Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
PDB rendering based on 1fq3. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography
Available structures: 1fq3, 1iau
Identifiers
Symbol(s)	GZMB; HLP; CTLA1; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTSGL1; SECT
External IDs	OMIM: 123910 MGI: 109267 HomoloGene: 20876
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3002	14939
Ensembl	ENSG00000100453	ENSMUSG00000015437
Uniprot	P10144	Q3TIP3
Refseq	NM_004131 (mRNA) NP_004122 (protein)	NM_013542 (mRNA) NP_038570 (protein)
Location	Chr 14: 24.17 - 24.17 Mb	Chr 14: 55.21 - 55.22 Mb
Pubmed search	[1]	[2]

Granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1), also known as GZMB, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response. ^[1]

See also

• Granzyme

References

Further reading