In pathology, grading is a measure of the progress of tumors and other neoplasms. Pathology (from Greek grc πάθος pathos, "fate harm" and grc -λογία -logia) is the study and See also Cancer A tumor or tumour is the name for a swelling or lesion formed by an abnormal growth of cells (termed neoplastic Some pathology grading systems apply only to malignant neoplasms (cancer); others apply also to benign neoplasms. Malignant (from the Latin roots mal- = "bad" and -genus = "born" is a medical term used to describe a severe and progressively worsening disease Cancer (medical term Malignant Neoplasm) is a class of Diseases in which a group of cells display uncontrolled
Pathology grading systems are used to classify neoplasms in terms of how abnormal the cells appear microscopically and what may be the outcome in terms of rate of growth, invasiveness, and dissemination. Cancer is a disorder of excessive cell growth, hence cancer cells often are poorly differentiated. The grade reflects the degree of cellular differentiation and refers to how much the tumor cells resemble or differ from the normal cells of the same tissue type.
An important part of evaluating a cancer is to determine its histologic grade. Histology (from the Greek = 'tissue' is the study of the microscopic anatomy of cells and tissues of Plants and Grade is a marker of how differentiated a cell is. Grade is rated numerically (Grade 1-4) or descriptively (e. g. , "high grade" or "low grade"). The higher the numeric grade, the more "poorly differentiated" is the cell, and it is called "high grade". A low grade cancer has a low number and is "well-differentiated. " Grade is most commonly given on a three-tier scale. A cancer that is very poorly differentiated is called anaplastic. Hyperplasia Hypertrophy Carcinoma Sarcoma Hyperplasia an increase in the number of cells in an organ or tissue which usually leads to an increase in the size of the tissue or organ Hypertrophy Tumors may be graded on four-tier, three-tier, or two-tier scales, depending on the institution and the tumor type.
The most commonly used system of grading is as per the guidelines of the American Joint Commission on Cancer. As per their standards, the following are the grading categories.
- GX Grade cannot be assessed
- G1 Well differentiated (Low grade)
- G2 Moderately differentiated (Intermediate grade)
- G3 Poorly differentiated (High grade)
- G4 Undifferentiated (High grade)
Grading systems are also different for each type of cancer.
The Gleason system used to grade the adenocarcinoma cells in prostate cancer is the most famous. This system uses a grading score ranging from 2 to 10. Lower Gleason scores describe well-differentiated less aggressive tumours. Other systems include the Bloom-Richardson system (breast cancer) and the Fuhrman system (kidney cancer).
The tumor grade, along with the staging, is used to develop an individual treatment plan and to predict the patient's prognosis.
Examples of grading schemes
| Grade 1 | Low grade | Well-differentiated |
| Grade 2 | Intermediate grade | Moderately-differentiated |
| Grade 3 | High grade | Poorly-differentiated |
| Grade 4 | Anaplastic | Anaplastic |
| Grade 1 | Low grade | Well-differentiated |
| Grade 2 | Intermediate grade | |
| Grade 3 | High grade | Poorly-differentiated |
| Grade 1 | Low grade | Well-differentiated |
| Grade 2 | High grade | Poorly-differentiated |
See also
- TNM#Other parameters
- Tumor kinds that have their own grading system:
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