In enzymology, a glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) is an enzyme that catalyzes the chemical reaction
- dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-glucose
Thus, the two substrates of this enzyme are dTTP and alpha-D-glucose 1-phosphate, whereas its two products are diphosphate and dTDP-glucose. Enzymes are Biomolecules that catalyze ( ie increase the rates of Chemical reactions Almost all enzymes are Proteins This article is about the Enzyme Commission codes For the European Commission system for coding chemicals see EC-No. Enzymes are Biomolecules that catalyze ( ie increase the rates of Chemical reactions Almost all enzymes are Proteins Catalysis is the process in which the rate of a Chemical reaction is increased by means of a Chemical substance known as a catalyst A chemical reaction is a process that always results in the interconversion of Chemical substances The substance or substances initially involved in a chemical reaction are called A product is a substance that forms as a result of a Biological - or Chemical reaction. In Chemistry, the Anion, the Salts and the Esters of Pyrophosphoric acid are called pyrophosphates.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). In Biochemistry, a transferase is an Enzyme that catalyzes the transfer of a Functional group (e Nucleotides are Organic compounds that consist of three joined structures a nitrogenous base a Sugar, and a Phosphate group Nucleotidyltransferases are Phosphotransferase enzymes which act upon components of Nucleotides They are classified under EC number 2 The systematic name of this enzyme class is dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase. Other names in common use include glucose 1-phosphate thymidylyltransferase, dTDP-glucose synthase, dTDP-glucose pyrophosphorylase, thymidine diphosphoglucose pyrophosphorylase, thymidine diphosphate glucose pyrophosphorylase, and TDP-glucose pyrophosphorylase. This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis. Metabolism is the set of Chemical reactions that occur in living Organisms in order to maintain Life. In nucleotide sugar metabolism a group of Biochemicals known as Nucleotide sugars act as donors for sugar residues in the Glycosylation reactions that produce
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Structural studies
As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1FXO, 1FZW, 1G0R, 1G1L, 1G23, 1G2V, 1G3L, 1H5R, 1H5S, 1H5T, 1IIM, 1IIN, 1LVW, 1MC3, 1MP3, 1MP4, 1MP5, 2GGO, and 2GGQ. In Biochemistry and Chemistry, the tertiary structure of a Protein or any other Macromolecule is its three-dimensional structure as defined The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography
References
- IUBMB entry for 2.7.7.24
- BRENDA references for 2.7.7.24 (Recommended. )
- PubMed references for 2.7.7.24
- PubMed Central references for 2.7.7.24
- Google Scholar references for 2.7.7.24
- Kornfeld S and Glaser L (1961). "The enzymic synthesis of thymidine-linked sugars. I. Thymidine diphosphate glucose". J. Biol. Chem. 236: 1791–1794.
- Pazur JH and Shuey EW (1961). "The enzymatic synthesis of thymidine diphosphate glucose and its conversion to thymidine diphosphate rhamnose". J. Biol. Chem. 236: 1780–1785.
External links
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- The CAS registry number for this enzyme class is 9026-03-3. CAS registry numbers are unique numerical identifiers for Chemical compounds Polymers biological sequences mixtures and Alloys They are also referred to