict the regiochemistry for nucleophilic addition to 18-electron metal complexes containing multiple unsaturated ligands. Organometallic chemistry is the study of Chemical compounds containing bonds between Carbon and a Metal. In Organic chemistry, a nucleophilic addition reaction is an Addition reaction where in a Chemical compound a π bond is removed by the creation The term complex in Chemistry is usually used to describe molecules or ensembles formed by the combination of Ligands and metal Ions. In Chemistry, a ligand is either an Atom, Ion, or Molecule (see also Functional group) that bonds to a central metal generally [1] In general, complexation enhances the susceptibility of unsaturated hydrocarbon toward nucleophilic attack. In Chemistry, a nucleophile (literally nucleus lover as in nucleus and phile) is a Reagent that forms a Chemical bond to
- Rule 1. Nucleophilic attack is preferred on even-numbered polyenes (even hapticity).
- Rule 2. Nucleophiles preferentially add to acyclic polyenes vs closed polyenes. Acyclic polyenes include polyenes.
- Rule 3A. Even acyclic polyene ligands add nucleophiles at a terminal position.
- Rule 3B. Even acyclic polyene ligands add nucleophiles at the terminal carbon occurs only for highly electrophilic metals, otherwise attack occurs at an internal site.
References
- ^ Davies, M. L. H. Green, and D. M. P. Mingos. “Nucleophilic addition to organotransition metal cations containing unsaturated hydrocarbon ligands. ” Tetrahedron (1978), 34, 3047-3077.
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