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Glucose phosphate isomerase

Enzyme Glucose-6-phosphate isomerase
PDB Code PDB 1GZV
Organism Pig
Tissue Muscle
Complexed molecules 5-phosphoarabinoate
Symbol(s): GPI
Genetic data
Locus: Chr. 19 q13.1
Database Links
EC number: 5.3.1.9
Entrez: 2821
OMIM: 172400
RefSeq: NM_000175
UniProt: P06744

Glucose-6-phosphate isomerase, or phosphoglucose isomerase, is an enzyme (EC 5.3.1.9) that catalyzes the conversion of glucose-6-phosphate into fructose-6-phosphate in the second step of glycolysis. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography Pigs, also called hogs or' swine', are Ungulates which have been domesticated as sources of food leather and similar products since ancient times Muscle (from Latin musculus, diminutive of mus "mouse" is contractile tissue of the body and is derived from the The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome Genetics (from Ancient Greek grc-Latn genetikos, “genitive” and that from grc-Latn genesis, “origin” a discipline of Biology, is In the fields of Genetics and Evolutionary computation, a locus (plural loci) is a fixed position on a Chromosome such as the position of a Chromosome 19 is one of the 23 pairs of Chromosomes in Humans People normally have two copies of this chromosome This article is about the Enzyme Commission codes For the European Commission system for coding chemicals see EC-No. The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences The Mendelian Inheritance in Man project is a Database that catalogues all the known Diseases with a genetic component, and—when possible—links them The National Center for Biotechnology Information ( NCBI) is part of the United States National Library of Medicine (NLM a branch of the National Institutes Swiss-Prot is a manually curated Biological database of Protein sequences Enzymes are Biomolecules that catalyze ( ie increase the rates of Chemical reactions Almost all enzymes are Proteins This article is about the Enzyme Commission codes For the European Commission system for coding chemicals see EC-No. Glucose 6-phosphate (also known as Robison ester) is Glucose sugar Phosphorylated on carbon 6 Fructose 6-phosphate (also known as the Neuberg ester) is Fructose sugar Phosphorylated on carbon 6 (ie See also Gluconeogenesis, which carries out a process wherein glucose is synthesized rather than catabolized An unrelated enzyme, D-xylose isomerase (EC 5.3.1.5) catalyzes the isomerization of glucose to fructose, and is sometimes called "glucose isomerase". This article is about the Enzyme Commission codes For the European Commission system for coding chemicals see EC-No. Glucose (Glc a Monosaccharide (or simple Sugar) also known as grape sugar, is an important Carbohydrate in Biology. Fructose (also levulose or laevulose) is a simple reducing Sugar ( Monosaccharide) found in many foods and is one of the three

The human variant of this enzyme is encoded by the GPI gene. Glucose phosphate isomerase, also known as GPI, is a human Protein encoded by the Gene. History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance

In glycolysis

α-D-Glucose 6-phosphate Phosphoglucose isomerase β-D-Fructose 6-phosphate
image:Glucose-6-phosphate_wpmp.png   image:Fructose-6-phosphate_wpmp.png
 
  Phosphoglucose isomerase

Compound C00668 at KEGG Pathway Database. Glucose 6-phosphate (also known as Robison ester) is Glucose sugar Phosphorylated on carbon 6 Glucose-6-phosphate isomerase, or phosphoglucose isomerase, is an Enzyme ( that catalyzes the conversion of Glucose-6-phosphate into Fructose-6-phosphate Fructose 6-phosphate (also known as the Neuberg ester) is Fructose sugar Phosphorylated on carbon 6 (ie Glucose-6-phosphate isomerase, or phosphoglucose isomerase, is an Enzyme ( that catalyzes the conversion of Glucose-6-phosphate into Fructose-6-phosphate KEGG ( Kyoto Encyclopedia of Genes and Genomes) is a collection of Online databases dealing with Genomes Enzymatic pathways and biological chemicals Enzyme 5.3.1.9 at KEGG Pathway Database. KEGG ( Kyoto Encyclopedia of Genes and Genomes) is a collection of Online databases dealing with Genomes Enzymatic pathways and biological chemicals Compound C05345 at KEGG Pathway Database. KEGG ( Kyoto Encyclopedia of Genes and Genomes) is a collection of Online databases dealing with Genomes Enzymatic pathways and biological chemicals Reaction R00771 at KEGG Pathway Database. KEGG ( Kyoto Encyclopedia of Genes and Genomes) is a collection of Online databases dealing with Genomes Enzymatic pathways and biological chemicals

As a glucose isomerase

D-Glucose Phosphoglucose isomerase D-Fructose
image:D-glucose_wpmp.png   Image:D-fructose wpmp.png
 
