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G protein-coupled receptor 45
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| Identifiers | ||
| Symbol(s) | GPR45; PSP24; PSP24(ALPHA); PSP24A | |
| External IDs | OMIM: 604838 MGI: 2135882 HomoloGene: 5228 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 11250 | 93690 |
| Ensembl | ENSG00000135973 | ENSMUSG00000041907 |
| Uniprot | Q9Y5Y3 | Q148B5 |
| Refseq | NM_007227 (mRNA) NP_009158 (protein) |
NM_053107 (mRNA) NP_444337 (protein) |
| Location | Chr 2: 105.22 - 105.23 Mb | Chr 1: 42.9 - 42.98 Mb |
| Pubmed search | [1] | [2] |
G protein-coupled receptor 45, also known as GPR45, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
This intronless gene encodes a member of the G protein-coupled receptor (GPCR) family. Members of this protein family contain seven putative transmembrane domains and may mediate signaling processes to the interior of the cell via activation of heterotrimeric G proteins. This protein may function in the central nervous system. [1]
References
Further reading
- Marchese A, Sawzdargo M, Nguyen T, et al. (1999). "Discovery of three novel orphan G-protein-coupled receptors. ". Genomics 56 (1): 12-21. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 10036181.
- Kawasawa Y, Kume K, Nakade S, et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. ". Biochem. Biophys. Res. Commun. 276 (3): 952-6. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11027574.
- Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems. ". Biochem. Biophys. Res. Commun. 276 (3): 957-64. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11027575.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ". Nature 434 (7034): 724-31. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15815621.