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Glycine-N-acyltransferase
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| Identifiers | ||
| Symbol(s) | GLYAT; CAT; ACGNAT; GAT | |
| External IDs | OMIM: 607424 MGI: 2147502 HomoloGene: 64840 | |
| RNA expression pattern | ||
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| Orthologs | ||
| Human | Mouse | |
| Entrez | 10249 | 107146 |
| Ensembl | ENSG00000149124 | ENSMUSG00000063683 |
| Refseq | NM_005838 (mRNA) NP_005829 (protein) |
NM_145935 (mRNA) NP_666047 (protein) |
| Location | Chr 11: 58.23 - 58.26 Mb | Chr 19: 12.7 - 12.72 Mb |
| Pubmed search | [1] | [2] |
Glycine-N-acyltransferase, also known as GLYAT, is a human gene. The Human Genome Organisation (HUGO is an organization involved in the Human Genome Project, a project about mapping the human genome The Mouse Genome Informatics (MGI website is run by The Jackson Laboratory. HomoloGene, a tool of the National Center for Biotechnology Information (NCBI is a system for automated detection of homologs (similarity attributable to descent The Entrez Global Query Cross-Database Search System is a powerful Federated search engine or Web portal that allows users to search many discrete Health sciences Ensembl is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent PubMed is a free search engine for accessing the MEDLINE database of citations and abstracts of biomedical research articles History See also History of genetics The existence of genes was first suggested by Gregor Mendel (1822-1884 who in the 1860s studied inheritance [1]
The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [1]
References
Further reading
- Webster LT, Siddiqui UA, Lucas SV, et al. (1976). "Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man. ". J. Biol. Chem. 251 (11): 3352–8. PMID 931988.
- Mawal YR, Qureshi IA (1995). "Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver. ". Biochem. Biophys. Res. Commun. 205 (2): 1373–9. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 7802672.
- Mawal YR, Qureshi IA (1995). "An immunodetection method for the quantitation of human acyl CoA:glycine N-acyltransferase in biological samples. ". Biochem. Mol. Biol. Int. 34 (3): 595–601. PMID 7833837.
- Merkler DJ, Merkler KA, Stern W, Fleming FF (1996). "Fatty acid amide biosynthesis: a possible new role for peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine N-acyltransferase. ". Arch. Biochem. Biophys. 330 (2): 430–4. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 8660675.
- Mawal Y, Paradis K, Qureshi IA (1997). "Developmental profile of mitochondrial glycine N-acyltransferase in human liver. ". J. Pediatr. 130 (6): 1003–7. PMID 9202629.
- van der Westhuizen FH, Pretorius PJ, Erasmus E (2000). "The utilization of alanine, glutamic acid, and serine as amino acid substrates for glycine N-acyltransferase. ". J. Biochem. Mol. Toxicol. 14 (2): 102–9. PMID 10630424.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ". Proc. Natl. Acad. Sci. U. S. A. 99 (26): 16899–903. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 12477932.
- SCHACHTER D, TAGGART JV (2003). "Glycine N-acylase: purification and properties. ". J. Biol. Chem. 208 (1): 263–75. PMID 13174534.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. ". Genome Res. 14 (9): 1711–8. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ". Genome Res. 14 (10B): 2121–7. doi:. A digital object identifier ( DOI) is a permanent identifier given to an Electronic document. PMID 15489334.
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