  Phosphoglucose isomerase

Other functions

There is evidence that phosphoglucose isomerase acts as a molecular messenger. Glucose (Glc a Monosaccharide (or simple Sugar) also known as grape sugar, is an important Carbohydrate in Biology. Glucose-6-phosphate isomerase, or phosphoglucose isomerase, is an Enzyme ( that catalyzes the conversion of Glucose-6-phosphate into Fructose-6-phosphate Fructose (also levulose or laevulose) is a simple reducing Sugar ( Monosaccharide) found in many foods and is one of the three Glucose-6-phosphate isomerase, or phosphoglucose isomerase, is an Enzyme ( that catalyzes the conversion of Glucose-6-phosphate into Fructose-6-phosphate It is produced and secreted by white blood cells, and acts to regulate the growth of several different cell types.

 v  d  e 
Glycolysis Metabolic Pathway
Glucose Hexokinase Glucose-6-phosphate Glucose-6-phosphate isomerase Fructose 6-phosphate 6-phosphofructokinase Fructose 1,6-bisphosphate Fructose bisphosphate aldolase Dihydroxyacetone phosphate Glyceraldehyde 3-phosphate Triosephosphate isomerase Glyceraldehyde 3-phosphate Glyceraldehyde-3-phosphate dehydrogenase
ATP ADP ATP ADP NAD+ + Pi NADH + H+
+ 2
NAD+ + Pi NADH + H+
1,3-Bisphosphoglycerate Phosphoglycerate kinase 3-Phosphoglycerate Phosphoglycerate mutase 2-Phosphoglycerate Phosphopyruvate hydratase(Enolase) Phosphoenolpyruvate Pyruvate kinase Pyruvate Pyruvate dehydrogenase Acetyl-CoA
ADP ATP H2O ADP ATP CoA + NAD+ NADH + H+ + CO2
2 2 2 2 2 2
ADP ATP H2O
See also Gluconeogenesis, which carries out a process wherein glucose is synthesized rather than catabolized In Biochemistry, a metabolic pathway is a series of chemical reactions occurring within a cell. Glucose (Glc a Monosaccharide (or simple Sugar) also known as grape sugar, is an important Carbohydrate in Biology. Variation across species Hexokinases have been found in every organism checked ranging from bacteria, Yeast, and Plants to humans and other Vertebrates Glucose 6-phosphate (also known as Robison ester) is Glucose sugar Phosphorylated on carbon 6 Fructose 6-phosphate (also known as the Neuberg ester) is Fructose sugar Phosphorylated on carbon 6 (ie Phosphofructokinase-1 (PFK-1 is the most important regulatory Enzyme ( of Glycolysis. Fructose 16-phosphate is Fructose sugar Phosphorylated on carbons 1 and 6 (ie Aldolase A is an Enzyme which catalyses one of the Aldol reactions: The substrate, Fructose 16-bisphosphate (F-16-BP is broken down into Dihydroxyacetone phosphate (DHAP is a biochemical compound involved in many reactions from the Calvin cycle in plants to the ether-lipid biosynthesis process in Leishmania Glyceraldehyde 3-phosphate, also known as triose phosphate or 3-phosphoglyceraldehyde and abbreviated as G3P, GADP, GAP or PGAL Triose-phosphate isomerase (TPI or TIM is an Enzyme ( that catalyzes the reversible interconversion of the Triose phosphate Isomers Glyceraldehyde 3-phosphate, also known as triose phosphate or 3-phosphoglyceraldehyde and abbreviated as G3P, GADP, GAP or PGAL Glyceraldehyde 3-phosphate dehydrogenase (abbreviated as GAPDH or less commonly as G3PDH ( is an Enzyme that catalyzes the sixth step of Overview Phosphoglycerate mutase (PGM is an Enzyme that catalyzes step 8 of Glycolysis. In Enzymology, a phosphopyruvate hydratase ( is an Enzyme that catalyzes the Chemical reaction 2-phospho-D-glycerate \rightleftharpoons Enolase also known as phosphopyruvate dehydratase is a Metalloenzyme responsible for the catalysis of 2-phosphoglycerate (2-PG to Phosphoenolpyruvate (PEP Phosphoenolpyruvate (synonyms phosphoenolpyruvic acid, PEP) is an important Chemical compound in Biochemistry. Reaction The reaction with pyruvate kinase pyruvate kinase PEP ----------> pyruvate / \ ADP ATP Pyruvic acid (CH3COCO2H is an alpha-keto acid. The Carboxylate Anion of pyruvic acid is known as pyruvate. Pyruvate dehydrogenase (E1 is the first component Enzyme of Pyruvate dehydrogenase complex (PDC Acetyl-CoA is an important molecule in metabolism used in many biochemical reactions Coenzyme A ( CoA, CoASH, or HSCoA) is a Coenzyme, notable for its role in the synthesis and oxidation of Fatty acids
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