Ghon's complex, sometimes called Ranke's complex is a lesion seen in the lung that is caused by tuberculosis. Tuberculosis (abbreviated as TB for tubercle bacillus or T u' b' erculosis Bacillus --> is a common The two alternative names come from the scientists Karl Ernst Ranke, or Anton Ghon, respectively. [1][2] The lesions consist of a calcified focus of infection and an associated lymph node. Calcification is the process in which the mineral calcium builds up in soft tissue causing it to harden A Lymph node ( lɪmf noʊd is an organ consisting of many types of cells and is a part of the Lymphatic system. These lesions are particularly common in children and can retain viable bacteria, so are sources of long-term infection and may be involved in reactivation of the disease in later life. [3]
Specifically, the Ghon's complex is a combination of the Ghon's focus (area of initial infection by airborne bacillus) and a lymphatic lesion. A Ghon focus is a primary lesion caused by mycobacterium Bacilli ( Tuberculosis) developed in the lung of a previously uninfected individual The lymphatic system in Vertebrates is a network of conduits that carry a clear fluid called Lymph. Approximately two to three weeks after the Ghon's focus has developed, the area undergoes caseous necrosis (cheeselike). Caseous necrosis describes a form of Biological tissue death caseous meaning it has a cheese-like appearance Free tubercle bacilli, or bacilli within macrophages drain out from the area towards the affected lungs' lymph nodes. It is in this location, at the lymph nodes, that the bacilli will form caseous granulomas. This, in combination with the initial area of infection, will make up the Ghon's complex. Typically these areas heal with calcification visible on chest X-ray, with the two causes virtually indistinguishable.
See also
References
- ^ Ghon's primary lesion Whonamedit. A Ghon focus is a primary lesion caused by mycobacterium Bacilli ( Tuberculosis) developed in the lung of a previously uninfected individual com, Accessed 21 January 2008
- ^ Ober WB (1983). "Ghon but not forgotten: Anton Ghon and his complex". Pathol Annu 18 Pt 2: 79–85. PMID 6371678.
- ^ Curvo-Semedo L, Teixeira L, Caseiro-Alves F (2005). "Tuberculosis of the chest". Eur J Radiol 55 (2): 158–72. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15905057.
- Porth, Carol Mattson. Pathophysiology: Concepts of Altered Health States, 7th edition. Philadelphia: Lippincott Williams & Wilkins, 2005.
Dapyx Software network: MP3 Explorer | Ebook Manager | Zenithic