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G protein pathway suppressor 2
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| Identifiers | ||
| Symbol(s) | GPS2; AMF-1; MGC104294; MGC119287; MGC119288; MGC119289 | |
| External IDs | OMIM: 601935 MGI: 1891751 HomoloGene: 49599 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 2874 | 56310
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| Refseq | NM_004489 (mRNA) NP_004480 (protein) |
NM_019726 (mRNA) NP_062700 (protein) |
| Pubmed search | [1] | [2] |
G protein pathway suppressor 2, also known as GPS2, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [1]
References
Further reading
- Spain BH, Bowdish KS, Pacal AR, et al. (1997). "Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. ". Mol. Cell. Biol. 16 (12): 6698–706. PMID 8943324.
- Jin DY, Teramoto H, Giam CZ, et al. (1997). "A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha. ". J. Biol. Chem. 272 (41): 25816–23. PMID 9325311.
- Peng YC, Breiding DE, Sverdrup F, et al. (2000). "AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins. ". J. Virol. 74 (13): 5872–9. PMID 10846067.
- Degenhardt YY, Silverstein SJ (2001). "Gps2, a protein partner for human papillomavirus E6 proteins. ". J. Virol. 75 (1): 151–60. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11119584.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. ". Genome Res. 11 (3): 422–35. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11230166.
- Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. ". DNA Res. 8 (2): 85–95. PMID 11347906.
- Peng YC, Kuo F, Breiding DE, et al. (2001). "AMF1 (GPS2) modulates p53 transactivation. ". Mol. Cell. Biol. 21 (17): 5913–24. PMID 11486030.
- Zhang J, Kalkum M, Chait BT, Roeder RG (2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. ". Mol. Cell 9 (3): 611–23. PMID 11931768.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Yoon HG, Chan DW, Huang ZQ, et al. (2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. ". EMBO J. 22 (6): 1336–46. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12628926.
- Yoon HG, Chan DW, Reynolds AB, et al. (2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. ". Mol. Cell 12 (3): 723–34. PMID 14527417.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Diederichs S, Bäumer N, Ji P, et al. (2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. ". J. Biol. Chem. 279 (32): 33727–41. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15159402.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Lee TH, Yi W, Griswold MD, et al. (2006). "Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment. ". DNA Repair (Amst. ) 5 (1): 32–42. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16122992.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome. ". Cell 122 (6): 957–68. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16169070.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network. ". Nature 437 (7062): 1173–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16189514.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry. ". Mol. Syst. Biol. 3: 89. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17353931.
- Sanyal S, Båvner A, Haroniti A, et al. (2007). "Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis. ". Proc. Natl. Acad. Sci. U. S. A. 104 (40): 15665–70. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17895379.
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