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Golgi autoantigen, golgin subfamily a, 1
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| Identifiers | ||
| Symbol(s) | GOLGA1; MGC33154; golgin-97 | |
| External IDs | OMIM: 602502 MGI: 1924149 HomoloGene: 68223 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 2800 | 76899 |
| Ensembl | ENSG00000136935 | ENSMUSG00000026754 |
| Uniprot | Q92805 | Q05CJ8 |
| Refseq | NM_002077 (mRNA) NP_002068 (protein) |
NM_029793 (mRNA) NP_084069 (protein) |
| Location | Chr 9: 126.68 - 126.74 Mb | Chr 2: 38.84 - 38.89 Mb |
| Pubmed search | [1] | [2] |
Golgi autoantigen, golgin subfamily a, 1, also known as GOLGA1, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent UniProt is the uni versal prot ein resource a central repository of Protein data created by combining Swiss-Prot, TrEMBL PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This encoded protein is associated with Sjogren's syndrome. [1]
References
Further reading
- Griffith KJ, Chan EK, Lung CC, et al. (1997). "Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjögren's syndrome. ". Arthritis Rheum. 40 (9): 1693-702. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 9324025.
- Barr FA (1999). "A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins. ". Curr. Biol. 9 (7): 381-4. PMID 10209123.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899-903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- Lu L, Hong W (2004). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi. ". Mol. Biol. Cell 14 (9): 3767-81. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12972563.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs. ". Nat. Genet. 36 (1): 40-5. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 14702039.
- Lu L, Tai G, Hong W (2005). "Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network. ". Mol. Biol. Cell 15 (10): 4426-43. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15269279.
- Luke MR, Houghton F, Perugini MA, Gleeson PA (2005). "The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers. ". Biochem. J. 388 (Pt 3): 835-41. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15654769.
- Lock JG, Hammond LA, Houghton F, et al. (2006). "E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by golgin-97. ". Traffic 6 (12): 1142-56. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 16262725.
- Alzhanova D, Hruby DE (2007). "A host cell membrane protein, golgin-97, is essential for poxvirus morphogenesis. ". Virology 362 (2): 421-7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 17276477.
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