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Golgi autoantigen, golgin subfamily a, 4
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| PDB rendering based on 1r4a. The Protein Data Bank ( PDB) is a repository for 3-D structural data of Proteins and Nucleic acids These data typically obtained by X-ray crystallography | ||
| Available structures: 1r4a, 1upt | ||
| Identifiers | ||
| Symbol(s) | GOLGA4; GCP2; GOLG; MU-RMS-40. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome 18; p230 | |
| External IDs | OMIM: 602509 MGI: 1859646 HomoloGene: 68224 | |
| Orthologs | ||
| Human | Mouse | |
| Entrez | 2803 | 54214 |
| Ensembl | ENSG00000144674 | ENSMUSG00000038708 |
| Uniprot | Q13439 | Q3UYD1 |
| Refseq | NM_002078 (mRNA) NP_002069 (protein) |
NM_018748 (mRNA) NP_061218 (protein) |
| Location | Chr 3: 37.26 - 37.38 Mb | Chr 9: 118.35 - 118.44 Mb |
| Pubmed search | [1] | [2] |
Golgi autoantigen, golgin subfamily a, 4, also known as GOLGA4, is a human gene. The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternative splice variants have been described but their full-length nature has not been determined. [1]
References
Further reading
- Kooy J, Toh BH, Pettitt JM, et al. (1992). "Human autoantibodies as reagents to conserved Golgi components. Characterization of a peripheral, 230-kDa compartment-specific Golgi protein. ". J. Biol. Chem. 267 (28): 20255–63. PMID 1400343.
- Fritzler MJ, Lung CC, Hamel JC, et al. (1996). "Molecular characterization of Golgin-245, a novel Golgi complex protein containing a granin signature. ". J. Biol. Chem. 270 (52): 31262–8. PMID 8537393.
- Erlich R, Gleeson PA, Campbell P, et al. (1996). "Molecular characterization of trans-Golgi p230. A human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif. ". J. Biol. Chem. 271 (14): 8328–37. PMID 8626529.
- Gleeson PA, Anderson TJ, Stow JL, et al. (1997). "p230 is associated with vesicles budding from the trans-Golgi network. ". J. Cell. Sci. 109 ( Pt 12): 2811–21. PMID 9013329.
- Barr FA (1999). "A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins. ". Curr. Biol. 9 (7): 381–4. PMID 10209123.
- Daigo Y, Isomura M, Nishiwaki T, et al. (1999). "Characterization of a 1200-kb genomic segment of chromosome 3p22-p21. 3. ". DNA Res. 6 (1): 37–44. PMID 10231028.
- Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens. ". Proc. Natl. Acad. Sci. U. S. A. 98 (2): 629–34. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11149944.
- Van Valkenburgh H, Shern JF, Sharer JD, et al. (2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. ". J. Biol. Chem. 276 (25): 22826–37. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 11303027.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Lu L, Hong W (2004). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi. ". Mol. Biol. Cell 14 (9): 3767–81. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12972563.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources. ". Mol. Cell Proteomics 3 (4): 311–26. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14718574.
- Wu M, Lu L, Hong W, Song H (2004). "Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1. ". Nat. Struct. Mol. Biol. 11 (1): 86–94. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14718928.
- Kakinuma T, Ichikawa H, Tsukada Y, et al. (2004). "Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery. ". Exp. Cell Res. 298 (2): 388–98. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15265687.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins. ". Proc. Natl. Acad. Sci. U. S. A. 101 (33): 12130–5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15302935.
- Luke MR, Houghton F, Perugini MA, Gleeson PA (2005). "The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers. ". Biochem. J. 388 (Pt 3): 835–41. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15654769.
- Yoshino A, Setty SR, Poynton C, et al. (2006). "tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre. ". J. Cell. Sci. 118 (Pt 10): 2279–93. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15870108.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. ". Cell 127 (3): 635–48. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17081983.
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